7 research outputs found
Clinical course and treatment results of breast cancer patients with ten or more positive axillary nodes
Two-hundred and fifty-nine women with operable breast cancer, having
more than 10 involved nodes without a distant metastasis, were treated
with radical, modified radical or partial mastectomy with complete
axillary dissection. Survival at 5 years was 63% and at 7 years 54%.
Fifty-six per cent and 52% were disease free 5 and 7 years after
initial therapy. Postmenopausal women had an overall survival rate of
64% and disease free survival rate of 61% while premenopausal women
had an overall survival of 58% and disease free survival of 52%.
Survival and disease free survival rate for those with 10-20 positive
nodes were 65% and 69% respectively, while for those with more than 20
positive nodes the rates were 49% and 52% respectively; a
statistically better survival in the 2nd group. Although the
observational time of patients having adjuvant CEF is short, a better
survival rate and disease free survival rate is possible in women
treated with CEF. (C) 2000 Harcourt Publishers Ltd
Neoangiogenesis in invasive and preinvasive breast cancer. Relationship with calcitonin gene related peptide (CGRP) immunohistochemistry and mammographically detected microcalcifications (MC). Influence in Tcc-99m (V)DMSA and Tc-99m MIBI tumour uptake
Does pregnancy-associated breast cancer imply a worse prognosis? a matched case-case study
Background: Significant controversy exists in the literature regarding the role of pregnancy in the prognosis of breast cancer. We designed a matched case-case study, matching pregnancy-associated breast cancer (PABC) cases with breast cancer cases for stage, age, and year of diagnosis. Patients and Methods: 39 consecutive cases of PABC were matched with 39 premenopausal cases of breast cancer. Univariate and multivariate survival analyses followed by adjustment for stage, grade, estrogen receptor status, and age at diagnosis, were performed. Results: Regarding overall survival (OS), univariate analysis pointed to longer OS in non-PABC cases vs. PABC cases. Accordingly, a more advanced stage predicted shorter survival. In the multivariate analysis, the independent aggravating effect mediated by pregnancy persisted. Interestingly, a post hoc nested analysis within PABC cases indicated that the 3rd trimester pointed to shorter OS. The aforementioned results on OS were also replicated during the examination of relapse-free survival. Conclusion: Implementing a matched case-case design, the present study points to pregnancy as a poor prognostic factor for breast cancer. © 2013 S. Karger GmbH, Freiburg