Determining the possible demand according to the sizes in ready made clothing ındustry: A model application and comparison

İşletmeler, zorlaşan rekabet şartları altında ayakta kalabilmek ve rekabet edebilmek için karşılaştıkları çeşitli sorunların çözümüne yönelik etkin kararlar almak zorundadırlar. Geleceğe yönelik verilecek kararlar işletmeler için belirsizlik içerdiğinden, bu kararların alınmasında çeşitli tahminler yapılmalıdır. Bunlardan biri de talep tahminleridir. İşletmelerin ürünlerine olan talebi tahmin etmeleri, belirlenecek pazarlama stratejileri açısından önemli bir veri niteliği taşımaktadır. Bu araştırma da hazır giyim işletmelerinde hangi beden numarasında ne kadar talep oluşacağını belirlemede uygulanan yöntemlerden elde edilen sonuçlarla, gerçekleşen talebi karşılaştırarak üretilecek beden numaralarının miktarının belirlenmesinde en doğru sonucu verebilecek talep tahmin yöntemini belirlemek amaçlanmıştır. Araştırma verileri büyük ölçekli bir hazır giyim işletmesinden toplanmıştır. Bu veriler 2007-2012 yılları arasında satılan ürünlerin beden numaralarından oluşmaktadır. İşletmeden alınan veriler üzerine talep tahmin yöntemlerinden aritmetik ortalama, hareketli ortalama ve ağırlıklı hareketli ortalama yöntemleri uygulanmıştır. Bu uygulama sonucunda hesaplanan sonuçlar ile gerçekleşen talep karşılaştırılmıştır. Bu araştırma hazır giyim işletmelerinin gelecekteki beden numaralarına göre oluşacak talebi belirlemelerine, üretim planlarının daha isabetli olmasına ve satışlarına katkı sağlayacaktır.Business operations have to take effective decisions to the various problems they could face in order to stand and compete under the conditions which are getting harder day by day. Due to the decisions for the future plans of the corporations include uncertainty, diverse predictions should be made to avoid possible problems. One of these predictions is demand forecasting. To predict the possible demand is a significant data for businesses to determine their future marketing strategy. This research is made to identify the best type of demand forecasting to determine the quantity of goods to be produced by evaluating the possible demand for each size in ready-made clothing businesses and then comparing them to the real demand numbers. Research data has been collected from a large-scale ready-made clothing enterprise. This data consists of all the sizes of clothes which were sold through 2007 to 2012. According to these values various demand forecasting methods were implemented such as arithmetic mean, moving average, and weighted moving average. After all, evaluated data from demand forecasting compared to real demand. This research will contribute to enterprises in order to determine their possible future demand for each size, to do production planning more precisely and their sales numbers

Does myeloma genetic have an effect on stem cell mobilization?

Background: Autologous stem cell transplantation (ASCT) after induction treatment is the standard of care. Our understanding of myeloma genetics has been very limited and its effect to stem cell mobilization is not widely investigated. We aimed to investigate the effect of genetic abnormalities on stem cell mobilization in myeloma. Methods: The data of 150 MM patients who underwent stem cell mobilization at our center between 2009–2020 were included and analyzed retrospectively. Pre-treatment bone marrow cytogenetics and fluorescence in situ hybridization tests were performed for each patient. Results: Groups were divided into two as patients with normal cytogenetic and abnormal cytogenetic. No difference observed between groups regarding age, gender and ECOG (p = 0.4; p = 0.2; p = 0.3). Groups were similar concerning myeloma characteristics, received treatment and treatment response. Median CD34+ cells/kg harvested was 444(2−11.29) in normal cytogenetic group whereas it was 4,8(2.4−8.6) in abnormal cytogenetic group(p = 0.2). Optimal CD34+ cells level achievement was 73 (67 %) in normal cytogenetic group while it was 25(71.4 %) in abnormal cytogenetic group(p = 0.6). Neutrophil and platelet engraftment durations were similar among cytogenetic groups (p = 0.7; p = 0.9). R-ISS based groups were also did not differ regarding harvested CD34+ cells and achievement optimal CD34 level (p = 0.79, p = 0.74). Engraftment durations for neutrophil and platelet were comparable between R-ISS based groups (p = 0.59, p = 0.65) Conclusions: Here we were not able to find any impact of genetic abnormalities on stem cell mobilization in myeloma patients. Expanded studies can aid to identify the effect of particular genetic anomalies on the stem cell mobilization

Old is bad? The effect of age on peripheral stem cell mobilization and transplantation outcomes

Introduction: Allogeneic stem cell transplantation (Allo-SCT) is a well-established treatment option for hematological malignancies. With the introduction of reduced-intensity conditioning regimens (RIC) and better supportive measures the elderly are able to receive Allo-SCT. A considerable number of patients are elderly, and often their HLA matched sibling donor is elderly, moreover. Here, we aim to explore the effect of donors’ age on stem cell harvesting, engraftment duration after Allo-SCT, and product quality. Method: Sixty-one healthy allogeneic stem cell donors aged 50 years and older who underwent stem cell mobilization at our center between 2009–2019 were enrolled for the study. All donors received 4–5 days of G-CSF, mostly filgrastim or lenograstim and their biosimilar equivalents were given subcutaneously as a total dose of 10 mcg/kg/day. Groups were separated into three groups as aged 50–54 group A, 55–59 group B, aged 60 and older group C. Results: Pre-apheresis peripheral blood CD34+ count was similar all groups (p = 0.2). One day apheresis was sufficient for 72.7 % of group A, 27.3 % for group B and 47.1 % for group C (p = 0.02). Total harvested CD34+ cells were comparable among groups (p = 0.5). Conclusion: Adequate stem cell harvest in older donors is feasible. Older donors may require more than one apheresis procedure and generally procedure was well tolerated. When assessing donors, age should represent less significance