Prévalence des accommodements pour l’examen d’aptitude du Conseil médical du Canada, partie I, 2013-2021

Introduction: Previous articles have highlighted the laborious process of acquiring disability accommodations in medical education. We endeavoured to characterize the trends of test accommodations on the MCCQE Part I. Methods: Data was obtained from the Medical Council of Canada on the number of applicants who attained test accommodations on the MCCQE Part I between 2013 and 2021. The number of test takers for the same period was obtained from the Medical Council of Canada’s Annual Technical Reports; this data was not publicly available for 2013, 2014, or 2021. Prevalence rates and graphs were produced. Results: The number of test takers who attained test accommodations ranged from 35 to 126 between 2013 and 2021. The percentage of test takers who attained test accommodations ranged from 0.89% to 2.01% between 2015 and 2020. Per correspondence with the Medical Council of Canada, no applicant who provided all required documentation was denied test accommodations during this period. Discussion: The number and rate of test takers attaining test accommodations on the MCCQE Part I have increased substantially during this period. It is unclear whether this increase is due to greater rates of students with disabilities, or a reduction in stigma around using test accommodations.Introduction : Des articles publiés antérieurement ont mis en évidence le processus laborieux d’obtention d’accommodements pour les personnes handicapées dans le cadre de la formation en médecine. Nous explorons les tendances en matière d’accommodements pour l’examen d’aptitude du Conseil médical du Canada (EACMC), partie I. Méthodes : Le Conseil médical du Canada nous a communiqué le nombre de candidats qui ont obtenu des accommodements pour l’EACMC, partie I, entre 2013 et 2021. Le nombre de candidats ayant passé l’examen au cours de la même période a été obtenu en consultant les rapports techniques annuels du Conseil médical du Canada; les données pour 2013, 2014 et 2021 n’étaient pas accessibles au public. Nous présentons des taux de prévalence et des graphiques. Résultats : Le nombre de candidats ayant bénéficié d’accommodements a varié de 35 à 126 entre 2013 et 2021. Le pourcentage de ces candidats a varié de 0,89 % à 2,01 % entre 2015 et 2020. Selon la correspondance du Conseil médical du Canada, aucun candidat ayant fourni les documents requis ne s’est vu refuser l’accommodement d’examen au cours de cette période. Discussion : Le nombre et le taux de candidats bénéficiant d’accommodements pour l’EACMC, partie I, ont considérablement augmenté au cours de la période visée. On ne sait pas si cette hausse est due à une augmentation du nombre d’étudiants handicapés ou à une réduction de la stigmatisation liée au recours aux accommodements d’examen

PEGylation of nanoparticles improves their cytoplasmic transport

The efficacy of nucleus-targeted drug- or gene-carrying nanoparticles may be limited by slow transport through the molecularly crowded cytoplasm following endosome escape. Cytoskeletal elements and cellular organelles may pose steric and/or adhesive obstacles to the efficient intracellular transport of nanoparticles. To potentially reduce adhesive interactions of colloids with intracellular components, the surface of model nanoparticles was coated with polyethylene glycol (PEG). Subsequently, multiple-particle tracking (MPT) was used to quantify the cytoplasmic transport rates of particles microinjected into the cytoplasm of live cells. PEGylation increased average nanoparticle diffusivities by 100% compared to unPEGylated particles (time scale of 10 s) in live cells. Faster particle transport correlated with a marked decrease in the number of particles that underwent hindered transport, from 79.2% (unmodified) to 48.8% (PEGylated). This result adds to an impressive list of positive benefits associated with PEGylation of drug and gene delivery vectors

A Wide Symbiotic Channel to Type Ia Supernovae

As a promising channel to Type Ia supernovae (SNe Ia), we have proposed a symbiotic binary system consisting of a white dwarf (WD) and a low mass red-giant (RG), where strong winds from the accreting WD play a key role to increase the WD mass to the Chandrasekhar mass limit. Here we propose two new evolutionary processes which make the symbiotic channel to SNe Ia much wider. (1) We first show that the WD + RG close binary can form from a wide binary even with such a large initial separation as $a_i \lesssim 40000 R_\odot$. Such a binary consists of an AGB star and a low mass main-sequence (MS) star, where the AGB star is undergoing superwind before becoming a WD. If the superwind at the end of AGB evolution is as fast as or slower than the orbital velocity, the wind outflowing from the system takes away the orbital angular momentum effectively. As a result the wide binary shrinks greatly to become a close binary. Therefore, the WD + RG binary can form from much wider binaries than our earlier estimate. (2) When the RG fills its inner critical Roche lobe, the WD undergoes rapid mass accretion and blows a strong optically thick wind. Our earlier analysis has shown that the mass transfer is stabilized by this wind only when the mass ratio of RG/WD is smaller than 1.15. Our new finding is that the WD wind can strip mass from the RG envelope, which could be efficient enough to stabilize the mass transfer even if the RG/WD mass ratio exceeds 1.15. With the above two new effects (1) and (2), the symbiotic channel can account for the inferred rate of SNe Ia in our Galaxy.Comment: 29 pages including 14 firgures, to be published in ApJ, 521, No.

Substructure in the Andromeda Galaxy Globular Cluster System

In the most prominent current scenario of galaxy formation, galaxies form hierarchically through the merger of smaller systems. Such mergers could leave behind dynamical signatures which may linger long after the event. In particular, the globular cluster system (GCS) of a merging satellite galaxy may remain as a distinct sub-population within the GCS of a massive galaxy. Using the latest available globular cluster velocities and metallicities, we present the results of a search for grouping in the GCS of our nearest large spiral galaxy neighbor, M31. A modified friends-of-friends algorithm is used to identify a number of possible merger remnants in projected position, radial velocity and [Fe/H] parameter space. Numerical simulations are used to check that such merger remnants are indeed plausible over the timescales of interest. The identification of stellar streams associated with these groups is required in order to confirm that they represent merger remnants.Comment: 19 pages, 3 figures, accepted for publication in the Ap

Mucoadhesive Nanoparticles May Disrupt the Protective Human Mucus Barrier by Altering Its Microstructure

Mucus secretions typically protect exposed surfaces of the eyes and respiratory, gastrointestinal and female reproductive tracts from foreign entities, including pathogens and environmental ultrafine particles. We hypothesized that excess exposure to some foreign particles, however, may cause disruption of the mucus barrier. Many synthetic nanoparticles are likely to be mucoadhesive due to hydrophobic, electrostatic or hydrogen bonding interactions. We therefore sought to determine whether mucoadhesive particles (MAP) could alter the mucus microstructure, thereby allowing other foreign particles to more easily penetrate mucus. We engineered muco-inert probe particles 1 µm in diameter, whose diffusion in mucus is limited only by steric obstruction from the mucus mesh, and used them to measure possible MAP-induced changes to the microstructure of fresh human cervicovaginal mucus. We found that a 0.24% w/v concentration of 200 nm MAP in mucus induced a ∼10-fold increase in the average effective diffusivity of the probe particles, and a 2- to 3-fold increase in the fraction capable of penetrating physiologically thick mucus layers. The same concentration of muco-inert particles, and a low concentration (0.0006% w/v) of MAP, had no detectable effect on probe particle penetration rates. Using an obstruction-scaling model, we determined that the higher MAP dose increased the average mesh spacing (“pore” size) of mucus from 380 nm to 470 nm. The bulk viscoelasticity of mucus was unaffected by MAP exposure, suggesting MAP may not directly impair mucus clearance or its function as a lubricant, both of which depend critically on the bulk rheological properties of mucus. Our findings suggest mucoadhesive nanoparticles can substantially alter the microstructure of mucus, highlighting the potential of mucoadhesive environmental or engineered nanoparticles to disrupt mucus barriers and cause greater exposure to foreign particles, including pathogens and other potentially toxic nanomaterials

Galantamine Attenuates Type 1 Diabetes and Inhibits Anti-Insulin Antibodies in Non-Obese Diabetic Mice

Type 1 diabetes in mice is characterized by autoimmune destruction of insulin-producing pancreatic beta cells. Disease pathogenesis involves invasion of pancreatic islets by immune cells, including macrophages and T cells, and production of antibodies to self-antigens, including insulin. Activation of the inflammatory reflex, the neural circuit that inhibits inflammation, culminates on cholinergic receptor signals on immune cells to attenuate cytokine release and inhibit B cell antibody production. Here, we show that galantamine, a centrally acting acetylcholinesterase inhibitor and an activator of the inflammatory reflex, attenuates murine experimental type 1 diabetes. Administration of galantamine to animals immunized with keyhole limpet hemocyanin (KLH) significantly suppressed splenocyte release of immunoglobulin G (IgG), interleukin-4 and -6 (IL-4 and IL-6) during KLH-challenge ex vivo. Administration of galantamine beginning at one month of age in non-obese diabetic (NOD) mice significantly delayed the onset of hyperglycemia, attenuated immune cell infiltration in pancreatic islets and decreased anti-insulin antibodies in serum. These observations indicate that galantamine attenuates experimental type 1 diabetes in mice and suggest that activation of the inflammatory reflex should be further studied as a potential therapeutic approach

The Globular Cluster Systems of NGC 1400 and NGC 1407

The two brightest elliptical galaxies in the Eridanus A group, NGC 1400 and NGC 1407, have been observed in both the Washington T_1 and Kron-Cousins I filters to obtain photometry of their globular cluster systems (GCSs). This group of galaxies is of particular interest due to its exceptionally high M/L value, previously estimated at ~3000h, making this cluster highly dark-matter-dominated. NGC 1400's radial velocity (549 km/s) is extremely low compared to that of the central galaxy of Eridanus A (NGC 1407 with $v_\odot$ = 1766 km/s) and the other members of the system, suggesting that it is a foreground galaxy projected by chance onto the cluster. Using the shapes of the globular cluster luminosity functions, however, we derive distances of 17.6 +/- 3.1 Mpc to NGC 1407 and 25.4 +/- 7.0 Mpc to NGC 1400. These results support earlier conclusions that NGC 1400 is at the distance of Eridanus A and therefore has a large peculiar velocity. Specific frequencies are also derived for these galaxies, yielding values of S_N = 4.0 +/- 1.3 for NGC 1407 and S_N = 5.2 +/- 2.0 for NGC 1400. In this and other respects, these two galaxies have GCSs which are consistent with those observed in other galaxies.Comment: 14 pages (AASTeX), 3 postscript figures, submitted to the Astronomical Journa

A New Evolutionary Path to Type Ia Supernovae: Helium-Rich Super-Soft X-Ray Source Channel

We have found a new evolutionary path to Type Ia supernovae (SNe Ia) which has been overlooked in previous work. In this scenario, a carbon-oxygen white dwarf (C+O WD) is originated, not from an asymptotic giant branch star with a C+O core, but from a red-giant star with a helium core of $\sim 0.8-2.0 M_\odot$. The helium star, which is formed after the first common envelope evolution, evolves to form a C+O WD of $\sim 0.8-1.1 M_\odot$ with transferring a part of the helium envelope onto the secondary main-sequence star. This new evolutionary path, together with the optically thick wind from mass-accreting white dwarf, provides a much wider channel to SNe Ia than previous scenarios. A part of the progenitor systems are identified as the luminous supersoft X-ray sources or the recurrent novae like U Sco, which are characterized by the accretion of helium-rich matter. The white dwarf accretes hydrogen-rich, helium-enhanced matter from a lobe-filling, slightly evolved companion at a critical rate and blows excess matter in the wind. The white dwarf grows in mass to the Chandrasekhar mass limit and explodes as an SN Ia. A theoretical estimate indicates that this channel contributes a considerable part of the inferred rate of SNe Ia in our Galaxy, i.e., the rate is about ten times larger than the previous theoretical estimates for white dwarfs with slightly evolved companions.Comment: 19 pages including 12 figures, to be published in ApJ, 519, No.