8,722 research outputs found

    At its Heart, Homeostasis Is About T Cells∗

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    Learning from information crises: Exploring aggregated trustworthiness in big data production

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    In a crisis situation when traditional venues for information dissemination aren't reliable and information is needed immediately "aggregated trustworthiness", data verification through network evaluation and social validation, becomes an important alternative. However, the risk with evaluating credibility through trust and network reputation is that the perspective can get biased. In these socially distributed information systems there is therefore of particularly high importance to understand how data is socially produced by whom. The purpose with the research project presented in this position paper is to explore how patters of bias in information production online can become more transparent by including tools that analyze and visualize aggregated trustworthiness. the research project consists of two interconnected parts. We will first look into a recent crisis situation, the case Red Hook after Hurricane Sandy, to see how the dissemination of information took place in the recovery work, focusing on questions of credibility and trust. Thereafter, this case study will inform the design of two collaborative tools where we investigate how social validation processes can be made more transparent

    Microscopic theory of the quantum Hall hierarchy

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    We solve the quantum Hall problem exactly in a limit and show that the ground states can be organized in a fractal pattern consistent with the Haldane-Halperin hierarchy, and with the global phase diagram. We present wave functions for a large family of states, including those of Laughlin and Jain and also for states recently observed by Pan {\it et. al.}, and show that they coincide with the exact ones in the solvable limit. We submit that they establish an adiabatic continuation of our exact results to the experimentally accessible regime, thus providing a unified approach to the hierarchy states.Comment: 4 pages, 2 figures. Publishe

    Quasihole condensates in quantum Hall liquids

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    We develop a formalism to describe quasihole condensates in quantum Hall liquids and thereby extend the conformal field theory approach to the full hierarchy of spin-polarized Abelian states, and to several classes of non-Abelian hierarchical states. Most previously proposed spin-polarized quantum Hall wave functions appear as special cases. In this paper we explain the physical motivations for the approach, and exemplify it by explicitly constructing the level-two quasihole condensate state at filling fraction 2/3, and the two level-three states at 5/13 and 5/7 which are built from combinations of quasielectron and quasihole condensates.Comment: 16 page

    Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies

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    Atherosclerosis constitutes the underlying disease to the clinical manifestations of myocardial infarction, stroke, and gangrene. Despite the success of statins, prevention of clinical events of atherosclerosis remains a major challenge in current-day cardiology. Research into the inflammatory nature of atherosclerosis has led to improved mechanistic understanding of its pathogenesis and to the identification of novel therapeutic targets discussed in this review. Recent genetic and epidemiological data document shared pathologies of chronic inflammatory diseases and atherosclerosis. Anti-inflammatory treatment regimens used in these diseases, including tumor necrosis factor-α blockade, IL-1 receptor antagonism, and leukotriene blockade may be beneficial also in patients with coronary artery disease. Enhancing inherent atheroprotective immunity by expansion of regulatory T cells may emerge as a future therapeutic strategy. Immunization strategies directed against atherosclerosis-related antigens such as epitopes within the low-density lipoprotein particle have been extensively studied in animal models and may enter the clinical stage. Success of these novel therapies will be critically dependent on the adequate identification of patients and choice of appropriate clinical endpoint

    Kinetic evidence for the function of Z in isolated photosystem II reaction centers

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    Abstract(D1,D2) Photosystem II reaction centers were studied by flash absorption spectroscopy with microsecond resolution. Without addition, absorption transients in the 660–850 nm region are due to a triplet state, probably of P-680, with a decay half-time of 700 ÎŒs (no oxygen) or 40 ÎŒs (under air). With the addition of DBMIB, presumably acting as electron acceptor, new kinetic and spectral features appear, which are attributed to P-680. A 5 ÎŒs phase of decay is present, which is pH-dependent and is attributed to donation from Z to P-680+

    Solitons and Quasielectrons in the Quantum Hall Matrix Model

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    We show how to incorporate fractionally charged quasielectrons in the finite quantum Hall matrix model.The quasielectrons emerge as combinations of BPS solitons and quasiholes in a finite matrix version of the noncommutative ϕ4\phi^4 theory coupled to a noncommutative Chern-Simons gauge field. We also discuss how to properly define the charge density in the classical matrix model, and calculate density profiles for droplets, quasiholes and quasielectrons.Comment: 15 pages, 9 figure

    Quantum Hall quasielectron operators in conformal field theory

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    In the conformal field theory (CFT) approach to the quantum Hall effect, the multi-electron wave functions are expressed as correlation functions in certain rational CFTs. While this approach has led to a well-understood description of the fractionally charged quasihole excitations, the quasielectrons have turned out to be much harder to handle. In particular, forming quasielectron states requires non-local operators, in sharp contrast to quasiholes that can be created by local chiral vertex operators. In both cases, the operators are strongly constrained by general requirements of symmetry, braiding and fusion. Here we construct a quasielectron operator satisfying these demands and show that it reproduces known good quasiparticle wave functions, as well as predicts new ones. In particular we propose explicit wave functions for quasielectron excitations of the Moore-Read Pfaffian state. Further, this operator allows us to explicitly express the composite fermion wave functions in the positive Jain series in hierarchical form, thus settling a longtime controversy. We also critically discuss the status of the fractional statistics of quasiparticles in the Abelian hierarchical quantum Hall states, and argue that our construction of localized quasielectron states sheds new light on their statistics. At the technical level we introduce a generalized normal ordering, that allows us to "fuse" an electron operator with the inverse of an hole operator, and also an alternative approach to the background charge needed to neutralize CFT correlators. As a result we get a fully holomorphic CFT representation of a large set of quantum Hall wave functions.Comment: minor changes, publishe

    Reasoning with comparative moral judgements: an argument for Moral Bayesianism

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    The paper discusses the notion of reasoning with comparative moral judgements (i.e judgements of the form “act a is morally superior to act b”) from the point of view of several meta-ethical positions. Using a simple formal result, it is argued that only a version of moral cognitivism that is committed to the claim that moral beliefs come in degrees can give a normatively plausible account of such reasoning. Some implications of accepting such a version of moral cognitivism are discussed
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