'Nowhere to be found’: disabled refugees and asylum seekers within the Australian resettlement landscape

Australia has long placed restrictions on the immigration of people with disabilities. While recent civil society mobilisation has forced some shift in policy, it is far from clear whether this will result in people with disabilities being accepted as immigrants. The issue is complicated further for people defined as ‘refugees’ and ‘asylum seekers’ who have encountered the migration restrictions on disability. As a result of this policy landscape, there is limited rigorous research that seeks to understand the social inclusion and participation of disabled refugees and asylum seekers within the resettlement process. An extensive review reveals that refugees and asylum seekers with disabilities remain largely absent from both resettlement literature and disability research. This paper summarises the limited available research in the area around the following themes: processes of offshore migration and the way that disability is assessed under Australia’s refugee legislation; the uncertainty of the prevalence of disability within refugee and asylum seeker communities; the provision of resettlement services, both mainstream and disability-specific, through the transitional period and beyond; and the invisibility of asylum seekers with disabilities in Australia’s immigration detention centres, community-based arrangements and offshore processing centres. To conclude, the paper outlines implications for further research, policy and practice in the Australian context

32-core dense SDM unidirectional transmission of PDM-16QAM signals over 1600 km using crosstalk-managed single-mode heterogeneous multicore transmission line

We demonstrate 32-core dense space-division multiplexed (DSDM) unidirectional transmission of PDM-16QAM 20-WDM signals over 1644.8km employing a low-crosstalk single-mode heterogeneous 32-core fiber in a partial recirculating-loop system

Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells

Microsomal triglyceride transfer protein (MTP), an endoplasmic reticulum (ER) chaperone that loads lipids onto apolipoprotein B, also regulates CD1d presentation of glycolipid antigens in the liver and intestine. We show MTP RNA and protein in antigen-presenting cells (APCs) by reverse transcription–polymerase chain reaction and by immunoblotting of mouse liver mononuclear cells and mouse and human B cell lines. Functional MTP, demonstrated by specific triglyceride transfer activity, is present in both mouse splenocytes and a CD1d-positive mouse NKT hybridoma. In a novel in vitro transfer assay, purified MTP directly transfers phospholipids, but not triglycerides, to recombinant CD1d. Chemical inhibition of MTP lipid transfer does not affect major histocompatibility complex class II presentation of ovalbumin, but considerably reduces CD1d-mediated presentation of α-galactosylceramide (α-galcer) and endogenous antigens in mouse splenic and bone marrow–derived dendritic cells (DCs), as well as in human APC lines and monocyte-derived DCs. Silencing MTP expression in the human monocyte line U937 affects CD1d function, as shown by diminished presentation of α-galcer. We propose that MTP acts upstream of the saposins and functions as an ER chaperone by loading endogenous lipids onto nascent CD1d. Furthermore, our studies suggest that a small molecule inhibitor could be used to modulate the activity of NKT cells