3 research outputs found
Tract-based Spatial Statistics and fMRI Analysis in Patients with Small Cell Lung Cancer before Prophylactic Cranial Irradiation
Prophylactic cranial irradiation (PCI) is known to increase life
expectancy to a significant degree in Small Cell Lung Cancer (SCLC)
patients. The overall scope of this research is to investigate changes
in structural and functional connectivity between SCLC patients and
controls before and after PCI treatment. In the current study
specifically we use diffusion tensor imaging (DTI) and functional
Magnetic Resonance (fMRI) to identify potential alterations in white
matter structure and brain function respectively, in SCLC patients
before PCI compared to healthy participants. The results in DTI analysis
have showed lower fractional anisotropy (FA) and higher eigenvalues in
white matter regions in the patient group. Similarly, in fMRI analysis a
lower level of activation in the primary somatosensory cortex was
reported. The results presented herein are subject to further
investigation with larger patient and control groups
Analysis of resting state and task-related fMRI data in small cell lung cancer patients before undertaking PCI
As the use of prophylactic cranial irradiation (PCI) increases life
expectancy in certain types of cancer, there is evidence that this
technique may contribute to neurocognitive deficits. The aim of this
research is to investigate functional connectivity in patients before
and after being administered brain radiotherapy as well as their
neurocognitive functionality, depending on the course of disease and the
phase of treatment and time of clinical examination. In the current
study we attempt to identify potential alterations in brain function
during resting state and task-related functional magnetic resonance
imaging (fMRI) in small cell lung cancer patients (SCLC) patients before
PCI compared to healthy subjects. The brain regions that were activated
for both groups during a sequential tapping task are consistent with
previous studies. However, the patient group showed a lower level of
activation in the primary somatosensory cortex bilaterally. During rest,
the Default Mode Network (DMN) was identified in both groups. The
results presented are subject to further investigation with larger
patient and control group