Beneficial effects of rolipram, a phosphodiesterase 4 specific inhibitor, on testicular torsion-detorsion injury in rats

PubMedID: 29773452Introduction: The aim of the study is to investigate the effect of Rolipram, a selective phosphodiesterase 4 inhibitor, on testicular torsion – detorsion injury. Methods: Sixty young male rats were divided into five groups. In each group, the right testes of six rats were removed four hours after detorsion for biochemical analysis, and the right testes of the remaining six rats were removed 24 h after detorsion for pathological analysis. In group 1 (sham-operated) right orchiectomy was performed without torsion, and right testes were sent to the laboratory for biochemical and pathologic analyses. In group 2 (control) torsion was applied to the right testes for 60 min, and detorsion was performed without the administration of Rolipram. In group 3 torsion was applied to the right testes for 60 min. 1 mg/kg Rolipram was administered 30 min before detorsion. In group 4 torsion was applied to the right testes for 60 min, and 1 mg/kg Rolipram was administered during detorsion. In group 5 torsion was applied to the right testes for 60 min. 1 mg/kg Rolipram was administered 30 min after detorsion. The malondialdehyde and nitric oxide levels were determined. The rates of necrosis and apoptosis were evaluated by histopathological examination. Results: The level of malondialdehyde was higher in the torsioned groups (Group 2, 3, 4, 5) than that in group 1 (p = 0.004). There was no statistically significant difference between the groups regarding the level of nitric oxide (p = 0.182). Apoptosis was higher in groups 2, 3 and 4 than in group 1; however, apoptosis was similar in group 1 and group 5 (p = 0.122). The level of necrosis in group 1 was similar to that in groups 4 and 5 (p = 0.194 and p = 0.847, respectively). Conclusion: We suggest that the administration of Rolipram can decrease the rate of necrosis and apoptosis in testicular ischaemia-reperfusion injury. © 2018 Elsevier Inc

Impact of Carbonization on the Combustion and Gasification Reactivities of Olive Wastes

7th Global Conference on Global Warming (GCGW) -- JUN 24-28, 2018 -- Izmir, TURKEYDuman Tac, Gozde/0000-0002-9427-8235WOS: 000587895700018As an alternative to biomass, biochar is known as a promising candidate to replace or co-process with coal as solid fuel. in this study, biochars were obtained from pyrolysis of olive tree pruning (OP) at different temperatures and duration in order to investigate their possible use in combustion and gasification processes alone or with lignite. Steam gasification experiments of raw biomass, biochars and their blends with lignite were conducted in two-stage reactor at 850 degrees C to produce hydrogen-rich gas. the combustion behavior of fuels was investigated using thermogravimetric analyzer. the temperature was more effective than duration on the yield and properties of biochar. Biochars obtained above 350 degrees C had more aromatic structure with higher fixed carbon content. Gasification of biochar wasmore efficient than that of biomass, due to its high carbon content, homogeneous properties, and minimized tar formation. Hydrogen yield increased with the increase in the potassium and fixed carbon contents of biochars. Slagging and fouling indices of biochars indicated the tendency of slagging and fouling during their combustion alone. For the blends containing OP and biochars produced at low temperatures, antisynergistic effect was observed, lowering the combustion reactivity. in contrast, no interaction was found for the blend containing high-temperature biochar.TUBITAK under the Eranet-Med2 Programme of the EU (Project Acronym: MEDWASTE)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [117M570]The financial supports from TUBITAK (Project Contract No: 117M570) under the Eranet-Med2 Programme of the EU (Project Acronym: MEDWASTE)