Nuevo Santander The Unrealized Archaeological Potential of a “Civilian” Province in Northern New Spain

In 1746 the Viceroy of New Spain called for the founding of a new province to be located between the Rio Grande and the Nueces River. Between 1748-1755 two dozen civilian communities of farmers and ranchers were established by the province’s founder José de Escandón. Many towns were founded along the banks of the Rio Grande where there was access to water and lands for agriculture and grazing. Each town served as the administrative, economic, and ecclesiastical hub for surrounding land grants and ranches. Were it not for the work of W. Eugene George, Mindy Bonine, and Mary Jo Galindo, our knowledge of the architectural and archaeological history of this region would be woefully incomplete. In this presentation the CHAPS Program team draws on the work of these pioneers and continuing original research concerning the surviving archaeological and architectural record of the Lower Rio Grande Valley

Etiology of autistic features: the persisting neurotoxic effects of propionic acid

BACKGROUND: Recent clinical observations suggest that certain gut and dietary factors may transiently worsen symptoms in autism. Propionic acid (PA) is a short chain fatty acid and an important intermediate of cellular metabolism. Although PA has several beneficial biological effects, its accumulation is neurotoxic. METHODS: Two groups of young Western albino male rats weighing about 45 to 60 grams (approximately 21 days old) were used in the present study. The first group consisted of oral buffered PA-treated rats that were given a neurotoxic dose of 250 mg/kg body weight/day for three days, n = eight; the second group of rats were given only phosphate buffered saline and used as a control. Biochemical parameters representing oxidative stress, energy metabolism, neuroinflammation, neurotransmission, and apoptosis were investigated in brain homogenates of both groups. RESULTS: Biochemical analyses of brain homogenates from PA-treated rats showed an increase in oxidative stress markers (for example, lipid peroxidation), coupled with a decrease in glutathione (GSH) and glutathione peroxidase (GPX) and catalase activities. Impaired energy metabolism was ascertained through the decrease of lactate dehydrogenase and activation of creatine kinase (CK). Elevated IL-6, TNFα, IFNγ and heat shock protein 70 (HSP70) confirmed the neuroinflammatory effect of PA. Moreover, elevation of caspase3 and DNA fragmentation proved the pro-apoptotic and neurotoxic effect of PA to rat pups CONCLUSION: By comparing the results obtained with those from animal models of autism or with clinical data on the biochemical profile of autistic patients, this study showed that the neurotoxicity of PA as an environmental factor could play a central role in the etiology of autistic biochemical features

From a Tabula Rasa to the Governor’s Award for Historic Preservation

Prior to 2009, South Texas was essentially an archaeological tabula rasa, largely unknown in the academic, public, or grey literature due to its location far from research universities, the state historic preservation office, and cultural resource management firms. Here, we relate how a consortium of anthropologists and archaeologists, biologists, historians, geologists, and geoarchaeologists have embraced a locally focused, place-based STEAM research approach to tell the story of a largely unknown region of the United States and make it accessible to K–17 educators,1 the public, and scholars with bilingual maps, books, exhibits, films, traveling trunks, and scholarly publications. The efforts of the Community Historical Archaeology Project with Schools Program at the University of Texas Rio Grande Valley have been recognized locally, nationally, and internationally

Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia

<p>Abstract</p> <p>Objectives</p> <p>Autism is a developmental disorder characterized by social and emotional deficits, language impairments and stereotyped behaviors that manifest in early postnatal life. This study aims to clarify the relationship amongst absolute and relative concentrations of K⁺, Na⁺, Ca²⁺, Mg²⁺and/or proinflammatory and proapoptotic biomarkers.</p> <p>Materials and methods</p> <p>Na⁺, K⁺, Ca²⁺, Mg²⁺, Na⁺/K⁺, Ca²⁺/Mg²⁺together with IL6, TNFα as proinflammatory cytokines and caspase3 as proapoptotic biomarker were determined in plasma of 25 Saudi autistic male patients and compared to 16 age and gender matching control samples.</p> <p>Results</p> <p>The obtained data recorded that Saudi autistic patients have a remarkable lower plasma caspase3, IL6, TNFα, Ca²⁺and a significantly higher K⁺compared to age and gender matching controls. On the other hand both Mg²⁺and Na⁺were non-significantly altered in autistic patients. Pearson correlations revealed that plasma concentrations of the measured cytokines and caspase-3 were positively correlated with Ca²⁺and Ca²⁺/K⁺ratio. Reciever Operating Characteristics (ROC) analysis proved that the measured parameters recorded satisfactory levels of specificity and sensitivity.</p> <p>Conclusion</p> <p>Alteration of the selected measured ions confirms that oxidative stress and defective mitochondrial energy production could be contributed in the pathogenesis of autism. Moreover, it highlights the relationship between the measured ions, IL6, TNFα and caspase3 as a set of signalling pathways that might have a role in generating this increasingly prevalent disorder. The role of ions in the possible proinflammation and proapoptic mechanisms of autistics' brains were hypothesized and explained.</p

Plasma fatty acids as diagnostic markers in autistic patients from Saudi Arabia

<p>Abstract</p> <p>Backgrounds</p> <p>Autism is a family of developmental disorders of unknown origin. The disorder is characterized by behavioral, developmental, neuropathological and sensory abnormalities, and is usually diagnosed between the ages of 2 and 10 with peak prevalence rates observed in children aged 5-8 years. Recently, there has been heightened interest in the role of plasma free fatty acids (FA) in the pathology of neurological disorders. The aim of this study is to compare plasma fatty acid profiles of Saudi autistic patients with those of age-matching control subjects in an attempt to clarify the role of FA in the etiology of autism.</p> <p>Methods</p> <p>26 autistic patients together with 26-age-matching controls were enrolled in the present study. Methyl esters of FA were extracted with hexane, and the fatty acid composition of the extract was analyzed on a gas chromatography.</p> <p>Results</p> <p>The obtained data proved that fatty acids are altered in the plasma of autistic patients, specifically showing an increase in most of the saturated fatty acids except for propionic acid, and a decrease in most of polyunsaturated fatty acids. The altered fatty acid profile was discussed in relation to oxidative stress, mitochondrial dysfunction and the high lead (Pb) concentration previously reported in Saudi autistic patients. Statistical analysis of the obtained data shows that most of the measured fatty acids were significantly different in autistic patients compared to age -matching controls.</p> <p>Conclusions</p> <p>Receiver Operating Characteristic (ROC) curve analysis shows satisfactory values of area under the curve (AUC) which could reflect the high degree of specificity and sensitivity of the altered fatty acids as biomarkers in autistic patients from Saudi Arabia.</p

Native American Peoples of South Texas

Sponsored by Summerfield G. Roberts Grant.https://scholarworks.utrgv.edu/chapspublications/1018/thumbnail.jp

A multidimensional program including standing exercises, health education, and telephone support to reduce sedentary behavior in frail older adults:Randomized clinical trial

Objectives: The primary aim of this study was to evaluate the effect of a multidimensional program including home-based standing exercises, health education, and telephone support for the reduction of sedentary behavior in community-dwelling frail older adults. The secondary aim of this study was to evaluate the safety and adherence of the program. Study design: A single-blind, randomized controlled trial. Methods: A total of 43 frail older adults were randomly assigned to the intervention and control groups. The intervention consisted of combined strategies including home-based standing exercises, health education, and telephone support for 16 weeks for frail older adults. The control group received orientation regarding the harmful effects of a sedentary lifestyle. Sedentary behavior was evaluated by total sedentary time, accumulated sedentary time in bouts of at least 10 min, and by the break in sedentary time, measured by an accelerometer used for at least 600 min/day for 4 days. Safety was assessed by self-reporting of possible adverse events. Adherence was assessed based on the number of days in which standing exercises were performed by the participants. Repeated measures ANOVA and Tukeys post hoc test were used to analyze the collected data. Results: The intervention group reduced the sedentary time by 30 min/day (p= 0.048), but without significant maintenance after 30 days of the program. Of the total number of participants, 82% (n = 14) of the intervention group participants showed more than 70% adherence to the program. The main adverse effects faced by the intervention group participants were tiredness (53%; n = 9) and lower limb pain (47%; n = 8). Conclusions: The multidimensional program reduced sedentary behavior, was safe, and showed satisfactory adherence in frail older adults

From Porciones to Colonias: The Power of Place and Community-Based Learning in K-12 Education - A Case Study From the Lower Rio Grande Valley of Texas

From Porciones to Colonias: The Power of Place- and Community-Based Learning in K-12 Education redefines culturally relevant learning in today’s diverse classroom. By integrating an interdisciplinary approach including: anthropology, archeology, biology, geology, and history the CHAPS Program presents an effective method in supporting teachers of the Rio Grande Valley in creating culturally relevant curriculum, while meeting the demands of state and federal mandates. Sponsored by The National Endowment for the Humanities.https://scholarworks.utrgv.edu/chapspublications/1010/thumbnail.jp

Challenges and experiences in linking community level reported out-of-pocket health expenditures to health provider recorded health expenditures: experience from the iHOPE project in Northern Ghana

Out of pocket health payment (OOPs) has been identified by the System of Health Accounts (SHA) as the largest source of health care financing in most low and middle-income countries. This means that most low and middle-income countries will rely on user fees and co-payments to generate revenue, rationalize the use of services, contain health systems costs or improve health system efficiency and service quality. However, the accurate measurement of OOPs has been challenged by several limitations which are attributed to both sampling and non-sampling errors when OOPs are estimated from household surveys, the primary source of information in LICs and LMICs. The incorrect measurement of OOP health payments can undermine the credibility of current health spending estimates, an otherwise important indicator for tracking UHC, hence there is the need to address these limitations and improve the measurement of OOPs. In an attempt to improve the measurement of OOPs in surveys, the INDEPTH-Network Household out-of-pocket expenditure project (iHOPE) developed new modules on household health utilization and expenditure by repurposing the existing Ghana Living Standards Survey instrument and validating these new tools with a 'gold standard' (provider data) with the aim of proposing alternative approaches capable of producing reliable data for estimating OOPs in the context of National Health Accounts and for the purpose of monitoring financial protection in health. This paper reports on the challenges and opportunities in using and linking household reported out-of-pocket health expenditures to their corresponding provider records for the purpose of validating household reported out-of-pocket health expenditure in the iHOPE project