The Chandra X-ray Observatory Resolves the X-ray Morphology and Spectra of a Jet in PKS 0637-752

The core-dominated radio-loud quasar PKS 0637-752 (z = 0.654) was the first celestial object observed with the Chandra X-ray Observatory, offering the early surprise of the detection of a remarkable X-ray jet. Several observations with a variety of detector configurations contribute to a total exposure time with the Chandra Advanced CCD Imaging Spectrometer (ACIS; Garmire et al. 2000, in preparation) of about 100ks. A spatial analysis of all the available X-ray data, making use of Chandra's spatial resolving power of about 0.4 arcsec, reveals a jet that extends about 10 arcsec to the west of the nucleus. At least four X-ray knots are resolved along the jet, which contains about 5% of the overall X-ray luminosity of the source. Previous observations of PKS 0637-752 in the radio band (Tingay et al. 1998) had identified a kpc-scale radio jet extending to the West of the quasar. The X-ray and radio jets are similar in shape, intensity distribution, and angular structure out to about 9 arcsec, after which the X-ray brightness decreases more rapidly and the radio jet turns abruptly to the north. The X-ray luminosity of the total source is log Lx ~ 45.8 erg/s (2 - 10keV), and appears not to have changed since it was observed with ASCA in November 1996. We present the results of fitting a variety of emission models to the observed spectral distribution, comment on the non-existence of emission lines recently reported in the ASCA observations of PKS 0637-752, and briefly discuss plausible X-ray emission mechanisms.Comment: 24 pages, includes 8 figures, Accepted for publication in Ap

Gluon-induced W-boson pair production at the LHC

Pair production of W bosons constitutes an important background to Higgs boson and new physics searches at the Large Hadron Collider LHC. We have calculated the loop-induced gluon-fusion process gg -> W*W* -> leptons, including intermediate light and heavy quarks and allowing for arbitrary invariant masses of the W bosons. While formally of next-to-next-to-leading order, the gg -> W*W* -> leptons process is enhanced by the large gluon flux at the LHC and by experimental Higgs search cuts, and increases the next-to-leading order WW background estimate for Higgs searches by about 30%. We have extended our previous calculation to include the contribution from the intermediate top-bottom massive quark loop and the Higgs signal process. We provide updated results for cross sections and differential distributions and study the interference between the different gluon scattering contributions. We describe important analytical and numerical aspects of our calculation and present the public GG2WW event generator.Comment: 20 pages, 4 figure

An update on vector boson pair production at hadron colliders

We present numerical results (including full one-loop QCD corrections) for the processes p p-bar and pp -> W+ W-, W+/- Z/gamma* and Z/gamma* Z/gamma* followed by the decay of the massive vector bosons into leptons. In addition to their intrinsic importance as tests of the standard model, these processes are also backgrounds to conjectured non-standard model processes. Because of the small cross sections at the Tevatron, full experimental control of these backgrounds will be hard to achieve. This accentuates the need for up-to-date theoretical information. A comparison is made with earlier work and cross section results are presented for p p-bar collisions at sqrt{s}=2 TeV and pp collisions at sqrt{s}=14 TeV. Practical examples of the use of our calculations are presented.Comment: 18 pages, 5 embedded figures, included extra reference [7

Vector Boson Pair Production in Hadronic Collisions at Order αs\alpha_s: Lepton Correlations and Anomalous Couplings

We present cross sections for production of electroweak vector boson pairs, $WW$, $WZ$ and $ZZ$, in $p\bar{p}$ and $pp$ collisions, at next-to-leading order in $\alpha_s$. We treat the leptonic decays of the bosons in the narrow-width approximation, but retain all spin information via decay angle correlations. We also include the effects of $WWZ$ and $WW\gamma$ anomalous couplings.Comment: 23 pages, 8 figures, 3 table

Constraint on the heavy sterile neutrino mixing angles in the SO(10) model with double see-saw mechanism

Constraints on the heavy sterile neutrino mixing angles are studied in the framework of a minimal supersymmetric ${\rm SO}(10)$ model with {\it double see-saw mechanism}. A new singlet matter in addition to the right-handed neutrinos is introduced to realize the double see-saw mechanism. The minimal ${\rm SO}(10)$ model gives an unambiguous Dirac neutrino mass matrix, which enables us to predict the masses and the mixing angles in the enlarged $9 \times 9$ neutrino mass matrix. Mixing angles between the light Majorana neutrinos and the heavy sterile neutrinos are shown to be within the LEP experimental bound on all ranges of the Majorana phases.Comment: 16 pages, 4 figures; the version to be published in Eur. Phys. J.

Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP

Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2). The hormone binds to vasopressin V2 receptors (V2R) on the surface of the cells and stimulates cAMP synthesis. The cAMP activates protein kinase A (PKA), which initiates signaling that causes an accumulation of AQP2 in the plasma membrane of the cells facilitating water reabsorption from primary urine and fine-tuning of body water homeostasis. AVP-mediated PKA activation also causes an increase in the AQP2 protein abundance through a mechanism that involves dephosphorylation of AQP2 at serine 261 and a decrease in its poly-ubiquitination. However, the signaling downstream of PKA that controls the localization and abundance of AQP2 is incompletely understood. We carried out an siRNA screen targeting 719 kinase-related genes, representing the majority of the kinases of the human genome and analyzed the effect of the knockdown on AQP2 by high-content imaging and biochemical approaches. The screening identified 13 hits whose knockdown inhibited the AQP2 accumulation in the plasma membrane. Amongst the candidates was the so far hardly characterized cyclin-dependent kinase 18 (CDK18). Our further analysis revealed a hitherto unrecognized signalosome comprising CDK18, an E3 ubiquitin ligase, STUB1 (CHIP), PKA and AQP2 that controls the localization and abundance of AQP2. CDK18 controls AQP2 through phosphorylation at serine 261 and STUB1-mediated ubiquitination. STUB1 functions as an A-kinase anchoring protein (AKAP) tethering PKA to the protein complex and bridging AQP2 and CDK18. The modulation of the protein complex may lead to novel concepts for the treatment of disorders which are caused or are associated with dysregulated AQP2 and for which a satisfactory treatment is not available, e.g., hyponatremia, liver cirrhosis, diabetes insipidus, ADPKD or heart failure

Genome landscapes and bacteriophage codon usage

Across all kingdoms of biological life, protein-coding genes exhibit unequal usage of synonmous codons. Although alternative theories abound, translational selection has been accepted as an important mechanism that shapes the patterns of codon usage in prokaryotes and simple eukaryotes. Here we analyze patterns of codon usage across 74 diverse bacteriophages that infect E. coli, P. aeruginosa and L. lactis as their primary host. We introduce the concept of a `genome landscape,' which helps reveal non-trivial, long-range patterns in codon usage across a genome. We develop a series of randomization tests that allow us to interrogate the significance of one aspect of codon usage, such a GC content, while controlling for another aspect, such as adaptation to host-preferred codons. We find that 33 phage genomes exhibit highly non-random patterns in their GC3-content, use of host-preferred codons, or both. We show that the head and tail proteins of these phages exhibit significant bias towards host-preferred codons, relative to the non-structural phage proteins. Our results support the hypothesis of translational selection on viral genes for host-preferred codons, over a broad range of bacteriophages.Comment: 9 Color Figures, 5 Tables, 53 Reference

Z' signals in polarised top-antitop final states

We study the sensitivity of top-antitop samples produced at all energy stages of the Large Hadron Collider (LHC) to the nature of an underlying Z' boson, in presence of full tree level standard model (SM) background effects and relative interferences. We concentrate on differential mass spectra as well as both spatial and spin asymmetries thereby demonstrating that exploiting combinations of these observables will enable one to distinguish between sequential Z's and those pertaining to Left-Right symmetric models as well as E6 inspired ones, assuming realistic final state reconstruction efficiencies and error estimates.Comment: 21 pages, 6 colour figures, 10 table

Compulsive buying and branding phenomena

The purpose of this paper was to explore the impact of brand variables such as brand awareness, brand loyalty, brand attachment, and perceived brand quality on compulsive buying behavior. A self-administered questionnaire, containing demographic items and items related to compulsive buying, brand awareness, brand loyalty, brand attachment and perceived quality, was used to collect data. Participants were 269 US university students at a large mid-western university (138 men, 131 women; mean age = 21.96). Data were analyzed using descriptive statistics, t-test and MANOVA/ANOVA. Reliability of all scales was acceptable. In the current study, 18% of the participants were classified as compulsive buyers. Women showed higher compulsive buying tendency than men. Participants with greater compulsive buying tendency scored higher on brand attachment and brand loyalty and lower on brand awareness; there was no difference in scores on perceived brand quality. Results support that brand variables such as brand awareness, brand loyalty, and brand attachment are related to compulsive buying behavior. New perceptions and implications for both academicians and practitioners are provided