Management of cervical cancer during pregnancy

WOS: 000373739200023PubMed ID: 26467977Cervical cancer (CC) is the most common gynaecological cancer during pregnancy. The rarity of the disease and lack of randomised control studies have prevented the establishment of treatment guidelines. The management of CC mainly follows the guidelines for the non-pregnant disease state, expert opinions and limited case reports. Although the management of CC diagnosed during pregnancy appears to be a significant dilemma for the patients and specialists, the prognosis of CC is not influenced by pregnancy. The treatment decision should be made collaboratively with a multidisciplinary team consisting of an obstetrician, gynaecologist, oncologist and paediatrician. The concerns of the patient should be taken into account

Effect of cartilage thickness mismatch in osteochondral grafting from knee to talus on articular contact pressures: A finite element analysis

Objectives: The aim of this study was to investigate the effect of cartilage thickness mismatch on tibiotalar articular contact pressure in osteochondral grafting from femoral condyles to medial talar dome using a finite element analysis (FEA). Materials and methods: Flush-implanted osteochondral grafting was performed on the talar centromedial aspect of the dome using osteochondral plugs with two different cartilage thicknesses. One of the plugs had an equal cartilage thickness with the recipient talar cartilage and the second plug had a thicker cartilage representing a plug harvested from the knee. The ankle joint was loaded during a single-leg stance phase of gait. Tibiotalar contact pressure, frictional stress, equivalent stress (von Mises values), and deformation were analyzed. Results: In both osteochondral grafting simulations, tibiotalar contact pressure, frictional stress, equivalent stress (von Mises values) on both tibial and talar cartilage surfaces were restored to near-normal values. Conclusion: Cartilage thickness mismatch does not significantly change the tibiotalar contact biomechanics, when the graft is inserted flush with the talar cartilage surface

Epidemiology, anticoagulant treatment and risk of thromboembolism in patients with valvular atrial fibrillation: Results from Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER)

Background: The aim of this study was to perform a multicenter, prospective investigation regarding the epidemiology, the current effectiveness of therapeutic anticoagulation, and the risk of thromboembolism in patients with valvular atrial fibrillation (AF) based on the records of the Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER) study. Methods: Patients were selected from a total of 2,242 consecutive admissions that presented with AF diagnosed via electrocardiogram. Those diagnosed with non-valvular AF were excluded from the AFTER study population, which left 497 patients with valvular AF for analysis. Results: The etiology of valvular AF in patients was either attributed to rheumatic mitral valve stenosis (n = 217) or possessing a prosthetic heart valve (n = 280). Out of all the patients with valvular AF, 83.1% were taking warfarin for anticoagulation. Only 36.1% demonstrated a therapeutic international normalized ratio (INR), and among those patients it was found that 19.1% exhibited a labile INR. Multivariate analysis revealed that age was the only independent predictor of thromboembolic events in patients with valvular AF. Conclusions: Many valvular AF patients are not maintained at therapeutic INR levels, which poses a threat to patient health as they age and are at greater risk for thromboembolism

Boyuna-eğimli bir yatay eksenli rüzgâr türbini kanadının had çalışması

WOS:000413657900014Wind energy is being used to generate electricity in many countries all over the world and still the contribution of wind energy to electricity supply increases every day. Researchers work on innovative solutions to increase the efficiency and decrease the cost of wind turbine components, especially those of blades. Various blade designs for different operation conditions are presented in the literature and sweeptwist blades are new type of blades introduced recently. This paper focuses on the numerical investigation of a sweep-twist wind turbine blade using ANSYS-Fluent. NREL Phase VI wind turbine blade is used as the baseline blade and the sweep-twist blade is designed by adding an offset that is 5% of the blade span to the tip. Power output and thrust forces are calculated using the simulation results for both original and sweep blades. In addition, results are compared to the experimental data of original NREL Phase VI blade.Rüzgâr enerjisi elektrik üretmek amacıyla dünyada birçok ülkede kullanılmaktadır ve rüzgâr enerjisinin elektrik üretimine katkısında günden güne yükselmektedir. Araştırmacılar rüzgâr türbini bileşenlerinin – özellikle kanatların - verimlerinin arttırılması ve maliyetlerinin azaltılması için yenilikçi çözümler üzerinde durmaktadırlar. Literatürde çeşitli çalışma koşulları için değişik tasarımlar mevcut olup, eğimli kanatlar bunlardan biridir. Bu çalışmada ANSYS-Fluent programı ile eğimli bir rüzgâr türbini kanadının numerik analizi üstünde durulmuştur. NREL Faz VI rüzgâr türbini kanadı baz alınmış ve eğimli kanadı ise uç kısmına kanat boyunun %5’si kadar eğim verilerek tasarlanmıştır. Güç çıkışları ve itme kuvvetleri simülasyon sonuçlarına göre hesaplanmıştır. Buna ek olarak, sonuçlar NREL Faz VI rüzgâr türbininin deneysel sonuçları ile karşılaştırılmıştır.Scientific Research Project Coordination Unit of Karamanoglu Mehmetbey UniversityThe authors would like to thank to Scientific Research Project Coordination Unit of Karamanoglu Mehmetbey University for the support

Use of Pumped Hydro Energy Storage to Compliment Renewable Energy: A case study for Cumra, Turkey

Energy has become one of the main requirements of human beings today. Different energy supply methods have been developed until today but the limitation of fossil fuels pointed researches to work on renewable energy systems since renewable energy sources are unlimited, clean and sustainable. The dependency of renewable energy sources on the weather and climate was another problem for researchers because of the requirement of firm power. Energy storage systems have been seen as a solution to prevent power fluctuations and supply firm power from energy production systems. The situation is same for Turkey, investments on renewable energy sources increases day by day and this causes Turkey to require energy storage systems to balance the energy in the network. In this paper, bulk energy storage methods, especially pumped hydro energy storage, are examined. A case study is performed to meet the electrical energy demand of irrigation pumps which have huge electrical energy consumption in total and used for irrigation in Alibeyhuyugu, Cumra, Turkey. Simulation and also economic analysis results have been presente

Wind Power Plants for Low Rated Wind Speed Regions: Feasibility Analysis and Simulation of a System

The use of wind power has become an important and growing part of the electrical energy supply in many countries all over the world. Wind turbines are the main components of wind power stations and every single development on these turbines affects the market. Latest developments in wind turbine technologies caused to decrease in costs, thus, besides high-wind-speed regions, low-wind-speed regions are taken into account as a feasible option to generate electricity. The present work investigates the feasibility of a wind power station located in a low rated wind speed region of Turkey providing a general approach for selection of the suitable wind turbine. Economic analysis was performed by calculating the key financial figures such as net present value (NPV), basic payback period (BPP) and the internal rate of return (IRR) for five various options and hourly mean, monthly and seasonal power productions are simulated for the most feasible option using the wind speed measurements in the region. Results show that it is possible to obtain a reasonable capacity factor in low rated wind speed regions with wind turbines that have larger rotors. Although the average wind speed is low in the examined region, a wind power station is still found to be feasible. According to the simulation results, maximum power is produced during the evening hours on a daily basis and during the summer months on a seasonal basis, ensuring power flow usually when maximum power consumption levels are reached. All the data used in this study are based on long-term measurements

Complementarity of wind power and pumped hydro energy storage systems – a case study: meeting the electrical energy demand of rural irrigation pumps of Cumra, Alibeyhuyugu

Energy has been one of the most important components for human beings to have a comfortable life. Much has been discussed about energy production methods since energy is such a remarkable topic. Renewable energy sources have become more popular in recent years because of the limited amount of fossil fuels. However, the dependency of renewable energy sources on the weather and climate, pointed people to search energy storage methods to supply firm power. Especially storing wind energy is one of the most popular topics for researchers. Pumped-hydro, compressed air and battery energy storage systems are the bulk energy storage systems to store wind energy. Pumped-hydro energy storage (PHES) systems are a step ahead among other bulk energy storage methods because they are more efficient and they have higher storage capacities. In this study, we have designed and analyzed a wind-pumped hydro hybrid energy supply system to meet the electrical energy demand of water pumps used for rural irrigation in Cumra, Alibeyhüyüğü and sell the excess energy to the government or local consumers. ALWIN program is used for annual energy generation prediction

Wind Power Plants for Low Rated Wind Speed Regions: Feasibility Analysis and Simulation of a System

The use of wind power has become an important and growing part of the electrical energy supply in many countries all over the world. Wind turbines are the main components of wind power stations and every single development on these turbines affects the market. Latest developments in wind turbine technologies caused to decrease in costs, thus, besides high-wind-speed regions, low-wind-speed regions are taken into account as a feasible option to generate electricity. The present work investigates the feasibility of a wind power station located in a low rated wind speed region of Turkey providing a general approach for selection of the suitable wind turbine. Economic analysis was performed by calculating the key financial figures such as net present value (NPV), basic payback period (BPP) and the internal rate of return (IRR) for five various options and hourly mean, monthly and seasonal power productions are simulated for the most feasible option using the wind speed measurements in the region. Results show that it is possible to obtain a reasonable capacity factor in low rated wind speed regions with wind turbines that have larger rotors. Although the average wind speed is low in the examined region, a wind power station is still found to be feasible. According to the simulation results, maximum power is produced during the evening hours on a daily basis and during the summer months on a seasonal basis, ensuring power flow usually when maximum power consumption levels are reached. All the data used in this study are based on long-term measurements

Analysis on meeting the electric energy demand of an active plant with a wind-hydro hybrid power station in Konya, Turkey: Konya water treatment plant

Hydroelectric plants play an important role in electricity production in Turkey as well as all over the world. However, the increase in the irregularity of flow regimes and the decrease in water ranges of the rivers due to global warming in recent years have revealed that supporter systems are necessary. One alternative solution that could be applied is an integrated system with both hydropower and wind energy. In this study, a system consisting of a hydroelectric power plant (HEPP) and/or wind power plant(s) (WPP) is designed to resolve the energy demand for the Konya water treatment plant, and the results were analyzed. The wind power calculator program and local wind energy measurement data were used to design the WPP. In addition, the water flow rate due to the mean of the elevation difference between the bend of the dam and plant was used to design the HEPP. The electrical energy consumption of the Konya water treatment plant was considered in the design of the WPP and HEPP. The energy production of the WPP and HEPP, the energy demand of the water treatment plant, the monthly and yearly affordability of the energy production were calculated. Additionally, an economic analysis was performed, where the basic payback period was calculated. All the data used in this study are based on longterm measurement