2,180 research outputs found
Viking navigation
A comprehensive description of the navigation of the Viking spacecraft throughout their flight from Earth launch to Mars landing is given. The flight path design, actual inflight control, and postflight reconstruction are discussed in detail. The preflight analyses upon which the operational strategies and performance predictions were based are discussed. The inflight results are then discussed and compared with the preflight predictions and, finally, the results of any postflight analyses are presented
Analytic binary alloy volume-concentration relations and the deviation from Zen`s law
Alloys expand or contract as concentrations change, and the resulting
relationship between atomic volume and alloy content is an important property
of the solid. While a well-known approximation posits that the atomic volume
varies linearly with concentration (Zen`s law), the actual variation is more
complicated. Here we use an apparent size of the solute (solvent) atom and the
elasticity to derive explicit analytical expressions for the atomic volume of
binary solid alloys. Two approximations, continuum and terminal, are proposed.
Deviations from Zen`s law are studied for 22 binary alloy systems
OmniMapFree: A unified tool to visualise and explore sequenced genomes
<p>Abstract</p> <p>• Background</p> <p>Acquiring and exploring whole genome sequence information for a species under investigation is now a routine experimental approach. On most genome browsers, typically, only the DNA sequence, EST support, motif search results, and GO annotations are displayed. However, for many species, a growing volume of additional experimental information is available but this is rarely searchable within the landscape of the entire genome.</p> <p>• Results</p> <p>We have developed a generic software which permits users to view a single genome in entirety either within its chromosome or supercontig context within a single window. This software permits the genome to be displayed at any scales and with any features. Different data types and data sets are displayed onto the genome, which have been acquired from other types of studies including classical genetics, forward and reverse genetics, transcriptomics, proteomics and improved annotation from alternative sources. In each display, different types of information can be overlapped, then retrieved in the desired combinations and scales and used in follow up analyses. The displays generated are of publication quality.</p> <p>• Conclusions</p> <p>OmniMapFree provides a unified, versatile and easy-to-use software tool for studying a single genome in association with all the other datasets and data types available for the organism.</p
Half-Metallic Ferrimagnetism in Mn_2VAl
We show that Mn_2VAl is a compound for which the generalized gradient
approximation (GGA) to the exchange-correlation functional in density
functional theory makes a qualitative change in predicted behavior compared to
the usual local density approximation (LDA). Application of GGA leads to
prediction of Mn_2VAl being a half-metallic ferrimagnet, with the minority
channel being the conducting one. The electronic and magnetic structure is
analyzed and contrasted with the isostructural enhanced semimetal Fe_2VAl.Comment: 5 pages, Latex, 6 postscript figures. Description and figures of the
(minority) Fermi surfaces have been adde
Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists
PURPOSE: The ferret cisplatin emesis model has been used for ~30 years and enabled identification of clinically used anti-emetics. We provide an objective assessment of this model including efficacy of 5-HT(3) receptor antagonists to assess its translational validity. METHODS: A systematic review identified available evidence and was used to perform meta-analyses. RESULTS: Of 182 potentially relevant publications, 115 reported cisplatin-induced emesis in ferrets and 68 were included in the analysis. The majority (n = 53) used a 10 mg kg(−1) dose to induce acute emesis, which peaked after 2 h. More recent studies (n = 11) also used 5 mg kg(−1), which induced a biphasic response peaking at 12 h and 48 h. Overall, 5-HT(3) receptor antagonists reduced cisplatin (5 mg kg(−1)) emesis by 68% (45–91%) during the acute phase (day 1) and by 67% (48–86%) and 53% (38–68%, all P < 0.001), during the delayed phase (days 2, 3). In an analysis focused on the acute phase, the efficacy of ondansetron was dependent on the dosage and observation period but not on the dose of cisplatin. CONCLUSION: Our analysis enabled novel findings to be extracted from the literature including factors which may impact on the applicability of preclinical results to humans. It reveals that the efficacy of ondansetron is similar against low and high doses of cisplatin. Additionally, we showed that 5-HT(3) receptor antagonists have a similar efficacy during acute and delayed emesis, which provides a novel insight into the pharmacology of delayed emesis in the ferret
Single Spin Superconductivity: Formulation and Ginzburg-Landau Theory
We describe a novel superconducting phase that arises due to a pairing
instability of the half-metallic antiferromagnetic (HM AFM) normal state. This
single spin superconducting (SSS) phase contains broken time reversal symmetry
in addition to broken gauge symmetry, the former due to the underlying magnetic
order in the normal state. A classification of normal state symmetries leads to
the conclusion that the HM AFM normal phase whose point group contains the
inversion operator contains the least symmetry possible which still allows for
a zero momentum pairing instability. The Ginzburg-Landau free energy for the
superconducting order parameter is constructed consistent with the symmetry of
the normal phase, electromagnetic gauge invariance and the crystallographic
point group symmetry including inversion. For cubic, hexagonal and tetragonal
point groups, the possible symmetries of the superconducting phase are
classified, and the free energy is used to construct a generalized phase
diagram. We identify the leading candidate out of the possible SSS phases for
each point group. The symmetry of the superconducting phase is used to
determine the cases where the gap function has generic zeros (point or line
nodes) on the Fermi surface. Such nodes always occur, hence thermodynamic
properties will have power-law behavior at low temperature.Comment: 39 pages, RevTeX, 4 PostScript figures included, submitted to Phys.
Rev.
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