Entropy Projection Curved Gabor with Random Forest and SVM for Face Recognition

In this work, we propose a workflow for face recognition under occlusion using the entropy projection from the curved Gabor filter, and create a representative and compact features vector that describes a face. Despite the reduced vector obtained by the entropy projection, it still presents opportunity for further dimensionality reduction. Therefore, we use a Random Forest classifier as an attribute selector, providing a 97% reduction of the original vector while keeping suitable accuracy. A set of experiments using three public image databases: AR Face, Extended Yale B with occlusion and FERET illustrates the proposed methodology, evaluated using the SVM classifier. The results obtained in the experiments show promising results when compared to the available approaches in the literature, obtaining 98.05% accuracy for the complete AR Face, 97.26% for FERET and 81.66% with Yale with 50% occlusion

Report on the BTAS 2016 Video Person Recognition Evaluation

© 2016 IEEE. This report presents results from the Video Person Recognition Evaluation held in conjunction with the 8th IEEE International Conference on Biometrics: Theory, Applications, and Systems (BTAS). Two experiments required algorithms to recognize people in videos from the Point-and-Shoot Face Recognition Challenge Problem (PaSC). The first consisted of videos from a tripod mounted high quality video camera. The second contained videos acquired from 5 different handheld video cameras. There were 1,401 videos in each experiment of 265 subjects. The subjects, the scenes, and the actions carried out by the people are the same in both experiments. An additional experiment required algorithms to recognize people in videos from the Video Database of Moving Faces and People (VDMFP). There were 958 videos in this experiment of 297 subjects. Four groups from around the world participated in the evaluation. The top verification rate for PaSC from this evaluation is 0.98 at a false accept rate of 0.01 - a remarkable advancement in performance from the competition held at FG 2015

Cellular binding partners of the human papillomavirus E6 protein

The high-risk strains of human papillomavirus (HR-HPV) are known to be causative agents of cervical cancer and have recently also been implicated in cancers of the oropharynx. E6 is a potent oncogene of HR-HPVs, and its role in the progression to malignancy has been and continues to be explored. E6 is known to interact with and subsequently inactivate numerous cellular proteins pivotal in the mediation of apoptosis, transcription of tumor suppressor genes, maintenance of epithelial organization, and control of cell proliferation. Binding of E6 to these proteins cumulatively contributes to the oncogenic potential of HPV. This paper provides an overview of these cellular protein partners of HR-E6, the motifs known to mediate oncoprotein binding, and the agents that have the potential to interfere with E6 expression and activity and thus prevent the subsequent progression to oncogenesis

Acanthus montanus: An experimental evaluation of the antimicrobial, anti-inflammatory and immunological properties of a traditional remedy for furuncles

<p>Abstract</p> <p>Background</p> <p><it>Acanthus montanus </it>(Nees) T. Anderson (Acanthaceae) is a shrub widespread in Africa, the Balkans, Romania, Greece and Eastern Mediterranean. It is used in African traditional medicine for the treatment of urogenital infections, urethral pain, endometritis, urinary disease, cystitis, leucorrhoea, aches and pains. In southeastern Nigeria, the root is popular and acclaimed highly effective in the treatment of furuncles. This study was undertaken to experimentally evaluate the antimicrobial and anti-inflammatory properties of the root extract as well as its effect on phagocytosis and specific cell-mediated immune response which may underlie the usefulness of the roots in treatment of furuncles.</p> <p>Methods</p> <p>The aqueous root extract (obtained by hot water maceration of the root powder) was studied for effects on the growth of clinically isolated strains of <it>Pseudomonas aeruginosa </it>and <it>Staphylococcus aureus</it>. The anti-inflammatory activity was investigated using acute topical edema of the mouse ear induced by xylene, acute paw edema induced by agar in rats, formaldehyde arthritis in rats, vascular permeability induced by acetic acid in mice and heat- and hypotonicity-induced haemolysis of ox red blood cells (RBCs). Also evaluated were the effects on <it>in vivo </it>leukocyte migration induced by agar, phagocytic activity of macrophages on <it>Candida albicans </it>and specific cell-mediated immune responses (delayed type hypersensitivity reaction (DTHR) induced by sheep red blood cell (SRBC)). The acute toxicity and lethality (LD₅₀) in mice and phytochemical constituents of the extract were also determined.</p> <p>Results</p> <p>The extract moderately inhibited the growth of the test organisms and significantly (<it>P </it>< 0.05) inhibited (57%) topical acute edema in the mouse ear. It significantly (<it>P </it>< 0.05) suppressed the development of acute edema of the rat paw in a non-dose-related manner and was not effective in inhibiting the global edematous response to formaldehyde arthritis. It also inhibited vascular permeability induced by acetic acid in mice and the haemolysis of ox RBCs induced by heat- and hypotonicity. The extract increased total leukocyte and neutrophil counts and caused a significant (<it>P </it>< 0.05) dose-related increase in the total number of macrophages at the 800 mg/kg dose. On phagocytic activity, the extract evoked a significant (<it>P </it>< 0.05) increase in the number of macrophages with ingested <it>C. albicans </it>at 800 mg/kg dose, and significantly (<it>P </it>< 0.05) inhibited DTHR in a dose-related manner. Phytochemical tests on the extract revealed an abundant presence of alkaloids and carbohydrates while saponins, glycosides, and terpenoids occurred in trace amounts. Acute toxicity test established an oral and intraperitoneal LD₅₀greater than 5,000 mg/kg.</p> <p>Conclusion</p> <p>The effectiveness of the root of <it>A. montanus </it>in the treatment of furuncles may largely derive from mobilization of leukocytes to the site of the infection and activation of phagocytic activity as well as suppression of exacerbated immune responses by its constituents. Antimicrobial and anti-inflammatory activities are likely contributory mechanisms. Phytochemical constituents such as alkaloids and carbohydrates may be responsible for these pharmacological activities.</p

A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells

High-risk human papillomaviruses (HR-HPVs) are the causative agents for the onset of several epithelial cancers in humans. The deregulated expression of the viral oncoproteins E6 and E7 is the driving force sustaining the progression of malignant transformation in pre-neoplastic lesions. Targeting the viral E6 oncoprotein through inhibitory compounds can counteract the survival of cancer cells due to the reactivation of p53-mediated pathways and represents an intriguing strategy to treat HPV-associated neoplasias. Here, we describe the development of a quantitative and easy-to-perform assay to monitor the E6-mediated degradation of p53 in living cells to be used for small-molecule testing. This assay allows to unbiasedly determine whether a compound can protect p53 from the E6-mediated degradation in cells, through a simple 3-step protocol. We validated the assay by testing two small molecules, SAHA and RITA, reported to impair the E6-mediated p53 degradation. Interestingly, we observed that only SAHA efficiently rescued p53, while RITA could not provide the same degree of protection. The possibility to specifically and quantitatively monitor the ability of a selected compound to rescue p53 in a cellular context through our LumiFluo assay could represent an important step towards the successful development of anti-HPV drugs

Evolutionary significance of inversions in legume chloroplast DNAs

Cloned genes from tobacco, spinach, and pea were used as hybridization probes to localize 36 protein genes on the chloroplast chromosomes of four legumes — mung bean, common bean, soybean, and pea. The first three chloroplast DNAs (cpDNAs), all of which retain a large inverted repeat, have an identical gene order with but one exception. A 78 kb segment encompassing nearly the entire large single copy region is inverted in mung bean and common bean relative to soybean and non-legumes. The simplest evolutionary explanation for this difference is a 78 kb inversion, with one endpoint between rps8 and inf A and the second between psb A and rpl2 . However, we can not rule out a two-step re-arrangement (consisting of successive expansion and contraction of the inverted repeat) leading to the relocation of a block of six ribosomal protein genes ( rps 19- rps 8) from one end of the large single copy region to the other. Analysis of gene locations in pea cpDNA, which lacks the large inverted repeat, combined with cross-hybridization studies using 59 clones covering the mung bean genome, leads to a refined picture of the position and nature of the numerous rearrangements previously described in the pea genome. A minimum of eight large inversions are postulated to account for these rearrangements. None of these inversions disrupt groups of genes that are transcriptionally linked in angiosperm cpDNA. Rather, the end-points of inversions are associated with relatively spacer-rich segments of the genome, many of which contain tRNA genes. All of the pea-specific inversions are shown to be positionally distinct from those recently described in a closely related legume, broad bean.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46965/1/294_2004_Article_BF00405856.pd

2D Bragg high power microwave source driven by an annular electron beam

The first successful cold microwave measurements of a 2D Bragg coaxial mirror were discussed. An important difference between 1D and 2D Bragg structures was demonstrated concerning the dependence of their reflection coefficient on the parameter αlz, where α denotes wave coupling coefficient and lz represents length. The minimum of the transmission was found to be the same for the 2D structures. The possibility of achieving single mode operation was also demonstrated for the Free Electron Masers (FEM) when driven by an oversized electron beam with D/λ∼25, where D denotes diameter of the microwave system used and λ stands for wavelength of radiation

Influence of different angles of file access on cyclic fatigue resistance of 2shape rotary instruments in different artificial canals

Aim: Several parameters including extent of the curvature and angulated insertion of file into the canal could influence cyclic fatigue of nickel-titanium files. The purpose of this study was to compare the influence of different access angles associated to different curvature radii on cyclic fatigue resistance of 2Shape (TS; Micro-Mega, Besancon, France) rotary instruments. Methods: 60 instruments were tested in two 16mm- stainless steel artificial canals with angle of curvature of 60° and 5mm or 3mm radius of curvature respectively. 2Shape TS2 #25.06 and 2Shape TS1 #25.04 were evaluated at 0°, 10° and 20° insertion angles (n=10 for each angle of access). Cyclic fatigue resistance was determined by Number of Cycles to Failure (NCF) using a new testing device machine. This device consists of a platform composed of a block containing the electric handpiece and a mobile support on rails for insertion/disconnection of the file. Moreover, a metal mobile platform is connected to the mobile support. This second platform with the artificial canal produces the different inclination of insertion of tested file maintaining the entrance of instrument perpendicular to the canal. Each instrument was tested in continuous rotation (300 rpm) following the manufacturer’s instructions. Fracture surface was examined with a scanning electron microscope. Data were statistically analyzed using 2-way analysis of variance and the Bonferroni multiple comparison post-hoc test (Prism 7.0; GraphPad Software, Inc, La Jolla, CA) with a significance level of P&lt;0.05. Results: TS1 (#25.04) exhibited higher cyclic fatigue resistance than TS2 (#25.06) for each angle and radius tested (P&lt;0.05). When files were tested inside 3mm- radius canal, independently from taper, they recorded lower cyclic fatigue resistance than in 5mm-radius one (P&lt;0.05). Considering canal with 5mm-radius of curvature, no significant cyclic fatigue resistance reduction was observed for .06 taper-instruments for each angle tested (P&gt;0.05), while files with .04 taper exhibited significant lower NCF when tested at 20° (P&lt;0.05). In canals with 3mm radius of curvature, TS2 (#25.06) showed no significant differences for each angle tested (P&gt;0.05). TS1 (#25.04) exhibited significant resistance reduction between 0° and 10° as well as between 0° and 20° (P&lt;0.05), with no difference between 10° and 20° (P&gt;0.05). Conclusion: Inclined angle of file access into the canals decreased cyclic fatigue resistance of #25.04 files especially when the radius of curvature is reduced. Cyclic fatigue resistance of #25.04 instruments was higher than #25.06 files made with the same thermal treatment. Independently from taper, each file tested in 3mm-radius canal showed lower cyclic fatigue resistance than instruments tested in 5mm-radius canal