Fertility-sparing treatment of endometrial cancer - is it possible? A case study

Background: Endometrial cancer is the most common gynecological malignant neoplasm, which occurs in the majority of cases postmenopausally. The current standard of treatment is surgical - total hysterectomy.  However, it may also occur in younger patients, who are planning pregnancy and want to choose fertility-sparing treatment. For those patients oral high dose progestin therapy with or without hysteroscopic resection should be proposed. It is usually a good option for women with well-differentiated (G1) cancers. For patients with higher grade (G2, G3) or contraindications to progestins, fertility-sparing treatment of endometrial cancer seems impossible. Case report: We present the case of a 34-year old woman diagnosed gynecologically due to abnormal bleeding from the genital tract. Based on USG, she was diagnosed with endometrial polyp. As a treatment, hysteroscopic resection was performed. In the histopathological evaluation G2 endometrial cancer was diagnosed. The standard approach would be a total hysterectomy, but the patient was interested in fertility-sparing options. Due to contraindications to progestins a total hysteroscopic resection was performed counseling the patient about the risks of a novel approach. Histopathology revealed no residual disease and no other lesions during the first year of observations occurred. Conclusion: Total hysteroscopic resection without further progestin therapy may offer the possibility to treat G2 endometrial cancer despite contraindications to the administration of progestins. Our case report should also encourage further evaluation of fertility-sparing management of endometrial cancer with higher than G1 grade

The Impact of Diet on Male Fertility

Introduction: Infertility is a reproductive health issue where the inability to conceive after 12 months of regular unprotected intercourse affects about 8 to 12% of couples of reproductive age. Factors such as diet, lifestyle, and exposure to toxins can negatively impact men's reproductive capacity, including semen parameters and gonadal function. The impact of diet on male fertility, including hormone levels and the process of spermatogenesis, is the subject of intense research. Aim of the Study: This study aims to review current scientific research on the impact of diet on male fertility to provide updated knowledge on this topic, essential for preventive and therapeutic actions in this field. Materials and Methods: A comprehensive review of scientific and medical literature was conducted using PubMed and Google Scholar databases. The search terms included: impact of diet on male fertility, impact of diet on semen parameters, impact of diet on semen quality, male fertility, diet and male fertility, types of diets and fertility. Conclusion: Diet plays a crucial role in male fertility, affecting semen quality. It is recommended to consume meat in moderation, especially organic, and to increase the intake of fish rich in omega-3 while avoiding contaminants. Regular consumption of fruits, vegetables, and grains improves semen parameters, while limiting sweets, sugary drinks, and alcohol, as well as quitting smoking, is beneficial for reproductive health. Men planning fatherhood should also consider reducing cannabis use. Future research should focus on the impact of individual dietary factors on male fertility

Methods of Prevention and Mitigation of Autoimmune Diseases - A Review of The Literature

Introduction and purpose: Autoimmune diseases are conditions where the body’s immune system is unable to distinguish between auto- and foreign antigens and mistakenly attacks its cells, tissues, and organs. In recent years it became major public health concern because of the increasing diagnosis rate. Currently, about 5% of the population in Western countries is affected by such diseases, more often in women population. The exact cause of autoimmune diseases is unknown, although most probably it results from a combination of genetic predisposition, environmental risk factors and immune dysregulation. Development of autoantigen-specific lymphocytes and autoantibodies might be decisive in starting the process of autoimmunity. Most common medication used in autoimmune diseases treatment are nonsteroidal anti-inflammatory drugs (NSADs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs). Additionally, there is biological medication available for many of them. It is known that non-pharmacological interventions, such as specific diets, supplementation or physical exercise is useful to mitigate the disease or even to prevent the body from its onset. Materials and methods: The data for the article was found using the PubMed and Google Scholar websites. The key words used for the search included: ‘diet and autoimmunity’, ‘autoimmunity and estrogens’, ‘microbiota and autoimmunity’. Articles not written in English, conference abstracts only and duplicated papers were excluded. Conclusions: There is still no cure for autoimmune diseases, although various prevention and mitigation strategies can help manage these conditions and improve quality of life for affected individuals. However, for the use of some of them, evidence-based recommendations are not available. This review highlights current non-pharmacological therapeutic options.

The Influence of diet on the course and activity of Crohn's disease and ulcerative colitis - a review of available literature

Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the digestive tract. It is a clinical entity that includes: Crohn's disease (CD) and ulcerative colitis (UC). Food intake is an important environmental factor that influences the development of IBD. This article reviews studies on different dietary options and their effects on the course and activity of Crohn's disease and ulcerative colitis.  Materials and methods: A review of the literature available in the PubMed database was carried out, using the key words: ”inflammatory bowel disease”; ”Crohn disease”; ”diet”; “nutrition”; „colitis ulcerosa”. Results: Appropriate diet selection is important in the course of inflammation in the intestines. It influences disease activity. It turns out that the diet improves inflammation parameters, clinical symptoms, and quality of life. In patients with inflammatory bowel disease, one should also remember about deficiencies such as iron, vitamin D or protein deficiency, the demand of which is increased in sick patients compared to the general population. Conclusions: An individualized approach to nutritional therapy may be one of the main branches of treatment for patients with inflammatory bowel diseases. However, there is a need for further research on larger groups of patients in order to effectively implement it into treatment standards.

Creatine supplementation in sport and medicine - a review of recent reports

Introduction and objective The role of creatine as a dietary supplement to enhance ergogenic performance in strength sports is well established and researched, both among professionals and amateurs. In this article, we will focus not only on analysing creatine supplementation as an agent used in sport, but also as a supplement that may find a medical application. Review methods A literature search of Google Scholar and PubMed medical databases from the last eight years (2016-2024) was performed. Articles were searched in English using the following keywords: Creatine, Supplementation, Sport, Athletes Abbreviated description of the state of knowledge The role of creatine in strength sports is firmly established. Recent reports present creatine as an agent with many other uses. Endurance sports, rehabilitation or injury prevention are just a few of the areas mentioned where creatine finds its use. In the medical sciences, it is of interest to fields such as neurology, psychiatry, cardiology, geriatrics or rheumatology. Although many misconceptions have grown up around creatine, one of the best confirming its safety may be the fact that there are reports of benefits for pregnant women and the foetus. Summary Research shows the extensive use of creatine in various sports and medical fields. The high safety profile and efficacy in resistance training has been confirmed and is now known to an increasing number of people, not only in competitive sport. New promising reports in many areas of medicine and sport are described in an increasing number of reports, with the need for further research, often using more widely available modern technologies

Does diet influence the development and treatment of endometriosis? - A literature review

Introduction and objective: Endometriosis is a chronic disease that can cause symptoms that significantly worsen the quality of life of patients. Treatment methods often fail to produce satisfactory results. Therefore, there is growing interest in the potential role of diet in prevention and management of endometriosis. The aim of the review is to analyze available scientific literature on the impact of diet on the development and alleviation of endometriosis symptoms and the possibility of its use in clinical practice. Brief description of the state of knowledge: Both nutrient deficiencies and excesses can affect health, with gene-nutrient interactions playing a key role in disease prevention and progression. Nutrition can alter gene expression and disease susceptibility, making the study of diet's influence on gynecological diseases like endometriosis important. Research suggests dietary changes can improve symptoms and quality of life for patients with endometriosis. Conclusions: This study confirms that consuming or limiting some of the nutrients can reduce the risk of developing endometriosis and alleviate its symptoms. However, there are many contradictions in the research. The role of diet and nutrition in endometriosis still remains an unexplored area that requires further investigation