Room temperature Rydberg Single Photon Source

We present an optimal protocol to implement a room temperature Rydberg single photon source within an experimental setup based on micro cells filled with thermal vapor. The optimization of a pulsed four wave mixing scheme allows to double the effective Rydberg blockade radius as compared to a simple Gaussian pulse scheme, releasing some of the constrains on the geometry of the micro cells. The performance of the optimized protocol is improved by about 70% with respect to the standard protocol.Comment: 5 pages, 6 figure

Paliperidone extended-release: does it have a place in antipsychotic therapy?

Paliperidone (9-hydroxy-risperidone), the active metabolite of risperidone, was approved for treating schizophrenia worldwide in 2006 as paliperidone extended-release (PER), and became the first second-generation antipsychotic specifically licensed for treating schizoaffective disorder in 2009. However, at the same time, its comparatively high cost gave rise to concerns about the cost-effectiveness of PER as compared with its precursor, risperidone. This paper reviews the existing knowledge of the pharmacology, kinetics, efficacy, tolerability, and fields of application of PER, and compares PER with risperidone in order to determine whether it has a place in antipsychotic therapy. An independent assessment of all relevant publications on PER published until July 2010 was undertaken. PER has a unique pharmacological profile, including single dosing, predominantly renal excretion, low drug–drug interaction risk, and differs from risperidone in terms of mode of action and pharmacokinetics. High-level evidence suggests that PER is efficacious and safe in schizophrenia, schizoaffective disorder, and acute manic episodes. There is a striking lack of published head-to-head comparisons between PER and risperidone, irrespective of indication. Low-level evidence shows a lower risk for hyperprolactinemia and higher patient satisfaction with PER than with risperidone. PER adds to the still limited arsenal of second-generation antipsychotics. In the absence of direct comparisons with risperidone, it remains difficult to come to a final verdict on the potential additional therapeutic benefits of PER which would justify its substantially higher costs as compared with risperidone. However, in terms of pharmacology, the available evidence cautiously suggests a place for PER in modern antipsychotic therapy

Коммерциализация результатов научно-технической деятельности в Республике Узбекистан

Коммерциализация результатов научных исследований и разработок выступает необходимым условием стратегического развития любой страны, поскольку обеспечивает создание новинок, совершенствование технологии их изготовления с последующим внедрением и эффективной реализацией на внутреннем и зарубежных рынках. В рамках работы были рассмотрены теоретические основы коммерциализация результатов научно-технической деятельности, проведен анализ коммерциализации разработок в Республике Узбекистан, выявлены особенности организации данного процесса и даны рекомендации по его совершенствованию.The commercialization of research and development results is a prerequisite for the strategic development of any country, since it ensures the creation of new products, improvement of their manufacturing technology with subsequent implementation and effective implementation in the domestic and foreign markets. In the framework of the work, the theoretical foundations of the commercialization of the results of scientific and technical activities were considered, an analysis of the commercialization of developments in the Republic of Uzbekistan was carried out, the features of the organization of this process were identified and recommendations for its improvement were given

GHz Rabi flopping to Rydberg states in hot atomic vapor cells

We report on the observation of Rabi oscillations to a Rydberg state on a timescale below one nanosecond in thermal rubidium vapor. We use a bandwidth-limited pulsed excitation and observe up to 6 full Rabi cycles within a pulse duration of ~ 4 ns. We find good agreement between the experiment and numerical simulations based on a surprisingly simple model. This result shows that fully coherent dynamics with Rydberg states can be achieved even in thermal atomic vapor thus suggesting small vapor cells as a platform for room temperature quantum devices. Furthermore the result implies that previous coherent dynamics in single atom Rydberg gates can be accelerated by three orders of magnitude.Comment: 4 pages, 3 figure

Direct neutron capture of 48Ca at kT = 52 keV

The neutron capture cross section of 48Ca was measured relative to the known gold cross section at kT = 52 keV using the fast cyclic activation technique. The experiment was performed at the Van-de-Graaff accelerator, Universitaet Tuebingen. The new experimental result is in good agreement with a calculation using the direct capture model. The 1/v behaviour of the capture cross section at thermonuclear energies is confirmed, and the adopted reaction rate which is based on several previous experimental investigations remains unchanged.Comment: 9 pages (uses Revtex), 2 postscript figures, accepted for publication as Brief Report in Phys. Rev.

A questionnaire-based investigation of the swimming puppy syndrome: 115 dogs

Swimming Puppy Syndrome (SPS) is a benign reversible condition of unknown etiology in multiple dog breeds. Affected dogs show laterally abducted limbs and are unable to stand and walk on their own. The current knowledge of this condition derives from few case reports or small case series. Therefore, the aim of this study was to collect data on the clinical course from a large cohort of dogs with SPS with an online questionnaire supported by video footage. Potential risk factors were compared between 110 litters with SPS and 103 unaffected litters. SPS was reported in 115 dogs from 48 different breeds comprising a wide range of small, middle, and large breeds. Litters with SPS were significantly smaller than unaffected litters. Cesarean sections were reported more frequently in affected litters, but the overall rate of reported birth complications did not differ significantly from unaffected litters. Most puppies were able to stand and walk at a median age of 4.5 weeks (up to 12 weeks) and clinical signs resolved at a median age of six weeks (up to 12 weeks). Puppies from large breeds showed faster recovery than puppies from medium and small breeds. Occasionally, residual deficits were reported and only three dogs failed to recover. A clustering of SPS occurred in closely related litters in four kennels of four different dog breeds (Greater Swiss Mountain Dog, Golden Retriever, Miniature Bull Terrier, Norwich Terrier). The study shows the benign clinical course of SPS in a large cohort of puppies from multiple dog breeds. Potential risk factors including reports on birth complications, size and muscle mass compared to littermates and diet of the dam during pregnany were evaluated and no influence on the occurrence of SPS was identified