Staying with the Trouble through Design: Critical-feminist Design of Intimate Technology

This dissertation explores staying with the trouble through design as a design theory of intimacy and intimate technology. To research and design with the subject of intimacy is to trouble and to ask for trouble, and by staying with the trouble of intimacy, to paraphrase Donna Haraway, I articulate and perform a way of designing not as a way out of trouble, but as a way of making trouble and staying with the trouble. I argue that by staying with the trouble, designers may learn to be “truly present” and respond to social, cultural and political issues of intimate technology.The methodology interweaves design research, feminist technoscience, critical theory and software studies into a critical-feminist design methodology. As a response to design and designing intimate technology I have engaged in Donna Haraway’s “Staying with the Trouble” (Donna J. Haraway 2016) and solutionism as a critique of technology development, as well as feminist theories on fantasies of “the good life” and gender and technology, and critical theories on the role of intimacy in digital culture.Within the field of interaction design research, this dissertation’s contribution can be divided into three parts: 1) an exploration of the role of intimate technologies in our everyday lives and ways of being, 2) a critical and feminist design methodology of staying with the trouble through design, and 3) design proposals that stay with the trouble of designing with intimacy.My design research has evolved through four design projects that interweave different intimate topics and technologies through varied design practices: 1. PeriodShare: an internet-connected menstrual cup. 2. Marcelle: a wearable sex toy reacting on wifi-activity. 3. Ingrid: a woman living with electromagnetic hypersensitivity. And 4. Intimate Futures: two digital personal assistants where one is pushing back on sexual harassment and the other is assisting with hormone level tracking.The main contribution of the dissertation is the design methodology staying with the trouble through design, which is an anti-solutionist approach to design that interweaves the situated, personal and political role of design. By responding to/with trouble, rather than designing solutions to problems, staying with the trouble through design aims to better understand the conflicts and responsibilities involved in complex social, cultural and political issues, in order to imagine and design still possible futures. The design methodology interweaves three practices that unfold the self-reflective, ethnographic and collaborative process of staying with the trouble through design. The first practice, the willful practice of Staying with the Wrong, is a continuous process of becoming a feminist designer and it includes actively learning to be present; question the given as given, stay with the feelings you wish would go away, continuously practice self-reflection on own positionality and using feminist humour when designing with taboos. The second practice, Curious Visiting, encourages the designer to go beyond their own positionality, by listening to stories of pleasure and pain and visiting ongoing pasts and alternatives nows. This challenges the designer’s notion of the present by interweaving fact and fiction, and it highlights that this practice is never innocent but involves risks. Lastly, the third practice Collective Imagining highlights how design by proposing future change can respond to and/or with trouble and how we collectively can engage with futures to rewrite collective imaginings and tell other possible stories within and across social and cultural contexts. Together, these three interwoven practices propose a way of staying with the trouble through design, as a feminist contribution to current critical approaches within interaction design.

Combining pressing and alkaline extraction to increase protein yield from Ulva fenestrata biomass

Many seaweed species have a high production potential and attract interest as future protein sources. A high fiber and ash content, however, demand extraction of the protein to improve its digestibility and protein utilization in food or feed. This study explores three different approaches for protein extraction from Ulva fenestrata in order to maximize the protein extraction yield. Soluble protein was recovered either by mechanical pressing or by homogenization and osmotic shock of the biomass followed by alkaline extraction. The soluble protein was then concentrated by isoelectric precipitation. A combined procedure was carried out by pressing the biomass and following subjecting the residual pulp fraction to homogenization, osmotic shock and alkaline extraction. The three methods were ranked as follows with respect to protein extraction yield (as % of biomass protein); the combined method (23.9 \ub1 0.3%)> the alkaline extraction (6.8 \ub1 0.2%)> mechanical pressing (5.0 \ub1 0.2%). The significant increase when combining the methods was ascribed to a high precipitation yield after alkaline extraction of the pulp, hypothesized to be due to a reduced conductivity of the alkali-soluble protein fraction when derived from pulp rather than whole biomass

Multimorbidity and mortality thereof, among non-western refugees and family reunification immigrants in Denmark:A register based cohort study

Abstract Background The prevalence of multimorbidity, defined by having two or more chronic diseases, is increasing in many Western countries. Simultaneously, the migrant population in Western countries has increased, making up a growing proportion of European populations. This study aims i) to determine the quantity and quality of multimorbidity patterns among refugees and family reunification immigrants from non-Western countries compared to Danish-born, and ii) to compare the mortality burden among those with multimorbidity in the two groups. Methods Through the Danish Immigration Service, we conducted a historically prospective cohort study. We identified a total of 101,894 adult migrants who were sub-categorised into refugees and family reunification immigrants, and matched them to a Danish-born comparison group 1:6 on age and sex. Through the Danish National Patient Registry, we obtained information on all in- and outpatient data on hospitalised and ambulatory patients. To assess multimorbidity we used Charlson Comorbidity Index based on ICD-10 codes, together with ICD-10 diagnostic categories for psychiatric disease. We used Cox regression analysis to calculate risk of multimorbidity and risk of mortality in people with multimorbidity. Results Overall refugees had higher risk of multimorbidity compared to Danish-born, while family reunification immigrants had a lower risk. When adjusting for civil status and mean income, the risk was lower for all migrant groups compared to Danish-born. Risk of mortality in people with multimorbidity, was lower for all migrant groups, compared to Danish-born. Conclusion Refugees are an at-risk group for multimorbidity, however, mortality among those with multimorbidity is lower in all migrant groups compared to Danish-born

Ulva fenestrata protein – Comparison of three extraction methods with respect to protein yield and protein quality

Seaweed is gaining attention as a possible alternative and sustainable source of proteins. This study investigates three protein extraction methods and their effect on protein yield and quality when applied to Ulva fenestrata. Two of the methods included alkaline extractions (pH-shifts); one version solubilizing the proteins at pH 8.5 and one solubilizing them at pH 8.5 followed by pH 12 (pH 8.5 + 12). The third method was a mechanical pressing, using a double screw press. All extraction methods were followed by isoelectric precipitation to concentrate the proteins. Extraction at pH 8.5 gave the significantly highest total protein yield after the isoelectric precipitation, followed by extraction at pH 8.5 + 12 and lastly mechanical extraction gave the lowest yield. Proteins extracted with both alkaline methods had a significantly higher solubility at pH 7 and pH 9, compared to proteins from the mechanical pressing. There were no significant differences between the three methods in total D/L-amino acid ratio. Amino acid cross-links measured as lysinoalanine (LAL) and lanthionine (LAN) where found in significantly higher amounts in alkali-extracted proteins compared to mechanically extracted, however not to a degree that expect to compromise functional or nutritional quality. Further, no significant difference in protein in vitro digestibility was found between extraction methods. In conclusion, results indicated that protein extraction at pH 8.5 can be recommended, especially regarding total protein yield and solubility of the final protein extract

Status and Clinical Experiences from the Challenge Trial – A Randomized Controlled Trial Investigating Virtual Reality-based Therapy for Auditory Hallucinations

Background: Auditory verbal hallucinations are a prevalent symptom in schizophrenia and other psychotic disorders, affecting around 70% of patients. A sizable proportion does not achieve adequate treatment response with current interventions, including antipsychotic medication. Virtual reality-based therapy (VRT) shows promise as a new intervention. Methods: The Challenge Trial is a randomized controlled study examining the efficacy of VRT compared to standard treatment for auditory hallucinations in patients with psychotic disorders. In the intervention arm, virtual reality software and voice modulation are used to design a visual representation of the patient's voice (an avatar) and to transform the therapist's voice to sound like the voice the patient hears. The aim is to foster a dialogue for the patient to strengthen their power, practice self-efficacy, and alter their relation to the voice. During therapy, the avatar becomes more compassionate and/or less powerful. Results: Quantitative data are currently unavailable as recruitment is ongoing. Instead, the design and intervention are presented along with recruitment data, retention rates, and case vignettes. Early clinical experiences are promising, with high acceptability and tolerance among patients. The trial has successfully enrolled a diverse patient population, including those with long-standing histories of hospitalization, medication use, and chronic hallucinations. The effectiveness of VRT varies, for example, some patients have reported significant reductions in the frequency of voices and associated distress, whereas others have primarily noted improvements in emotional responses to the voices. Conclusions: Based on the first 2 years of the Challenge Trial, VRT shows considerable promise as a potential treatment for auditory verbal hallucinations

Standard wound management versus negative-pressure wound therapy in the treatment of adult patients having surgical incisions for major trauma to the lower limb — a two-arm parallel group superiority randomised controlled trial : protocol for Wound Healing in Surgery for Trauma (WHIST)

Introduction Patients with closed high-energy injuries associated with major trauma have surprisingly high rates of surgical site infection in incisions created during fracture fixation. One factor that may reduce the risk of surgical site infection is the type of dressing applied over the closed surgical incision. In this multicentre randomised clinical trial, negative-pressure wound therapy will be compared with standard dressings with outcomes of deep infection, quality of life, pain and disability. Methods and analysis Adult patients presenting to hospital within 72 hours of sustaining major trauma, requiring a surgical incision to treat a fractured lower limb, are eligible for inclusion. Randomisation, stratified by trial centre, open/closed fracture at presentation and Injury Severity Score (ISS) ≤15 versus ISS ≥16 will be administered via a secure web-based service using minimisation. The random allocation will be to either standard wound management or negative-pressure wound therapy. Trial participants will usually have clinical follow-up at the local fracture clinic for a minimum of 6 months, as per standard National Health Service practice. Diagnosis of deep infection will be recorded at 30 days. Functional, pain and quality of life outcome data will be collected using the Disability Rating Index, Douleur Neuropathique Questionnaire and Euroqol - 5 Dimension - 5 level (EQ-5D-5L) questionnaires at 3 months and 6 months postinjury. Further data will be captured on resource use and any late postoperative complications. Longer term outcomes will be assessed annually for 5 years and reported separately. Ethics and dissemination National Research Ethics Committee approved this study on 16 February 2016 16/WM/0006. The National Institute for Health Research Health Technology Assessment monograph and a manuscript to a peer-reviewed journal will be submitted on completion of this trial. The results of this trial will inform clinical practice on the clinical and cost-effectiveness of the treatment of this injury