Holistic Small Cell Traffic Balancing across Licensed and Unlicensed Bands

Due to the dramatic growth in mobile data traffic on one hand and the scarcity of the licensed spectrum on the other hand, mobile operators are considering the use of unlicensed bands (especially those in 5 GHz) as complementary spectrum for providing higher system capacity and better user experience. This approach is currently being standardized by 3GPP under the name of LTE Licensed-Assisted Access (LTE-LAA). In this paper, we take a holistic approach for LTE-LAA small cell traffic balancing by jointly optimizing the use of the licensed and unlicensed bands. We pose this traffic balancing as an optimization problem that seeks proportional fair coexistence of WiFi, small cell and macro cell users by adapting the transmission probability of the LTE-LAA small cell in the licensed and unlicensed bands. The motivation for this formulation is for the LTE-LAA small cell to switch between or aggregate licensed and unlicensed bands depending on the interference/traffic level and the number of active users in each band. We derive a closed form solution for this optimization problem and additionally propose a transmission mechanism for the operation of the LTE-LAA small cell on both bands. Through numerical and simulation results, we show that our proposed traffic balancing scheme, besides enabling better LTE-WiFi coexistence and efficient utilization of the radio resources relative to the existing traffic balancing scheme, also provides a better tradeoff between maximizing the total network throughput and achieving fairness among all network flows compared to alternative approaches.Comment: Accepted for publication at MSWiM 201

Serial bone marrow transplantation reveals in vivo expression of the pCLPG retroviral vector

<p>Abstract</p> <p>Background</p> <p>Gene therapy in the hematopoietic system remains promising, though certain aspects of vector design, such as transcriptional control elements, continue to be studied. Our group has developed a retroviral vector where transgene expression is controlled by p53 with the intention of harnessing the dynamic and inducible nature of this tumor suppressor and transcription factor. We present here a test of <it>in vivo </it>expression provided by the p53-responsive vector, pCLPG. For this, we used a model of serial transplantation of transduced bone marrow cells.</p> <p>Results</p> <p>We observed, by flow cytometry, that the eGFP transgene was expressed at higher levels when the pCLPG vector was used as compared to the parental pCL retrovirus, where expression is directed by the native MoMLV LTR. Expression from the pCLPG vector was longer lasting, but did decay along with each sequential transplant. The detection of eGFP-positive cells containing either vector was successful only in the bone marrow compartment and was not observed in peripheral blood, spleen or thymus.</p> <p>Conclusions</p> <p>These findings indicate that the p53-responsive pCLPG retrovirus did offer expression <it>in vivo </it>and at a level that surpassed the non-modified, parental pCL vector. Our results indicate that the pCLPG platform may provide some advantages when applied in the hematopoietic system.</p

LNCaP Atlas: Gene expression associated with in vivo progression to castration-recurrent prostate cancer

<p>Abstract</p> <p>Background</p> <p>There is no cure for castration-recurrent prostate cancer (CRPC) and the mechanisms underlying this stage of the disease are unknown.</p> <p>Methods</p> <p>We analyzed the transcriptome of human LNCaP prostate cancer cells as they progress to CRPC <it>in vivo </it>using replicate LongSAGE libraries. We refer to these libraries as the LNCaP atlas and compared these gene expression profiles with current suggested models of CRPC.</p> <p>Results</p> <p>Three million tags were sequenced using <it>in vivo </it>samples at various stages of hormonal progression to reveal 96 novel genes differentially expressed in CRPC. Thirty-one genes encode proteins that are either secreted or are located at the plasma membrane, 21 genes changed levels of expression in response to androgen, and 8 genes have enriched expression in the prostate. Expression of 26, 6, 12, and 15 genes have previously been linked to prostate cancer, Gleason grade, progression, and metastasis, respectively. Expression profiles of genes in CRPC support a role for the transcriptional activity of the androgen receptor (<it>CCNH, CUEDC2, FLNA, PSMA7</it>), steroid synthesis and metabolism (<it>DHCR24, DHRS7</it>, <it>ELOVL5, HSD17B4</it>, <it>OPRK1</it>), neuroendocrine (<it>ENO2, MAOA, OPRK1, S100A10, TRPM8</it>), and proliferation (<it>GAS5</it>, <it>GNB2L1</it>, <it>MT-ND3</it>, <it>NKX3-1</it>, <it>PCGEM1</it>, <it>PTGFR</it>, <it>STEAP1</it>, <it>TMEM30A</it>), but neither supported nor discounted a role for cell survival genes.</p> <p>Conclusions</p> <p>The <it>in vivo </it>gene expression atlas for LNCaP was sequenced and support a role for the androgen receptor in CRPC.</p

Protocols for The Meeting Businessmen Problem

Assume that some businessmen wish to have a meeting. For this to occur, they usually have to meet somewhere. If they cannot meet physically, then they can take part in a video (or audio) conference to discuss whatever needs to be discussed. But what if their meeting is meant to be private? In this case they need a cryptographic protocol that allows them to exchange their ideas remotely, while keeping them secure from any potential eavesdropper. In this paper we list all the necessary requirements that a cryptographic protocol must have in order to allow several businessmen to exchange their ideas securely over the Internet. Moreover, and based on the standard taxonomy of cryptographic protocols, we suggest several approaches on how to design cryptographic protocols that enable us to achieve our aim. Finally, we propose the design of a protocol that solves the meeting businessmen problem

Dynamic Key Generation During a Communication Instance Over GSM

Mobile phone may become the protagonist of the new electronic technology. If we compare it with that of other technologies, the infiltration rate of mobile phones in the world is extremely high, both in cities than rural communities of the most of the countries. According to estimates made by the International Telecommunication Union the access to mobile networks is growing much faster than the access to Internet. This emergence has led many companies to allow new activities which were previously running strictly over the Internet to run over the mobile network such as the electronic payment. These circumstances make the security of mobile communication a priority to preserve the authentication, confidentiality and integrity of data sent between subscribers and mobile network. In this paper, we propose a dynamic key generation for the A5 GSM encryption algorithm to enforce the security and protect the transferred data. Our algorithm can be implemented over any GSM generation GSM/3G/4G