26 research outputs found
Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial
<p>Abstract</p> <p>Background</p> <p>Endothelial dysfunction has been proposed as the underlying cause of diabetic angiopathy that eventually leads to cardiovascular disease, the major cause of death in diabetes. We recently demonstrated the ameliorating effect of regular vitamin D intake on the glycemic status of patients with type 2 diabetes (T2D). In this study, the effects of improvement of vitamin D status on glycemic status, lipid profile and endothelial biomarkers in T2D subjects were investigated.</p> <p>Methods</p> <p>Subjects with T2D were randomly allocated to one of the two groups to receive either plain yogurt drink (PYD; containing 170 mg calcium and no vitamin D/250 mL, n<sub>1 </sub>= 50) or vitamin D3-fortified yogurt drink (FYD; containing 170 mg calcium and 500 IU/250 mL, n<sub>2 </sub>= 50) twice a day for 12 weeks. Anthropometric measures, glycemic status, lipid profile, body fat mass (FM) and endothelial biomarkers including serum endothelin-1, E-selectin and matrix metalloproteinase (MMP)-9 were evaluated at the beginning and after the 12-week intervention period.</p> <p>Results</p> <p>The intervention resulted in a significant improvement in fasting glucose, the Quantitative Insulin Check Index (QUICKI), glycated hemoglobin (HbA1c), triacylglycerols, high-density lipoprotein cholesterol (HDL-C), endothelin-1, E-selectin and MMP-9 in FYD compared to PYD (<it>P </it>< 0.05, for all). Interestingly, difference in changes of endothelin-1, E-selectin and MMP-9 concentrations in FYD compared to PYD (-0.35 ± 0.63 versus -0.03 ± 0.55, <it>P </it>= 0.028; -3.8 ± 7.3 versus 0.95 ± 8.3, <it>P </it>= 0.003 and -2.3 ± 3.7 versus 0.44 ± 7.1 ng/mL, respectively, <it>P </it>< 0.05 for all), even after controlling for changes of QUICKI, FM and waist circumference, remained significant for endothelin-1 and MMP-9 (<it>P </it>= 0.009 and <it>P </it>= 0.005, respectively) but disappeared for E-selectin (<it>P </it>= 0.092). On the contrary, after controlling for serum 25(OH)D, the differences disappeared for endothelin-1(<it>P </it>= 0.066) and MMP-9 (<it>P </it>= 0.277) but still remained significant for E-selectin (<it>P </it>= 0.011).</p> <p>Conclusions</p> <p>Ameliorated vitamin D status was accompanied by improved glycemic status, lipid profile and endothelial biomarkers in T2D subjects. Our findings suggest both direct and indirect ameliorating effects of vitamin D on the endothelial biomarkers.</p> <p>Trial registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01236846">NCT01236846</a></p
MCP-1 and CCR2 gene variants in oral squamous cell carcinoma
AIM: We aimed to investigate a possible association of the MCP-1 and CCR2 polymorphisms with the risk of developing oral squamous cell carcinoma (OSCC)
Oral cancer in young people: 10 years retrospective
Oral cancer in young people: 10
years retrospectiveObjectives:Oral cancer is the sixth
most common of cancers worldwide. In last two dec-ades there were many reports
emerging about young people having oral cancer, which isknown as having a peak
during the sixth decades. In this study we aimed to evaluate theyoung people
having oral cancer about etiologic factors.Methods:The data was retrospectively
collected from the archives at Istanbul University,Oncology Institute,
Radiation Oncology Department. 51 patients (19 female, 32 male)who were treated
for oral cancer between years 2005-2015 and aged between 18 and 45were
reviewed.Statistical data was evaluated with IBM 22.0 programme and statistical
significance wastaken as P<0.05.Results:The most common location was
the tongue 27.5% followed by the hard palate15.7% and the base of tongue 13.7%.
In terms of etiologic factors smoking, alcohol, fam-ily history of cancer were
investigated. Smoking was found significantly higher in males(P=0.0001) but not
statistically significant between age groups. Alcohol consumptionwas also found
significantly higher in males (P=0.003) but not significant between agegroups.
Family history of cancer results were similar between groups. Nodal
metastasisresults between age groups found statistically significant.Higher
aged group had more nodal metastasis (P=0.05). Histologic grading was alsofound
statistically significant in comparison of age groups. The higher aged group
hadmore poor differentiation than younger aged group (P=0.032).Conclusion:The risk factors we
evaluated in this study have similar results with higherage groups. In the
limitations of this study we could not compare HPV infection anddietary
factors. However further investigations in larger groups, possibly
prospectivelyconducted, could shed more light on risk factors of younger people
having oral cancer.
Relevance:Major avoidable
risk factors for oral cancer seems to be similar whicheverage group we concern.
More efforts both by clinicians and governments are needed, espe-cially to
prevent the use of tobacco products