510 research outputs found

    Multimorbidity and exit from paid employment:the effect of specific combinations of chronic health conditions

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    Background This study aimed to assess the association between multimorbidity and exit from paid employment, and which combinations of chronic health conditions (CHCs) have the strongest association with exit from paid employment. Methods Data from 111 208 workers aged 18-64 years from Lifelines were enriched with monthly employment data from Statistics Netherlands. Exit from paid employment during follow-up was defined as a change from paid employment to unemployment, disability benefits, economic inactivity or early retirement. CHCs included cardiovascular diseases (CVD), chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA), type 2 diabetes (T2DM) and depression. Cox-proportional hazards models were used to examine the impact of multimorbidity and combinations of CHCs on exit from paid employment. Results Multimorbidity increased the risk of exiting paid employment compared with workers without CHCs (hazard ratio (HR): 1.52; 95% confidence interval (CI): 1.35-1.71) or one CHC (HR: 1.14; 95% CI: 1.01-1.28). The risk for exit from paid employment increased among workers with COPD if they additionally had CVD (HR: 1.39; 95% CI: 1.03-1.88), depression (HR: 1.46; 95% CI: 1.10-1.93) or RA (HR: 1.44; 95% CI: 1.08-1.91), for workers with T2DM if they additionally had CVD (HR: 1.43; 95% CI: 1.07-1.91) or depression (HR: 2.09; 95% CI: 1.51-2.91) and for workers with depression who also had T2DM (HR: 1.68; 95% CI: 1.21-2.32). Conclusion This study showed that workers with multimorbidity, especially having a combination of COPD and depression or T2DM and depression, have a higher risk for early exit from paid employment and, therefore, may need tailored support at the workplace

    Fungos associados a clones de camucamuzeiro, muricizeiro e bacurizeiro no município de Tomé-Açu.

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    Diversos fatores são responsáveis pela redução da produtividade e morte de espécies frutíferas da Amazônia, dentre os quais, destaca-se a incidência de doenças, principalmente pelas condições edafoclimáticas da região. O objetivo do trabalho foi isolar e identificar fungos associados aos clones de camucamuzeiro, muricizeiro e bacurizeiro em experimentos localizados no Campo Experimental de Tomé-Açu-PA. Plantas apresentando sintomas de doenças foram fotografadas, coletadas, acondicionadas em sacos plásticos e transportadas para o Laboratório de Fitopatologia da Embrapa Amazônia Oriental. Foram realizados exames microscópicos, bem como o isolamento em meio de cultura para a classificação dos patógenos. Do material sintomático de plantas de bacurizeiro foram isolados os seguintes fungos: Pestalotiopsis sp., Lasiodiplodia sp., Curvularia sp., Phomopsis sp., Guignardia sp. e Nigrospora sp. De plantas sintomáticas de muricizeiro foram isolados, Pestalotiopsis sp., Lasiodiplodia sp., Calonectria sp., Rhizoctonia sp. e Phomopsis sp. e de plantas de camucamuzeiro isolou-se os fungos Lasiodiplodia sp., Phomopsis sp., Curvularia sp. e Guignardia sp. Todos os isolados fúngicos se encontram preservados em óleo mineral para posteriores testes de patogenicidade

    Green ear yield and grain yield of maize after harvest of the first ear as baby corn.

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    xEdição dos resumos do 45º Congresso Brasileiro de Olericultura; 15º Congresso Brasileiro de Floricultura e Plantas Ornamentais; 2º Congresso Brasileiro de Cultura de Tecidos de Plantas realizado em Fortaleza

    Fenologia e biometria de pinhão-manso no cerrado.

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    Estudos fenológicos de três acessos morfologicamente distintos de Jatropha curcas foram conduzidos no bioma Cerrado brasileiro. A taxa de crescimento da planta, florescimento, formação e desenvolvimento dos frutos foram medidos, a fim de se estabelecer práticas de manejo eficientes para o aumento de produtividade. Os acessos estudados foram: CNPAE-102 (tóxico, susceptível a oídio), CNPAE-169 (não-tóxico, susceptível a oídio) e CNPAE-259 (tóxico, resistente a oídio). Os materiais considerados não-tóxicos não possuem ésteres de forbol detectáveis nos grãos. No período de um ano (agosto de 2009 a julho de 2010) registraram-se, quinzenalmente, as variáveis agronômicas (altura de plantas, número de inflorescências, número de frutos verdes e maduros por planta) de cada acesso, correlacionando-as com as variáveis climáticas, por meio da análise de correlação de Pearson. O acesso CNPAE-102 apresentou a maior taxa de crescimento (0,76 cm dia-1), incremento 1,10 m na altura e altura final de 2,60 m; o CNPAE-169 apresentou menor incremento (0,63 cm dia-1), atingindo altura final de 1,85 m. Os acessos CNPAE-259 e CNPAE-102 foram os mais precoces, e o CNPAE-169 o mais tardio. A temperatura mínima foi a variável climática que determinou o maior número de inflorescências

    Green ear yield and grain yield of maize after harvest of the first ear as baby corn.

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    Baby corn (BC) consists of the corn ear harvested two or three days after silk emergence. BC is a profitable crop, making possible a diversification of production, aggregation of value and increased income. Removing the first female inflorescence induces corn to produce others, making possible to produce several BC ears or, alternatively, BC (by harvesting the first ear) and green ears or grain. The objective of this work was to evaluate green ear yield and grain yield, after harvesting the first ear as BC. Corn cultivar AG 1051 was submitted to the following treatments, in a random block design with ten replicates (52 plants per plot): BC harvesting; green ear harvesting (grain moisture content between 60 and 70%); mature ear harvesting; BC harvesting and harvesting of other ears as green or mature ears. Marketable green ears yield or grain yield produced without removing the first inflorescence were superior to the green ears yield or grain yield produced after removal of the first inflorescence harvested as baby corn. Harvesting only the first ear as baby corn, and then harvesting green ears or the mature ears, provided lower baby corn yields than that obtained by harvesting all ears as baby corn. Economically, the best net revenues would be obtained by exploring the crop for the production of green ears, green ears + baby corn, baby corn, baby corn + grain, and grain, in this order. O minimilho (MM) é a espiga do milho colhida dois a três dias após a emergência dos estilo-estigmas. O MM é rentável e propicia diversificação da produção, agregação de valor e ampliação de renda. A remoção da primeira inflorescência feminina induz o milho a produzir outras. Isso possibilita a produção de várias espigas de MM ou, alternativamente, MM (colhendo-se a primeira espiga) e espigas verdes ou grãos. O objetivo do trabalho foi avaliar os rendimentos de espigas verdes e de grãos, após a colheita da primeira espiga como MM. A cultivar AG 1051 foi submetida aos seguintes tratamentos, no delineamento de blocos ao acaso com dez repetições (52 plantas por parcela): colheita de MM; colheita das espigas verdes (grãos com teor de umidade de 60 a 70%); colheita das espigas maduras; colheita de MM e colheita das outras espigas como espigas verdes ou maduras. Os rendimentos de espigas verdes comercializáveis e de grãos, produzidos sem a remoção da primeira inflorescência, foram superiores aos rendimentos respectivos produzidos após a remoção da primeira inflorescência, colhida como minimilho. Colhendo-se somente a primeira espiga como minimilho e as demais espigas como espigas verdes ou maduras obtiveram-se menores rendimentos de minimilho que o obtido colhendo-se todas as espigas como minimilho. Economicamente, as melhores receitas líquidas seriam obtidas explorando-se a cultura para a produção de espigas verdes, espigas verdes + minimilho, minimilho, minimilho + grãos e grãos, nesta ordem

    Study of a desulfurization process to convert dibenzothiophene to 2-hydroxybiphenyl by Rhodococcus rhodochrous NRRL (B-2149)

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    [Abstract] Actually, a great effort is being given to research on biodesulfurization processes, i.e., processes in which sulfur can be removed selectively from sulfur-compound moities without altering its British thermal unit. This effort relies on the fact that fossil fuels (coal and oil) contain organic sulfur compounds that are released after combustion to the environment mainly as SO2 that causes acid rain becoming a potential pollutant. In this work we investigate the biodesulfurization of a model molecule that represents the main class of a group of recalcitrant compounds found in petroleum, Dibenzothiophene (DBT), to produce 2-Hydroxybiphenyl (2-HBP), a sulfur-free compound, by Rhodococcus rhodochrous (NRRL B-2149) using the 4S pathway. Experiments in which R. rhodochrous (NRRL B- 2149) was cultived during exponential growth phase using glucose and DBT as carbon and energy and sulfur sources, respectively, showed that the microorganism follows the 4S metabolic pathway in which DBT is converted to 2-HBP and sulfite. It was also showed that R. rhodochrous (NRRL B-2149) has cell-bounding surface active agents that that facilitates the emulsification of the apolar – water immiscible DBT

    GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection

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    Cellular necrosis during Mycobacterium tuberculosis (Mtb) infection promotes both immunopathology and bacterial dissemination. Glutathione peroxidase-4 (Gpx4) is an enzyme that plays a critical role in preventing iron-dependent lipid peroxidation–mediated cell death (ferroptosis), a process previously implicated in the necrotic pathology seen in Mtb-infected mice. Here, we document altered GPX4 expression, glutathione levels, and lipid peroxidation in patients with active tuberculosis and assess the role of this pathway in mice genetically deficient in or overexpressing Gpx4. We found that Gpx4-deficient mice infected with Mtb display substantially increased lung necrosis and bacterial burdens, while transgenic mice overexpressing the enzyme show decreased bacterial loads and necrosis. Moreover, Gpx4-deficient macrophages exhibited enhanced necrosis upon Mtb infection in vitro, an outcome suppressed by the lipid peroxidation inhibitor, ferrostatin-1. These findings provide support for the role of ferroptosis in Mtb-induced necrosis and implicate the Gpx4/GSH axis as a target for host-directed therapy of tuberculosis
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