Theme of Nature and Landscape in English Romanticism and American Transcendentalism in Poetry

In this paper the Theme of Natural Landscape in English Romanticism and American Transcentralism in Poetry, the title brings out the importance of Nature by a Various poets. It deals about the view of Eminent poets like Emily Dickinson, William Wordsworth, William Cullent Bryant their views about the description of the Landscape in their poems. It brings out the Importance of a theory of Romanticism and Transcentralism, Problem of Ecology, social responsibility of the Individual to protect their Environment and the Final view of this paper

A PROSPECTIVE OBSERVATIONAL STUDY ON DISTRIBUTION PATTERN OF ADVERSE EFFECTS OF BRONCHODILATORS AMONG BRONCHIAL ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL IN A RURAL AREA OF KANCHEEPURAM DISTRICT

Objectives: The objectives of the study were (i) to study the distribution pattern of adverse effects of bronchodilators at initiation or during the course of therapy, (ii) to make a causality assessment of adverse effect identified using the WHO adverse drug reaction (ADR) probability scale, and (iii) to identify next drug tolerated better by him/her. Materials and Methods: This is an observational study that lasted for duration of 2 months. Inclusion Criteria: All patients reporting ADR after initiation of bronchodilator or during the course of bronchodilator therapy for bronchial asthma/ chronic obstructive pulmonary disease within the study period were included in the study. The suspected adverse effect was noted and documented. Causality assessment based on the WHO scale was employed. Results: During the study period, ten patients reported to have ADR for bronchodilators were identified and the WHO Causality Scale for ADR was applied and the better drug tolerated by the patient was noted. Conclusion: Inhalational forms of longer acting beta-2 agonists were better compliable to the patients with no observable adverse effects

SEIZURES WITH ANTI-SEIZURE DRUG

This case study is to report and explore the etiology of a case of refractory seizures due to overdosage of phenytoin tablets. A case report from the Department of Neurology generated through voluntary adverse drug reaction (ADR)reporting stated phenytoin overdosage leading to refractory status epilepticus which did not respond to any of the antiepileptic drugs. A 33-year-old female patient with the history of consumption 15 tablets of phenytoin and a metal ring as part of a suicidal bid a month ago, presented with unconsciousness, persistent seizures, and gangrene of fingers. Magnetic resonance imaging showed generalized atrophic changes of the cerebrum and cerebellum. Electroencephalogram suggested multifocal onset status epilepticus. The patient did not respond to standard emergency treatment of status epilepticus with known antiepileptic drugs and was treated with thiopentone infusion under mechanical ventilation, which controlled her seizures as long as she was maintained under the infusion. Causality analysis using the World Health Organization scale categorizes this ADR as possibleâ€, as the patient is a known case of seizure disorder with additional cerebral changes. Hence, the disease could have had an influence over the toxic reaction. To conclude, seizures are a rare complication of phenytoin. Seizures can be prevented by evaluating therapeutic plasma concentration of phenytoin. In this case, the patient was on chronic treatment, and due to intentional toxicity, she progressed to a refractory state of seizures. This could have occurred because of the unique kinetic profile of phenytoin, small therapeutic index, genetic variation in drug metabolizing enzymes, and saturated sodium channels

PHARMACOGNOSTIC, PHYSICOCHEMICAL, AND PHYTOCHEMICAL STUDIES ON STEM BARK OF ZANTHOXYLUM ARMATUM DC.

Objectives: To analyze the microscopic, macroscopic, physicochemical, and phytochemical standards of the Zanthoxylum armatum DC. (stem bark). Methods: Pharamacognostic studies, namely macroscopic, microscopic, and powder microscopic analysis of stem bark were carried out. Physicochemical standards - ash content including total ash content, water soluble, and acid insoluble ash values, moisture content by loss on drying, solubility and extractive values of Z. armatum DC. were determined. Preliminary phytochemical screening, fluorescence analysis and quantification of alkaloids, flavonoids, phenol, tannins, saponins, and terpenoids were also studied. Results: The macroscopic studies of stem bark showed the stem and its branches, armed with long, sharp prickles with variable size. The transverse section of bark showed the phellogen, phelloderm, cortex, phloem, and medullary rays that are characteristics to Z. armatum DC. The results of physicochemical standards give the identity and purity of the selected sample. Phytochemical studies revealed the presence of alkaloids, flavonoids, phenols, tannins, saponins, and terpenoids. Conclusion: The present findings provide the pharmacognostic, physicochemical, and phytochemical information about the stem bark of Z. armatum and this might be useful by providing additional support with regard to its identification and standardization parameters

Screening of finger millet genotypes for sodicity tolerance using the Na+/K+ ratio as a major physiological trait

Sodicity affects a larger area than salinity, but research on the sodicity tolerance mechanism is limited. The study was carried out to screen 120 finger millet genotypes under sodic soil conditions and identify sodicity-tolerant genotypes. The experimental field soil conditions were sandy clay loam with pH 8.9, electrical conductivity (EC) 0.94 dSm-1 and exchangeable sodium percentage (ESP) 21.5, which was naturally sodic. Grain yield per plant and Na+/K+ ratio were recorded for each genotype to screen sodicity tolerance among the genotypes. A significantly higher grain yield per plant than that of the sodicity-tolerant check variety TRY 1 (23.10 g) was observed in 30 finger millet genotypes. The analysis of sodium and potassium revealed that these 30 finger millet genotypes also recorded a significantly lower Na+/K+ ratio, which is comparatively lower than that of the sodicity-tolerant check variety TRY 1 (0.23 Na+/K+ ratio). The genotypes (FIN 3045, FIN 2875, FIN 3077, FIN 3015, FIN 3063, FIN 2861, FIN 3028, FIN 2867, FIN 2854, FIN 2860, FIN 2872, FIN 2896, FIN 4268, FIN 3034, FIN 3928, FIN 3104, FIN 3965, FIN 3091, FIN 2960, FIN 3994, FIN 4198, FIN 3174, FIN 3078, FIN 4288, FIN 4202, FIN 4238, FIN 3089, FIN 4205, FIN 3966 and FIN 3182) that recorded higher grain yield per plant and lower Na+/K+ ratio can be considered sodicity tolerant. These genotypes with a high grain yield per plant and a low Na+/K+ ratio could be utilized in stress breeding programs to develop sodicity-tolerant finger millet varieties

Improving privacy and security of data using Secured Distributable Cloud Storage (SDCS)

Cloud Computing is a recent BUZZWORD in the IT world. Behind this fancy poetic phrase there lies a true picture of the future of computing for both in technical perspective and social perspective. There are three issues that we are going to consider in cloud computing. First is Security Issue, security loss says about how the data is being used by the server providers. They try to business your data that you have stored in their servers. To overcome this Issue, we use the concept of Distributed Storage System. Second one is Data Loss, the problem of the ever increasing threat of Malware and Ransomware to cloud storage has led to the option of storing a copy the user data on Proxy Server. Third is, issues on Hacking, it is illegal access of data. Hackers are the crackers who hack the data during transmission of data either for social good purpose or for personal purpose. Cryptographic Data splitting with dynamic approach is used for securing information

IN VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY OF ULVA LACTUCA L.USING MOLT-3 CELL LINE

Objective: The aim of the present investigation was to determine the in vitro antioxidant and anticancer activity of the ethanol extract of Ulva lactuca L. Methods: The present study was to investigate the antioxidant and anticancer activity of U. lactuca L. The extract of U. lactuca L. was extracted by ethanol and subject to analysis. An in vitro antioxidant activity of the ethanol extract of U. lactuca L. was performed by 1, 1-diphenyl-2-picrylhydrazyl free radical scavenging assay. Simultaneously anticancer activity was also performed using blood cancer (MOLT-3) cell line, and the species showed a strong selective cell proliferation inhibition of the cancer cell line. Results: The scavenging activity was measured and determined to be 78.5%. This might be due to high polyphenolic compounds and flavonoid contents of the extract, which showed maximum growth inhibition of 74.4%. Conclusion: Thus, the study concludes that the constituents of seaweeds can act as potent in treating various diseases and can be used as an alternative for therapeutic treatment

Clinical and lab studies on suspected cases of microbial keratitis: A hospital based study

INTRODUCTION: Like most socio-economic problems of this subcontinent the problem of blindness in India is of colossal magnitude. The number of totally blind in India are about 14/1000 population out of which corneal blindness accounts for about 9-12 %.Low standards of health, poverty and ignorance are among the most fundamental causes of this high incidence of blindness in India. Corneal blindness is a disaster because majority of corneally blind are blind from a young age and therefore cannot be educated and are nonearning members of the family. If the corneally blind are not treated and cured, they remain a liability to the family and community for the rest of their lives. Corneal infections are sight threatening conditions, which if not treated as an emergency may lead to total blindness. The organisms most commonly isolated vary from one geographic region to the other depending upon the climate, soil and pattern of patient referrals. The present study is undertaken to know the aetiology, incidence and pattern of corneal infections amongst patients treated at Stanley medical college hospital Chennai. AIM OF THE STUDY: (i) To determine the frequency of occurance of microbial keratitis in patients presenting at Stanley Medical College, Ophthalmology Department. (ii) To find the correlation between the aetiological agents of Microbial Keratitis and the age, sex and occupation of the patients and trauma and other pre disposing factors for microbial keratitis. (iii) To evaluate the presence of certain clinical features as aids to diagnosis of microbial keratitis. (iv) To evaluate the use of direct microscopic staining techniques and culture media as aid to the diagnosis of microbial keratitis. (v) To isolate the common causative organisms of microbial keratitis among patients presenting to our department. MATERIALS & METHODS: The study was performed on 150 patients presenting with suspected microbial keratitis at Ophthalmology Department in Stanley Medical College Hospital. SUMMARY: 50 healthy controls were investigated for normal conjunctival bacterial and fungal flora. Bacterial growth was found in 56% of healthy conjunctival sacs. No fungal growth was found in normal conjunctival sac. Coagulase negative staphylococci was the commonest organism isolated being present in 56% of cases. CONCLUSION: Corneal ulcer is an important ocular emergency, in which if treatment is started with adequate and appropriate antibiotics can prevent impairment of vision. Early diagnosis and knowledge of agents involved are of utmost importance to start appropriate therapy. Each case should be treated after investigating into exact cause of the disease

NAPROXEN INDUCED ERYTHEMA MULTIFORME-A RARE CASE REPORT

Erythema multiforme (EM) is a hypersensitivity reaction characterized by varying degrees of blisters and ulcerations. We report a case of 4 y old girl child born for Non-custodial parents who has a history of seizures and a known case of carbamazepine-induced SLE (Systemic Lupus Erythematosus) when treated with anti-inflammatory drugs developed EM. The offending drug was identified and withdrawn. Steroid was given as a part of symptomatic treatment. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed groups of drugs for a variety of indications. The patient gradually improved and got discharged

RP-HPLC Method Development and Validation, Stability Studies of Sildenafil Citrate in Soft Gelatin Capsule Dosage Form

AIM AND OBJECTIVE :The drug analysis plays an important role in all aspects regarding the drug right the development to the therapeutic use of the drug. Industries manufacturing pharmaceutical must ensure that the raw material used and the final product obtained meets the required specification to fulfill this purpose they rely upon quantitative chemical analysis. The Literature survey indicates that a very few methods were developed for the estimation of sildenafil citrate by RP-HPLC and UV in bulk and tablet dosage form. So an attempt was made to develop a new RP-HPLC method for sildenafil citrate in soft gelatin capsules which is more reliable, economical and flexible. The objective of the present work is to develop a new method of estimation for sildenafil citrate in soft gelatin capsules by RP-HPLC method. So an attempt was made to develop and validate a simple, precise, accurate, linear and rapid RP-HPLC method as per ICH guidelines for the estimation of sildenafil citrate and to apply the developed method to determine the validation of compounds. SUMMARY AND CONCLUSION: A RP-HPLC method is developed and validated as per ICH guidelines for sildenafil citrate soft gelatin capsule dosage form. This validation of statistical parameter is found that the analytical procedure for Sildenafil Citrate Soft gelatin Capsules 50 mg meets system suitability requirements and acceptance criteria for Specificity, Linearity, Precision, Accuracy, Robustness, Ruggedness parameters and Solution stability. Considering all the fact the following parameter were finally fixed for this method Equipment : High performance liquid chromatography(agilent 1260) Mobile phase : Ammonium acetate :Acetonitrile Column : waters reliant C18, 15 cm x 4.6 mm, 5 μm Flow Rate : 1.0 mL/minute Pump mode : Isocratic Detector wavelength : 240 nm Injection volume : 20 μL Column Temperature : 25.0°C The proposed method was found to be rapid, accurate, precise, specific, robust, rugged and economical. The mobile phase is simple to prepare and economical. The sample recoveries in all formulations were in good agreement with their respective label claims and they suggested non-interference of formulation excipients in the estimation. This method is also having an advantage than reported method that the retention time of the drugs is below 5 mins and the drugs can be assayed with the short time. Thus the method is not time consuming and can be used in laboratories for the routine analysis of combination drugs