Background: Metabolic syndrome has become a significant problem, with the American Diabetes Association estimating the cost of diabetes and pre-diabetes in the United States alone to be 322billionperyear.Numerousclinicaltrialshavedemonstratedtheefficacyoflow−carbohydratedietsinreversingmetabolicsyndromeanditsassociateddisorders.Aim: Thisstudywasdesignedtoexaminehowvoluntaryadherentstoalow−carbohydratedietrateitseffectivenessandsustainabilityusinganonlinesurvey.Settingandmethods: The57−questionsurveywasadministeredonlineandsharedinternationallyviasocialmediaand‘low−carb’communities.Whereappropriate,chi−squaredtestsandpaired t−testswereusedtoanalysetheresponses.Results: Therewere1580respondents.Themajorityofrespondentshadconsumedlessthan100gofcarbohydratesperdayforoverayear,typicallyforreasonsofweightlossordiseasemanagement.Therewasareporteddecreaseinwaistcircumferenceandweightwithasimultaneousdecreaseinhungerandincreaseinenergylevel.Ofthosewhoprovidedlaboratoryvalues,themajoritysawimprovementsintheirHbA1c,bloodglucosemeasurements,andlipidpanelresults.Therewasareductioninusageofvariousmedications,and25288 for those respondents. In particular, the usage of pain relievers and anti-inflammatories dropped with a simultaneous decreased rating of pain and increase in mobility.
Conclusion:Â We conclude that low-carbohydrate diets are a sustainable method of metabolic syndrome reversal in a community setting
Recently renamed, metabolic dysfunction-associated steatotic liver disease remains a leading cause of chronic liver disease worldwide. Regular physical activity is recommended as a treatment for all with this condition because it is highly efficacious, especially when exercise training is undertaken with a specific goal in mind. Despite decades of research demonstrating exercises efficacy, key questions remain about the mechanism of benefit and most efficacious dose, as well as the independent impact on liver histology. To answer these questions, we present the design of a 16-week randomized controlled clinical trial of 45 adults aged 18-69 years with metabolic dysfunction-associated steatohepatitis. The primary aim of this study is to better understand the dose required and mechanisms to explain how exercise impacts multiple clinical end points in metabolic dysfunction-associated steatohepatitis. The primary outcome is MRI-measured liver fat. Secondary outcomes include other biomarkers of liver fibroinflammation, liver histology, and mechanistic pathways, as well as cardiometabolic risk and quality of life. This is the first study to compare different doses of exercise training to determine if there is a differential impact on imaging and serum biomarkers as well as liver histology