Recording from two neurons: second order stimulus reconstruction from spike trains and population coding

We study the reconstruction of visual stimuli from spike trains, recording simultaneously from the two H1 neurons located in the lobula plate of the fly Chrysomya megacephala. The fly views two types of stimuli, corresponding to rotational and translational displacements. If the reconstructed stimulus is to be represented by a Volterra series and correlations between spikes are to be taken into account, first order expansions are insufficient and we have to go to second order, at least. In this case higher order correlation functions have to be manipulated, whose size may become prohibitively large. We therefore develop a Gaussian-like representation for fourth order correlation functions, which works exceedingly well in the case of the fly. The reconstructions using this Gaussian-like representation are very similar to the reconstructions using the experimental correlation functions. The overall contribution to rotational stimulus reconstruction of the second order kernels - measured by a chi-squared averaged over the whole experiment - is only about 8% of the first order contribution. Yet if we introduce an instant-dependent chi-square to measure the contribution of second order kernels at special events, we observe an up to 100% improvement. As may be expected, for translational stimuli the reconstructions are rather poor. The Gaussian-like representation could be a valuable aid in population coding with large number of neurons

Exact solution of A-D Temperley-Lieb Models

We solve for the spectrum of quantum spin chains based on representations of the Temperley-Lieb algebra associated with the quantum groups {\cal U}_q(X_n } for X_n = A_1,B_n,C_n$and$D_n$. We employ a generalization of the coordinate Bethe-Ansatz developed previously for the deformed biquadratic spin one chain. As expected, all these models have equivalent spectra, i.e. they differ only in the degeneracy of their eigenvalues. This is true for finite length and open boundary conditions. For periodic boundary conditions the spectra of the lower dimensional representations are containded entirely in the higher dimensional ones. The Bethe states are highest weight states of the quantum group, except for some states with energy zero

Quantum spin chains of Temperley-Lieb type: periodic boundary conditions, spectral multiplicities and finite temperature

We determine the spectra of a class of quantum spin chains of Temperley-Lieb type by utilizing the concept of Temperley-Lieb equivalence with the S=1/2 XXZ chain as a reference system. We consider open boundary conditions and in particular periodic boundary conditions. For both types of boundaries the identification with XXZ spectra is performed within isomorphic representations of the underlying Temperley-Lieb algebra. For open boundaries the spectra of these models differ from the spectrum of the associated XXZ chain only in the multiplicities of the eigenvalues. The periodic case is rather different. Here we show how the spectrum is obtained sector-wise from the spectra of globally twisted XXZ chains. As a spin-off, we obtain a compact formula for the degeneracy of the momentum operator eigenvalues. Our representation theoretical results allow for the study of the thermodynamics by establishing a TL-equivalence at finite temperature and finite field.Comment: 29 pages, LaTeX, two references added, redundant figures remove

Generalized Particle Statistics in Two-Dimensions: Examples from the Theory of Free Massive Dirac Field

In the framework of algebraic quantum field theory we analyze the anomalous statistics exhibited by a class of automorphisms of the observable algebra of the two-dimensional free massive Dirac field, constructed by fermionic gauge group methods. The violation of Haag duality, the topological peculiarity of a two-dimensional space-time and the fact that unitary implementers do not lie in the global field algebra account for strange behaviour of statistics, which is no longer an intrinsic property of sectors. Since automorphisms are not inner, we exploit asymptotic abelianness of intertwiners in order to construct a braiding for a suitable $C^*$-tensor subcategory of End($\mathscr{A}$). We define two inequivalent classes of path connected bi-asymptopias, selecting only those sets of nets which yield a true generalized statistics operator.Comment: 24 page

Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00)

Background: The aim of this study was to evaluate the efficacy and tolerability of fulvestrant, an estrogen receptor antagonist, in postmenopausal women with hormone-responsive tumors progressing after aromatase inhibitor (AI) treatment. Patients and methods: This is a phase II, open, multicenter, noncomparative study. Two patient groups were prospectively considered: group A (n = 70) with AI-responsive disease and group B (n = 20) with AI-resistant disease. Fulvestrant 250 mg was administered as intramuscular injection every 28 (±3) days. Results: All patients were pretreated with AI and 84% also with tamoxifen or toremifene; 67% had bone metastases and 45% liver metastases. Fulvestrant administration was well tolerated and yielded a clinical benefit (CB; defined as objective response or stable disease [SD] for ≥24 weeks) in 28% (90% confidence interval [CI] 19% to 39%) of patients in group A and 37% (90% CI 19% to 58%) of patients in group B. Median time to progression (TTP) was 3.6 (95% CI 3.0 to 4.8) months in group A and 3.4 (95% CI 2.5 to 6.7) months in group B. Conclusions: Overall, 30% of patients who had progressed following prior AI treatment gained CB with fulvestrant, thereby delaying indication to start chemotherapy. Prior response to an AI did not appear to be predictive for benefit with fulvestran

Correlation Functions in 2-Dimensional Integrable Quantum Field Theories

In this talk I discuss the form factor approach used to compute correlation functions of integrable models in two dimensions. The Sinh-Gordon model is our basic example. Using Watson's and the recursive equations satisfied by matrix elements of local operators, I present the computation of the form factors of the elementary field $\phi(x)$ and the stress-energy tensor $T_{\mu\nu}(x)$ of the theory.Comment: 19pp, LATEX version, (talk at Como Conference on ``Integrable Quantum Field Theories''

Systematic 1/N1/N corrections for bosonic and fermionic vector models without auxiliary fields

In this paper, colorless bilocal fields are employed to study the large $N$ limit of both fermionic and bosonic vector models. The Jacobian associated with the change of variables from the original fields to the bilocals is computed exactly, thereby providing an exact effective action. This effective action is shown to reproduce the familiar perturbative expansion for the two and four point functions. In particular, in the case of fermionic vector models, the effective action correctly accounts for the Fermi statistics. The theory is also studied non-perturbatively. The stationary points of the effective action are shown to provide the usual large $N$ gap equations. The homogeneous equation associated with the quadratic (in the bilocals) action is simply the two particle Bethe Salpeter equation. Finally, the leading correction in $1\over N$ is shown to be in agreement with the exact $S$ matrix of the model.Comment: 24 pages, uses REVTEX macros. Replaced with final version to appear in Phys. Rev.

SU(N) Evolution of a Frustrated Spin Ladder

Recent studies indicate that the weakly coupled spin-1/2 Heisenberg antiferromagnet with next nearest neighbor frustration supports massive spinons when suitably tuned. The straightforward SU(N) generalization of the low energy ladder Hamiltonian yields two independent SU(N) Thirring models with N-1 multiplets of massive ``spinon'' excitations. We study the evolution of the complete set of low-energy dynamical structure factors using form factors. Those corresponding to the smooth (staggered) magnetizations are qualitatively different (the same) in the N=2 and N>2 cases. The absence of single-particle peaks preserves the notion of spinons stabilized by frustration. In contrast to the ladder, we note that the N=infinity limit of the four chain magnet is not a trivial free theory.Comment: 10 pages, RevTex, 5 figures; SU(N) approach clarifie

Multi-particle structure in the Z_n-chiral Potts models

We calculate the lowest translationally invariant levels of the Z_3- and Z_4-symmetrical chiral Potts quantum chains, using numerical diagonalization of the hamiltonian for N <= 12 and N <= 10 sites, respectively, and extrapolating N to infinity. In the high-temperature massive phase we find that the pattern of the low-lying zero momentum levels can be explained assuming the existence of n-1 particles carrying Z_n-charges Q = 1, ... , n-1 (mass m_Q), and their scattering states. In the superintegrable case the masses of the n-1 particles become proportional to their respective charges: m_Q = Q m_1. Exponential convergence in N is observed for the single particle gaps, while power convergence is seen for the scattering levels. We also verify that qualitatively the same pattern appears for the self-dual and integrable cases. For general Z_n we show that the energy-momentum relations of the particles show a parity non-conservation asymmetry which for very high temperatures is exclusive due to the presence of a macroscopic momentum P_m=(1-2Q/n)/\phi, where \phi is the chiral angle and Q is the Z_n-charge of the respective particle.Comment: 22 pages (LaTeX) plus 5 figures (included as PostScript), BONN-HE-92-3