Imaging of Primitive Neuroectodermal Tumor (PNET) by Technetium-99m Tetrofosmin

Purpose. Tc-99m tetrofosmin launched for myocardial studies has recently also shown a good detectability for several tumors. Data on PNET imaging by Tc-99m tetrofosmin are not yet available

Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli

Genome-wide simultaneous measurements of pre-mRNA and mRNA expression reveal unexpected time-dependent transcript production and degradation profiles in response to external stimulus, as well as a striking lack of concordance between mRNA abundance and transcript production profiles

Client-server optimization for multimedia document exchange

The success of the World Wide Web is boosting the development of multimedia database systems and their integration into the internet. For the documents stored and exchanged in the Web there is a variety of multimedia data formats differing in aspects such as resolution, sampling rate, and compression. Furthermore there is a large heterogeneity of Web browsers, the data formats they support, and their network access. Thus storage servers have to store and proxy servers have to transfer many different formats. However, the data formats are not independent from each other but interrelated by conversion tools. There is a large number of alternatives for storage and proxy servers to store some formats or to transfer them via the network and to compute the remaining ones by applying conversion tools. To determine an optimal choice is a nontrivial optimization problem and is subject to changes of the parameters such as query profile, available disk storage, and network bandwidth. We examine the outlined optimization problem in the context of object-oriented databases and illustrate our approach by a practical application

Client-Server Optimization for Multimedia Document Exchange

The success of the World Wide Web is boosting the development of multimedia database systems and their integration into the internet. For the documents stored and exchanged in the Web there are many multimedia data formats di#ering in aspects such as resolution, sampling rate, and compression. Furthermore there is a large variety of Web browsers, the data formats they support, and their network access. Thus storage servers have to store and proxy servers have to transfer many di#erent formats. However, the data formats are not independent from each other but interrelated by conversion tools. Thereisalarge number of alternatives for storage and proxy servers to store some formats or to transfer them via the network and to compute the remaining ones by applying conversion tools. To determine an optimal choice is a nontrivial optimization problem and is subject to changes of the parameters such as query pro#le, available disk storage, and network bandwidth. We examine the outlined optim..

Subtyping by constraints in object-oriented databases

For many object-oriented database applications taxonomies with a setinclusion semantics among the type extents are essential. In practical cases, however, common object-oriented modeling techniques often do not result in taxonomies as they ignore application specific constraints. We will elaborate that especially in domains like CAD or similar engineering environments integrity constraints on type attributes have a deep impact on the resulting hierarchy. We argue that subtyping by constraints may be superior to other object-oriented alternatives like subtyping for generalization or nearly-flat hierarchies. Subtyping by constraints achieves a logical set-inclusion hierarchy, and in addition enables a larger amount of semantically correct substitutability. This can even be improved by a novel framework of automatic method adaptation for enhanced substitutability

Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy

AbstractThe EGF-receptor is frequently mutated in a large variety of tumors. Here we review the most frequent mutations and conclude that they commonly enhance the intrinsic tyrosine kinase activity, or they represent loss-of-function of suppressive regulatory domains. Interestingly, the constitutive activity of mutant receptors translates to downstream pathways, which are subtly different from those stimulated by the wild-type receptor. Cancer drugs intercepting EGFR signaling have already entered clinical application. Both kinase inhibitors specific to EGFR, and monoclonal antibodies to the receptor are described, along with experimental approaches targeting the HSP90 chaperone. Deeper understanding of signaling pathways downstream to mutant receptors will likely improve the outcome of current EGFR-targeted therapies, as well as help develop new drugs and combinations