2 research outputs found

    Postpartum Thyroiditis

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    DergiPark: 1020940tmsjPostpartum thyroiditis is an autoimmune disease of the thyroid gland seen in approximately 8% of women in the postpartum period. Postpartum thyroiditis is a triphasic disease consisting of hyperthyroid, hypothyroid, and euthyroid phases. The pathogenesis of postpartum thyroiditis is not known exactly. However, there are various mechanisms related to pathogenesis. One of these is related to the fetal cell/DNA circulating in the maternal blood to settle in the thyroid gland and the maternal immune system to develop an autoimmune reaction against the thyroid gland in the postpartum period. During pregnancy, fetal cells settle in the thyroid gland and no reaction occurs due to pregnancy-related immunosuppression. Postpartum thyroiditis occurs because immunosuppression disap- pears in the postpartum period. The method of examining fetal cell/DNA in maternal blood during pregnancy is a non-invasive prenatal test. The non-invasive prenatal testing is a screening test used to detect chromosomal anomalies and some other chromosomal defects. However, there is to our knowledge, not enough studies in the literature directly investigating the relationship between the number of fetal cells/DNA in maternal blood and the development of postpartum thyroiditis. Having reviewed the literature around this topic it can be assumed that there can be a difference in the level of damage in the thyroid gland in the postpartum period, depending on the level of difference in the number of fetal cells in the thyroid gland. In addition, future studies will pave the way for studies on the relationship between autoimmune diseases occurring in the post-pregnancy period and the number of fetal DNA/cells in maternal blood during preg- nancy. Therefore, an early diagnosis of pregnancy-related autoimmune diseases will be enabled

    Caenorhabditis Elegans and Angiogenesis

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    DergiPark: 541687tmsjAbstract: Angiogenesis is sprouting of new capillaries from already existing ones. It is a dynamic process that can be seen in every phase of human life. It is among the dynamic mechanisms of both physiological and pathological processes. Vascular endothelial growth factor is one of the many molecules that play a role in angiogenesis. Vascular endothelial growth factor is released specifically to the endothelium. It regulates mitogenesis, vascular tone, vascular permeability and vasodilatation in the vascular endothelium. Caenorhabditis elegans is a nematode used to detect and screen the developmental processes and genetic mutations. It is appropriate to study at the organism level to isolate cells and to demonstrate intercellular interactions in vivo. Polyvinyl fluoride-1 is a molecule that plays a role in the neural development of Caenorhabditis elegans. In addition, the polyvinyl fluoride-1 molecule is told to be effective in angiogenesis. Studies have shown that polyvinyl fluoride-1 binds to vascular endothelial growth factor receptor-1 and vascular endothelial growth factor receptor-2, but not to vascular endothelial growth factor receptor-3 and platelete derivated growth factor receptor ?. In the research of human umbilical vein endothelial lines, it was observed that polyvinyl fluoride-1 induced angiogenesis and vascular tube formation. These results suggest that Caenorhabditis elegans may have a very important role in vascular endothelial growth factor studies. Caenorhabditis elegans model is used in many scientific areas such as aging, nervous system and genetic changes. However, only a few laboratories around the world studied the Caenorhabditis elegans angiogenesis model. Besides, this model is not currently used in Turkey. This provides a great advantage in terms of the utilization of this model in angiogenesi
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