22 research outputs found
ALPHA BETA T CELL DEPLETED HLA HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION SINGLE CENTER EXPERIENCE
No full textAspergillus-lateral flow device as a point-of-care test for the diagnosis of invasive fungal infections in patients with leukemia or receiving allogenic stem cell transplantation
No full textChronic granulomatous disease CGD subgroup analysis of patients by FACScan with specific anti human NADPH oxidase components antibodies
No full textHuman NLRP3 inflammasome activation is Nox1-4 independent
No full textThe NLRP3 inflammasome can be activated by pathogen-associated molecular patterns or endogenous danger-associated molecular patterns. The activation of the NLRP3 inflammasome results in proteolytic activation and secretion of cytokines of the interleukin-1 (IL-1) family. The precise mode of activation of the NLRP3 inflammasome is still elusive, but has been postulated to be mediated by reactive oxygen species (ROS) generated by an NADPH oxidase. Using primary cells from chronic granulomatous disease (CGD) patients lacking expression of p22(phox), a protein that is required for the function of Nox1-4, we show that cells lacking NADPH oxidase activity are capable of secreting normal amounts of IL-1beta. Thus, we provide evidence that activation of the NLRP3 inflammasome does not depend on ROS generated from an NADPH oxidase
Immune recovery after transplantation of TCR?ß depletedallografts from haploidentical donors in adult patients
No full textImmune recovery after transplantation of TCR ß depletedallografts from haploidentical donors in adult patients
No full textTcR?ß-depleted haploidentical transplantation results in adult acute leukemia patients.
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