Simultaneous X-ray/optical observations of GX 9+9 (4U 1728-16)

We report on the results of the first simultaneous X-ray (RXTE) and optical (SAAO) observations of the luminous low mass X-ray binary (LMXB) GX 9+9 in 1999 August. The high-speed optical photometry revealed an orbital period of 4.1958 hr and confirmed previous observations, but with greater precision. No X-ray modulation was found at the orbital period. On shorter timescales, a possible 1.4-hr variability was found in the optical light curves which might be related to the mHz quasi-periodic oscillations seen in other LMXBs. We do not find any significant X-ray/optical correlation in the light curves. In X-rays, the colour-colour diagram and hardness-intensity diagram indicate that the source shows characteristics of an atoll source in the upper banana state, with a correlation between intensity and spectral hardness. Time-resolved X-ray spectroscopy suggests that two-component spectral models give a reasonable fit to the X-ray emission. Such models consist of a blackbody component which can be interpreted as the emission from an optically thick accretion disc or an optically thick boundary layer, and a hard Comptonized component for an extended corona.Comment: 19 pages, 13 figures; accepted for publication in MNRA

Clinical guidelines for caring for women with COVID-19 during pregnancy, childbirth and the immediate postpartum period.

BACKGROUND:The spread of the novel coronavirus (COVID-19) was declared a pandemic by the World Health Organization on 11th March 2020. Since then there has been a rapid rise in development of maternal and perinatal health guidelines related to COVID-19. The aim of this project was to develop a database of Australian and international recommendations relating to antenatal, intrapartum and postpartum care of women during the COVID-19 pandemic, in order to identify inconsistencies in clinical guidance. METHODS:We conducted weekly web searches from 30th March to 15th May 2020 to identify recommendations pertaining to the care of women during pregnancy, labour and postpartum period from national or international professional societies, specialist colleges, Ministries of Health, Australian state and territory governments, and international guideline development organisations. Individual recommendations were extracted and classified according to intervention type, time period, and patient population. Findings were reported using descriptive analysis, with areas of consensus and non-consensus identified. RESULTS:We identified 81 guidelines from 48 different organisations. Generally, there was high consensus across guidelines for specific interventions. However, variable guidance was identified on the use of nitrous oxide during labour, administration of antenatal corticosteroids, neonatal isolation after birth, labour and birth companions, and the use of disease modifying agents for treating COVID-19. CONCLUSION:Discrepancies between different guideline development organisations creates challenges for maternity care clinicians during the COVID-19 pandemic. Collating recommendations and keeping up-to-date with the latest guidance can help clinicians provide the best possible care to pregnant women and their babies

Affordable passive 3D-printed prosthesis for persons with partial hand amputation

Background and Aim: Partial hand amputations are common in developing countries and have a negative impact on patients and their families’ quality of life. The uniqueness of each partial hand amputation, coupled with the relatively high costs of prostheses, makes it challenging to provide suitable prosthetic solutions in developing countries. Current solutions often have long lead times and require a high level of expertise to produce. The aim of this study was to design and develop an affordable patient-specific partial hand prosthesis for developing countries. Technique: The prosthesis was designed for a patient with transmetacarpal amputation (i.e. three amputated fingers and partial palm). The final design was passive, controlled by the contralateral hand, and utilized the advanced flexibility properties of thermoplastic polyurethane in a glove-like design that costs approximately 20 USD to fabricate. Quantitative and qualitative tests were conducted to assess performance of the device after the patient used the final design. A qualitative assessment was performed to gather the patient’s feedback following a series of tests of grasp taxonomy. A quantitative assessment was performed through a grasp and lift test to measure the prosthesis’ maximum load capacity. Discussion: This study showed that the prosthesis enhanced the patient’s manual handling capabilities, mainly in the form of grasp stability. The prosthesis was light weight and could be donned and doffed by the patient independently. Limitations include the need to use the contralateral hand to achieve grasping and low grasp strength. Clinical relevance: Persons with partial hand amputation in developing countries lack access to affordable functional prostheses, hindering their ability to participate in the community. 3D-printed prostheses can provide a low-cost solution that is adaptable to different amputation configurations

Deviations from the Flux-Recurrence Time Relationship in GS 1826-238: Potential Transient Spectral Changes

The low-mass X-ray binary GS 1826-238 is presently unique for its consistently regular bursting behavior. In previous Rossi X-Ray Timing Explorer (RXTE) measurements between 1997 November and 2002 July, this source exhibited (nearly) limit-cycle bursts with recurrence times that decreased proportionately as the persistent flux increased. Here we report additional measurements of the burst recurrence time by RXTE, Chandra, and XMM-Newton, as well as observations of optical bursts. On a few occasions we measured burst recurrence times which deviated significantly from the earlier flux-recurrence time relationship, and most of these bursts occurred earlier than would be predicted based on the X-ray flux level. The epochs with early bursts were also accompanied by unusual broadband timing signatures, with the entire power spectrum shifting to higher frequencies. Concurrent XMM-Newton observations during one of these occasions, in 2003 April, indicate that an additional soft component may be present in the spectrum containing enough flux (30% of the total) to account for the burst recurrence time discrepancy. A self-consistent interpretation for the increase in soft flux and accompanying timing changes during 2003 April is that accretion disk extends down to smaller radial distances from the source than during the other observing epochs. The RXTE observations since 2003 April show that the spectral and timing properties have nearly returned to the previously established level.Comment: 10 pages, 9 figures, Accepted by Ap

Environmental changes and violent conflict

This letter reviews the scientific literature on whether and how environmental changes affect the risk of violent conflict. The available evidence from qualitative case studies indicates that environmental stress can contribute to violent conflict in some specific cases. Results from quantitative large-N studies, however, strongly suggest that we should be careful in drawing general conclusions. Those large-N studies that we regard as the most sophisticated ones obtain results that are not robust to alternative model specifications and, thus, have been debated. This suggests that environmental changes may, under specific circumstances, increase the risk of violent conflict, but not necessarily in a systematic way and unconditionally. Hence there is, to date, no scientific consensus on the impact of environmental changes on violent conflict. This letter also highlights the most important challenges for further research on the subject. One of the key issues is that the effects of environmental changes on violent conflict are likely to be contingent on a set of economic and political conditions that determine adaptation capacity. In the authors' view, the most important indirect effects are likely to lead from environmental changes via economic performance and migration to violent conflict. © 2012 IOP Publishing Ltd

New Insights into the Genetic Regulation of Homologue Disjunction in Mammalian Oocytes

Mammalian oocytes execute a unique meiotic programme involving 2 arrest stages and an unusually protracted preamble to chromosome segregation during the first meiotic division (meiosis I). How mammalian oocytes successfully navigate their exceptional meiotic journey has long been a question of immense interest. Understanding the minutiae of female mammalian meiosis I is not merely of academic interest as 80–90% of human aneuploidy is the consequence of errors arising at this particular stage of oocyte maturation, a stage with a peculiar vulnerability to aging. Recent evidence indicates that oocytes employ many of the same cast of proteins during meiosis I as somatic cells do during mitosis, often to execute similar tasks, but intriguingly, occasionally delegate them to unexpected and unprecedented roles. This is epitomised by the master cell-cycle regulon, the anaphase-promoting complex or cyclosome (APC/C), acting in concert with a critical APC/C-targeted surveillance mechanism, the spindle assembly checkpoint (SAC). Together, the APC/C and the SAC are among the most influential entities overseeing the fidelity of cell-cycle progression and the precision of chromosome segregation. Here I review the current status of pivotal elements underpinning homologue disjunction in mammalian oocytes including spindle assembly, critical biochemical anaphase-initiating events, APC/C activity and SAC signalling along with contemporary findings relevant to progressive oocyte SAC dysfunction as a model for age-related human aneuploidy

Long-Term Functionality of Rural Water Services in Developing Countries: A System Dynamics Approach to Understanding the Dynamic Interaction of Causal Factors

Research has shown that sustainability of rural water infrastructure in developing countries is largely affected by the dynamic and systemic interactions of technical, social, financial, institutional, and environmental factors that can lead to premature water system failure. This research employs systems dynamic modeling, which uses feedback mechanisms to understand how these factors interact dynamically to influence long-term rural water system functionality. To do this, the research first identified and aggregated key factors from literature, then asked water sector experts to indicate the polarity and strength between factors through Delphi and cross impact survey questionnaires, and finally used system dynamics modeling to identify and prioritize feedback mechanisms. The resulting model identified 101 feedback mechanisms that were dominated primarily by three and four-factor loops that contained some combination of the factors: Water System Functionality, Community, Financial, Government, Management, and Technology. These feedback mechanisms were then scored and prioritized, with the most dominant feedback mechanism identified as Water System Functionality – Community – Finance – Management. This research offers insight into the dynamic interaction of factors impacting sustainability of rural water infrastructure through the identification of these feedback mechanisms and makes a compelling case for future research to longitudinally investigate the interaction of these factors in various contexts

The Off State of GX 339-4

We report BeppoSAX and optical observations of the black hole candidate GX 339-4 during its X-ray `off' state in 1999. The broad-band (0.8-50 keV) X-ray emission can be fitted by a single power law with spectral index, \alpha ~1.6. The observed luminosity is 6.6e33 erg s^{-1} in the 0.5-10 keV band, which is at the higher end of the flux distribution of black hole soft X-ray transients in quiescence, comparable to that seen in GS 2023+338 and 4U 1630-47. An optical observation just before the BeppoSAX observation shows the source to be very faint at these wavelengths as well (B=20.1, V=19.2). By comparing with previously reported `off' and low states (LS), we conclude that the `off' state is actually an extension of the LS, i.e. a LS at lower intensities. We propose that accretion models such as the advection-dominated accretion flows are able to explain the observed properties in such a state.Comment: Accepted for publication in MNRA

Long‐Distance Natal Dispersal Is Relatively Frequent and Correlated with Environmental Factors in a Widespread Raptor

Dispersal is a critical process influencing population dynamics and responses to global change. Long‐distance dispersal (LDD) can be especially important for gene flow and adaptability, although little is known about the factors influencing LDD because studying large‐scale movements is challenging and LDD tends to be observed less frequently than shorter‐distance dispersal (SDD). We sought to understand patterns of natal dispersal at a large scale, specifically aiming to understand the relative frequency of LDD compared to SDD and correlates of dispersal distances. We used bird banding and encounter data for American kestrels (Falco sparverius) to investigate the effects of sex, migration strategy, population density, weather, year and agricultural land cover on LDD frequency, LDD distance and SDD distance in North America from 1961 to 2015. Nearly half of all natal dispersal (48.9%) was LDD (classified as \u3e30 km), and the likelihood of LDD was positively associated with the proportion of agricultural land cover around natal sites. Correlates of distance differed between LDD and SDD movements. LDD distance was positively correlated with latitude, a proxy for migration strategy, suggesting that migratory individuals disperse farther than residents. Distance of LDD in males was positively associated with maximum summer temperature. We did not find sex‐bias or an effect of population density in LDD distance or frequency. Within SDD, females tended to disperse farther than males, and distance was positively correlated with density. Sampling affected all responses, likely because local studies more frequently capture SDD within study areas. Our findings that LDD occurs at a relatively high frequency and is related to different proximate factors from SDD, including a lack of sex‐bias in LDD, suggest that LDD may be more common than previously reported, and LDD and SDD may be distinct processes rather than two outcomes originating from a single dispersal distribution. To our knowledge, this is the first evidence that LDD and SDD may be separate processes in an avian species, and suggests that environmental change may have different outcomes on the two processes