An environmental monitoring study of hard bottom reef areas near the Charleston Ocean Dredged Material Disposal Site

In order to monitor conditions in and around the Charleston Ocean Dredged Material Disposal Site and its potential impact on surrounding hard bottom reef habitats a large monitoring effort has been ongoing. The current hard bottom reef monitoring study is part of a larger program to monitor conditions in and around the Charleston ODMDS. Specific objectives of the current hard bottom reef monitoring project described here were to document any changes in sedimentation rates, sponge/coral density, sponge/coral condition, finfish assemblages, and areal extent of six hard bottom reef areas over a five year period

An environmental assessment of the Charleston Ocean Dredged Material Disposal Site and surrounding areas : physical and biological conditions after completion of the Charleston Harbor Deepening Project

A monitoring program of the physical and biological condition of bottom habitats within and surrounding the Charleston Ocean Dredged Material Disposal Site was completed after the conclusion of disposal activities associated with the 1999-2002 Charleston Harbor Deepening Project. Approximately 20-25 million cubic yards of inner harbor and entrance channel materials were placed at the ODMDS as part of the project. Findings presented here include analyses of sediment characteristics, sediment contaminants, and benthic assemblages in the disposal zone, inner boundary zone, and outer boundary zone

No Remdesivir Resistance Observed in the Phase 3 Severe and Moderate COVID-19 SIMPLE Trials

Remdesivir (RDV) is a broad-spectrum nucleotide analog prodrug approved for the treatment of COVID-19 in hospitalized and non-hospitalized patients with clinical benefit demonstrated in multiple Phase 3 trials. Here we present SARS-CoV-2 resistance analyses from the Phase 3 SIMPLE clinical studies evaluating RDV in hospitalized participants with severe or moderate COVID-19 disease. The severe and moderate studies enrolled participants with radiologic evidence of pneumonia and a room-air oxygen saturation of ≤94% or >94%, respectively. Virology sample collection was optional in the study protocols. Sequencing and related viral load data were obtained retrospectively from participants at a subset of study sites with local sequencing capabilities (10 of 183 sites) at timepoints with detectable viral load. Among participants with both baseline and post-baseline sequencing data treated with RDV, emergent Nsp12 substitutions were observed in 4 of 19 (21%) participants in the severe study and none of the 2 participants in the moderate study. The following 5 substitutions emerged: T76I, A526V, A554V, E665K, and C697F. The substitutions T76I, A526V, A554V, and C697F had an EC50 fold change of ≤1.5 relative to the wildtype reference using a SARS-CoV-2 subgenomic replicon system, indicating no significant change in the susceptibility to RDV. The phenotyping of E665K could not be determined due to a lack of replication. These data reveal no evidence of relevant resistance emergence and further confirm the established efficacy profile of RDV with a high resistance barrier in COVID-19 patients

PEARLS OF PRACTICE. Using Sport Psychology Consultants, Part II: Why Aren\u27t They Used More Often?

The article focuses on the three common reasons why sport psychology consultants (SPCs) are not included on a sports medicine team. It says that the stigmas and negative connotations on psychologists can lead to a degree of apprehension on the view by athletes and coaches on SPCs. It states that the SPCs\u27 lack of sport-specific knowledge can be a hindrance for the members of a sports medicine team. It also mentions the political and cultural problems in the sport and rehabilitation environment