Groebke–Blackburn–Bienaymé Reaction for DNA-Encoded Library Technology

This study presents a DNA-compatible synthesis of diverse 5-arylimidazo[1,2-a]pyridin-3-amine derivatives using the Suzuki–Miyaura reaction, followed by a Groebke–Blackburn–Bienaymé (GBB) reaction. The GBB reaction demonstrates a wide substrate scope, mild one-pot reaction conditions, and compatibility with subsequent enzymatic ligation, highlighting its potential in DNA-encoded library technology

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