26 research outputs found
Ability of various inserts to promote endothelium cell culture for the establishment of coculture models
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Induction of CYP3A and associated terfenadineN-dealkylation in rat hepatocytes cocultured with 3T3 cells
No full textPC: PS liposomes induce a recruitment of neutrophils and the release of TNFa in the lungs of mice sensitized with Saccharopolyspora rectivirgula
No full textNew promising compounds with in vitro nanomolar activity against Trypanosoma cruzi
No full textInternational audienceThe antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells
