Cadmium Contamination in Farmland Soil and Water Near Zinc Mining Site

This study was a cross-sectional study conducted in Phatadpadaeng Subdistrict, Mae Sod District, Tak Province, Thailand. This study aimed to determine cadmium concentration in farmland soil and water as well as at the residence of farmers and households. As many as 48 samples of farmers' residence soil and water, twelve samples of households and six samples of farmland soil and eight samples of farmland water were investigated for cadmium concentration using Graphite Furnace Atomic Absorption Spectrophotometer. The Mann-Whitney U test was used for the analysis of the difference of cadmium concentration between farmland soil and residence soil, farmland water and residence water. The results showed no statistically difference among all matrixes, however, farmland soil and farmland water showed highest concentration compared to those of resident farmers and households. The cadmium concentrations in all samples were far below the limit values. This study clearly showed that working conditions of farmers demonstrated higher level of cadmium compared to the living conditions. The cause of this contamination might be from the activities of the surroundings industry. Therefore, it would be recommended that farmers should consider for cadmium exposure while working in farm

Bioactivity of miltefosine against aquatic stages of Schistosoma mansoni, Schistosoma haematobium and their snail hosts, supported by scanning electron microscopy

<p>Abstract</p> <p>Background</p> <p>Miltefosine, which is the first oral drug licensed for the treatment of leishmaniasis, was recently reported to be a promising lead compound for the synthesis of novel antischistosomal derivatives with potent activity <it>in vivo </it>against different developmental stages of <it>Schistosoma mansoni</it>. In this paper an <it>in vitro </it>study was carried out to investigate whether it has a biocidal activity against the aquatic stages of <it>Schistosoma mansoni </it>and its snail intermediate host, <it>Biomphalaria alexandrina </it>, thus being also a molluscicide. Additionally, to see whether miltefosine can have a broad spectrum antischistosomal activity, a similar <it>in vitro </it>study was carried out on the adult stage of <it>Schistosoma haematobium</it>, the second major human species, its larval stages and snail intermediate host, <it>Bulinus truncutes</it>. This was checked by scanning electron microscopy.</p> <p>Results</p> <p>Miltefosine proved to have <it>in vitro </it>ovicidal, schistolarvicidal and lethal activity on adult worms of both <it>Schistosoma </it>species and has considerable molluscicidal activity on their snail hosts. Scanning electron microscopy revealed several morphological changes on the different stages of the parasite and on the soft body of the snail, which further strengthens the current evidence of miltefosine's activity. This is the first report of mollusicidal activity of miltefosine and its <it>in vitro </it>schistosomicidal activity against <it>S.haematobium</it>.</p> <p>Conclusions</p> <p>This study highlights miltefosine not only as a potential promising lead compound for the synthesis of novel broad spectrum schistosomicidal derivatives, but also for molluscicidals.</p