A comparative analysis of 21 literature search engines

With increasing number of bibliographic software, scientists and health professionals either make a subjective choice of tool(s) that could suit their needs or face a challenge of analyzing multiple features of a plethora of search programs. There is an urgent need for a thorough comparative analysis of the available bio-literature scanning tools, from the user’s perspective. We report results of the first time semi-quantitative comparison of 21 programs, which can search published (partial or full text) documents in life science areas. The observations can assist life science researchers and medical professionals to make an informed selection among the programs, depending on their search objectives. 
Some of the important findings are: 
1. Most of the hits obtained from Scopus, ReleMed, EBImed, CiteXplore, and HighWire Press were usually relevant (i.e. these tools show a better precision than other tools). 
2. But a very high number of relevant citations were retrieved by HighWire Press, Google Scholar, CiteXplore and Pubmed Central (they had better recall). 
3. HWP and CiteXplore seemed to have a good balance of precision and recall efficiencies. 
4. PubMed Central, PubMed and Scopus provided the most useful query systems. 
5. GoPubMed, BioAsk, EBIMed, ClusterMed could be more useful among the tools that can automatically process the retrieved citations for further scanning of bio-entities such as proteins, diseases, tissues, molecular interactions, etc. 
The authors suggest the use of PubMed, Scopus, Google Scholar and HighWire Press - for better coverage, and GoPubMed - to view the hits categorized based on the MeSH and gene ontology terms. The article is relavant to all life science subjects.
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Ranking of Search Engines in View of Information Explosion

Deals with collection of number of records published on Web, on 23 Main Classes of Colon Classification from 1st January to 31st March 2014 on daily basis, using 5 Search Engines – Google, Lycos, Microsoft, Rediff and Yahoo. Ranking of 5 Search Engines, 23 Main Classes, and the months of January, February and March 2014 has been carried-out, based on number of records they retrieved during the period of study. DOI: 10.17762/ijritcc2321-8169.150518

Acromegaly incidentally diagnosed at term in a pregnant woman presenting with ventricular premature complexes

Pituitary adenomas lead to increased growth hormone production and acromegaly. Pregnancy in acromegaly is rare as spontaneous conception is affected. We presented a case of 31 year old lady conceived by ovulation induction and presented at term gestation with ventricular premature complexes and was subsequently diagnosed with pituitary micro adenoma causing acromegaly. There has been no reported case of pregnancy with acromegaly presenting with premature ventricular complexes. Moreover, diagnosis of acromegaly in pregnancy is difficult and limited literature is available on its effects as well as management

Acute toxicity study of seeds of Achyranthes aspera, bark of Berberis aristata and roots of Coleus forskohlii in Wistar rats

Background: Achyranthes aspera is a species of plant in the family Amaranthaceae. Berberis aristata is a shrub belonging to the family Berberidaceae and the genus Berberis. Plectranthus barbatus is a tropical perennial plant related to the typical coleus species. It produces forskolin, an extract useful for pharmaceutical preparations and research in cell biology. It is belonging to Lamiaceae. The present study has been undertaken to study the toxic effects of hydro alcoholic extracts of A. aspera, B. aristata, C. forskohlii in albino Wistar rats and to establish the hazardous safety category of hydro alcoholic extracts of these plants as per organization for economic cooperation and development (OECD-423) guidelines and GHS classification system respectively.Methods: In acute toxicity study, the hydro-alcoholic extracts of all the above three plants were given orally at the dose of 2000 mg/kg b. w. to three rats in each group respectively in step I. Then, all the animals were observed for initial 4 hours and followed by fourteen days for their clinical signs and mortality in step II.Results: In step I, all the animals were normal and there was no mortality after 48 hours. In step II with the same dose, all the animals showed no adverse effects and no mortality when followed up to 14 days observation period.Conclusions: The result indicates that the hydro alcoholic extracts of A. aspera, B. aristata, C. forskohlii plants can be utilized safely for therapeutic use in pharmaceutical formulations and it falls under category ‘5’ or ‘unclassified’ of GHS system

Review Paper: Procuring Frequent and Sequential Items to Improve Product Sales in E-Commerce Sites

Increase in e-commerce industry has lead to availability of large amounts of data. Data is an important for everyone. There are hundreds of websites being deployed and each site offers millions of products. This means that there is a substantial amount of information being provided resulting in information overload and in turn results in reduced customer satisfaction and interest. Presenting frequent and sequential patterns in e-commerce sites results in increase of sales of products without delay. Different association rule mining techniques can be used for generating frequent and sequential patterns

Empowering indigenous communities in India through the use of design thinking methods

The project explored how user-led design research methods such as design thinking can be used to engage with, and empower indigenous communities in rural India, with a focus on how to improve their health and well-being. The project was a collaboration with researchers from Amrita Vishwa Vidyapeetham in India; villagers from indigenous tribal communities in the Kerala State of India; medical doctors and healthcare workers who work in these rural communities; and experts in eHealth solutions. The design thinking methods used in the project are based on many of the key principles of indigenous research methods, but also put a strong emphasis on how to generate impact by considering solutions that are desirable, feasible and viable. The project included ethnographic field work in three tribal villages in the Wayanad district of Kerala; participatory workshops to help discover and develop new ideas to meet the health needs of the indigenous tribal communities; and reflections by tribal villagers and healthcare workers on the benefits of the project, as well as limitations and on-going challenges. This paper documents the approach taken in the project and the lessons learnt - in particular, how design thinking methods and techniques can be effectively used to engage with indigenous communities in a respectful manner, to ensure equitable partnership, and to enable the mobilization of knowledge to help improve the health and well-being of indigenous communities in India

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS QUANTIFICATION OF SORAFENIB AND REGORAFENIB DRUG SUBTANCES BY USING RP-UPLC

Objective: The aim of the research work is to develop and validate a novel, sensitive, specific, rapid, accurate, precise and stability indicating gradient reverse phase ultra-performance liquid chromatography (RP-UPLC) method for the quantitative determination of sorafenib and regorafenib drug substances. Methods: Liquid chromatographic method used for the analysis of the anti-cancer drug substances like sorafenib and regorafenib and method was developed and validated by using efficient chromatographic separation method and was achieved with the use of acquity UPLC system was used consisting of quaternary pump, photodiode array detector an auto injector and on line degasser. Results: The separation was achieved using acquity UPLC BEH C18, 1.7 µm.2.1×50 mm analytical column at 30 °C employing a gradient elution. Empower software was used for data acquisition. During method validation all the parameters were evaluated as per ICH guidelines, which remained well within acceptable limits. Degradation of the drug substances was found to be stable to acidic, aqueous, basic hydrolysis, thermal hydrolysis and photolytic stress condition and the tests solution of the drug substance was found to be stable up to 24 h. Conclusion: The results of linearity, precision accuracy and specificity were proved to be within the limits. This method can be employed in routine analysis for simultaneous estimation of sorafenib andregorafenib drug substances in quality formulations and dissolution studies

Dissecting Malicious Word, PDF Documents

Internet and computers are now a part of our daily routine life. With the development of network and information technology, E-mail has became increasingly popular and the society’s indispensable need. However, virus spreading via the E-mail is also increasing at an enormous rate. The E-mail attachment such as PDF Document, Microsoft Word Document, EXE program can spread viruses from one computer to another computer. This paper describes and analyses the various forms of the E-mail viruses via the Microsoft Word Documents and the PDF Documents. We describe the methodology to detect such E-mail viruses using tools such as OfficeMalscanner for Word Documents and PDF stream Dumper for PDF Documents