Recherche et jumelage de résidence : un webinaire par les presque pairs

Implication Statement: Medical students have a wide range of opinions and expectations about research and face many challenges when pursuing it. Online research webinars have the potential to teach medical students about the value of research for various competitive and non-competitive specialties, while also providing them with the opportunity to network with recent medical graduates. When hosted virtually, these events have the potential to reach medical student across multiple provinces and provide them with insight on the different facets of research.Énoncé des implications de la recherche: Les étudiants en médecine ont des opinions et des attentes très diversifiées en ce qui concerne la recherche et ils sont confrontés à de nombreux défis lorsqu’ils s’y lancent. Les webinaires sur la recherche peuvent renseigner les étudiants sur l’intérêt de la recherche dans diverses spécialités à forte concurrence ou non, tout en leur donnant l’occasion de réseauter avec des diplômés récents. Ce type d’activités, lorsqu’elles sont tenues virtuellement, ont le potentiel de toucher les étudiants en médecine de plusieurs provinces et de leur donner un aperçu des différentes facettes de la recherche

Research and residency match: A near-peer online webinar

Implication StatementMedical students have a wide range of opinions and expectations about research and face many challenges when pursuing it. Online research webinars have the potential to teach medical students about the value of research for various competitive and non-competitive specialties, while also providing them with the opportunity to network with recent medical graduates. When hosted virtually, these events have the potential to reach medical student across multiple provinces and provide them with insight on the different facets of research.Énoncé des implications de la rechercheLes étudiants en médecine ont des opinions et des attentes très diversifiées en ce qui concerne la recherche et ils sont confrontés à de nombreux défis lorsqu’ils s’y lancent. Les webinaires sur la recherche peuvent renseigner les étudiants sur l’intérêt de la recherche dans diverses spécialités à forte concurrence ou non, tout en leur donnant l’occasion de réseauter avec des diplômés récents. Ce type d’activités, lorsqu’elles sont tenues virtuellement, ont le potentiel de toucher les étudiants en médecine de plusieurs provinces et de leur donner un aperçu des différentes facettes de la recherche

Persistent Pain due to Cement Protrusion After Total Knee Arthroplasty: A Report of Three Cases

Chronic lateral knee pain after uneventful total knee arthroplasty can be challenging to manage. We present 3 cases where the pain transiently resolved with injections of local anesthetic. Diagnostic arthroscopy revealed cement protrusion at the lateral femoral bone-prosthesis interface. Passive full knee extension during the curing phase is routine to ensure cement pressurization and optimal bonding. This may enable cement extrusion at the lateral femoral interface and result in persistent pain. Therefore, prevention measures should include thorough visualization of the implant after cementing. Arthroscopic cement excision en bloc is a minimally invasive procedure to treat these patients

Management of bone metastasis with zoledronic acid: A systematic review and Bayesian network meta-analysis

Background: While considered the mainstay of treatment for specific bone metastases, ZA is used predominantly to treat osteolytic lesions. The purpose of this network meta-analysis is to compare ZA to other treatment options in its ability to improve specific clinical outcomes in patients with bone metastases secondary to any primary tumor. Methods: PubMed, Embase and Web of Science were systematically searched from inception to May 5th, 2022. Keywords used were solid tumor, lung neoplasm, kidney neoplasm, breast neoplasm, prostate neoplasm, ZA and bone metastasis. Every randomized controlled trial and non-randomized quasi-experimental study of systemic ZA administration for patients with bone metastases and any comparator were included. A Bayesian network meta-analysis was done on the primary outcomes including number of SREs, time to developing a first on-study SRE, overall survival, and disease progression-free survival. Secondary outcome was pain at 3, 6 and 12 months after treatment. Results: Our search yielded 3861 titles with 27 meeting inclusion criteria. For the number of SRE, ZA in combination with chemotherapy or hormone therapy was statistically superior to placebo (OR 0.079; 95 % CrI: 0.022–0.27). For the time to the first on study SRE, the relative effectiveness of ZA 4 mg was statistically superior to placebo (HR 0.58; 95 % CrI:0.48–0.77). At 3 and 6 months, ZA 4 mg was significantly superior to placebo for reducing pain with a SMD of −0.85 (95 % CrI:-1.6, −0.0025) and −2.6 (95 % CrI:-4.7, −0.52) respectively. Conclusions: This systematic review shows the benefits of ZA in decreasing the incidence of SREs, increasing the time to the first on-study SRE, and reducing the pain level at 3 and 6 months

Next-generation sequencing of non-small cell lung cancer at a Quebec health care cancer centre

Background: Lung cancer is the leading cause of cancer death in both men and women. Quebec has the highest lung cancer mortality out of all provinces in Canada, believed to be caused by higher smoking rates. Molecular testing for lung cancer is standard of care due to the discovery of actionable driver mutations that can be targeted with tyrosine kinase inhibitors. To date, no detailed molecular testing characterization of Quebec patients with lung cancer using next generation sequencing (NGS) has been performed. Materials and methods: The aim of this study was to describe the genomic landscape of patients with lung cancer (n = 997) who underwent NGS molecular testing at a tertiary care center in Quebec and to correlate it with clinical and pathology variables. Results: Compared to 10 other NGS studies found through a structured search strategy, our cohort had a higher prevalence of KRAS mutations (39.2%) compared to most geographical locations. Additionally, we observed a significant positive association between decreasing age and a higher proportion of KRAS G12C mutations. Conclusion: Overall, it remains important to assess institutional rates of actionable driver mutations to help guide governing bodies, fuel clinical trials and create benchmarks for expected rates as quality metrics