Determination of Stray Inductance of Low-Inductive Laminated Planar Multiport Busbars Using Vector Synthesis Method

Laminated busbars connect capacitors with switching power modules, and they are designed to have low stray inductance to minimize electromagnetic interference. Attempts to accurately measure the stray inductance of these busbars have not been successful. The challenge lies with the capacitors, as they excite the busbar producing their individual stray inductances. These individual stray inductances cannot be arithmetically averaged to establish the total stray inductance that applies when all the capacitors excite the busbar at the same time. It is also not possible to measure the stray inductance by simultaneous excitation of each capacitor port using impedance analyzers. This paper presents a solution to the above dilemma. A vector synthesis method is proposed, whereby the individual stray inductance from each capacitor port is measured using an impedance analyzer. Each stray inductance is then mapped into an xyz frame with a distinct direction. This mapping exercise allows the data to be vectored. The total stray inductance is then the sum of all the vectors. The effectiveness of the proposed method is demonstrated on a busbar designed for H-bridge inverters by comparing the simulation and practical results. The absolute error of the total stray inductance between the simulation and the proposed method is 0.48 nH. The proposed method improves the accuracy by 14.9% compared to the conventional technique in measuring stray inductances

Positive response to trastuzumab deruxtecan in a patient with HER2-mutant NSCLC after multiple lines therapy, including T-DM1: a case report

Human epidermal growth factor 2 (HER2) mutations are uncommon in non-small cell lung cancer (NSCLC), and the lack of established, effective, targeted drugs has resulted in a persistently poor prognosis. Herein, we report the case of a non-smoking, 58-year-old man diagnosed with lung adenocarcinoma (cT3N0M1c, stage IVB) harboring a HER2 mutation (Y772_A775dupYVMA) and PD-L1 (-). The patient’s Eastern Cooperative Oncology Group performance status (PS) score was assessed as 1. He commenced first-line treatment with chemotherapy, followed by immuno-chemotherapy, and with disease progression, he received HER2-targeted therapy and chemotherapy with an anti-angiogenic agent. However, HER2-targeted therapy, including pan-HER tyrosine kinase inhibitors (afatinib, pyrotinib, and pozitinib) and antibody–drug conjugate (T-DM1), produced only stable disease (SD) as the best response. After the previously described treatment, primary tumor recurrence and multiple brain metastases were observed. Despite the patient’s compromised overall physical condition with a PS score of 3-4, he was administered T-DXd in addition to whole-brain radiotherapy (WBRT). Remarkably, both intracranial metastases and primary lesions were significantly reduced, he achieved a partial response (PR), and his PS score increased from 3-4 to 1. He was then treated with T-DXd for almost 9 months until the disease again progressed, and he did not discontinue the drug despite the occurrence of myelosuppression during this period. This is a critical case as it exerted an effective response to T-DXd despite multiple lines therapy, including T-DM1. Simultaneously, despite the occurrence of myelosuppression in the patient during T-DXd, it was controlled after aggressive treatment

Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm

This work was partially supported by grants from NSFC (81773674, 81573383, and 21473041), NSFHP (2017CFA024, 2017CFB711, and 2016ACA126), the Applied Basic Research Program of WMBST (2019020701011429), Tibet Autonomous Region Science and Technology Plan Project Key Project (XZ201901-GB-11), Project First-Class Disciplines Development Supported by Chengdu University of Traditional Chinese Medicine (CZYJC1903), and Health Commission of Hubei Province Scientific Research Project (WJ2019M177 and WJ2019M178).Peer reviewedPublisher PD

Confront or Comply? Managing Social Risks in China’s Urban Renewal Projects

Social sustainability is a major concern of planners and local officials when urban renewal projects are being conducted. Extreme individualism can potentially cause conflicts of interest, making urban renewal in Western cities fraught with various types of social risks. As a country with a deep-rooted socialist tradition, urban renewal projects in China are influenced by collectivist culture and show different features from those of the West. The objective of this research is to investigate how different stakeholders in urban redevelopment projects, including local residents, social organizations, the local state, and developers, interact with each other and how the associated social risks are hedged against. Using a recent well-known project in the city of Guangzhou, the authors attempt to present the latest progress in social risk management in China. With support from a government-sponsored project, the authors have conducted a questionnaire-based survey with a year-long fieldwork follow-up. Using ATLAS.ti software, we found that that “residents’ demand”, “status of collaboration”, and “degree of trust” are the keys to risk management. The results of an ordered probit model show that residents are worried about overall planning, the relocation timetable, and whether their personal needs are taken into account. It is also indicated that the timely disclosure of project information, high-quality public participation, and a reasonable compensation plan can possibly boost the support rate. The authors suggest that utilizing China’s collectivist culture could be an effective way to mitigate social risks, and residents’ personal interests should also be respected

Spring Wheat–Summer Maize Annual Crop System Grain Yield and Nitrogen Utilization Response to Nitrogen Application Rate in the Thermal–Resource–Limited Region of the North China Plain

Spring wheat–summer maize (SWSM) annual crop systems were formed to satisfy the maize grain mechanized harvest thermal requirement in the thermal–resource–limited region of the North China Plain. However, the nitrogen (N) application rate effect on SWSM annual yield formation, N accumulation and utilization were barely evaluated. Two–year field experiments were conducted to evaluate the effects of the N application rate on the annual yield of SWSM, observe N accumulation and utilization, and identify the optimized N application. The experiments were conducted under 5 N levels of 0 (N0), 180 (N180), 240 (N240), 300 (N300), and 360 (N360) kg ha−1. The results showed that spring wheat, summer maize and annual cereal yield under the N240 and N480 treatments obtained the highest grain yield (GY) of 5038, 1282 and 16,320 kg ha−1, respectively, and the optimal N application rate was estimated using a linear–plateau model to be 231–307, 222–337 and 463–571 kg ha−1 with maximum GY of 4654–5317, 11,727–12,003 and 16,349–16,658 kg ha−1, respectively. With the increase in the N application rate, the dry matter accumulation (DM) were significantly increased by 16.9–173.5% for spring wheat and 11.1≈–76.8% for summer maize, respectively; and the annual cereal DM was 15.1–179.7% greater than that with N0 treatment, respectively. Spring wheat, summer maize and the annual cereal total N accumulation (TN) under N360 and N720 treatments were significantly increased by 5.4–19.1%, 16.6–32.3% and 11.5–26.2%, respectively, compared to the other treatments; however, N use efficiency for biomass and grain production (NUEbms and NUEg) were decreased significantly by 10.9–13.6% and 8.9–20.7%, 6.8–13.8% and 12.2–15.6%, and 5.5–11.7% and 10.0–16.0%, respectively. Meanwhile, the N partial factor productivity (PFPN), N agronomy use efficiency (ANUE), N recovery efficiency (NRE) and N uptake efficiency (NEupk) under the N240 treatment for spring wheat and summer maize obtained high levels of 20.99 and 47.01 kg−1, 9.27 and 16.35 kg−1, 32.53% and 32.44%, and 0.85 and 0.72 kg−1, respectively. Correlation analysis showed that the N application rate, TN and NEupk played significantly positive roles on GY, spring wheat spilke grain number, summer maize ear grain number and 1000–grain weight, DM LAImax and SPADmax, while NUEbms, NUEg, PFPN and ANUE always played negative effects. These results demonstrate that spring wheat, summer maize and annual cereal obtained the highest GY being 4654–5317, 11,727–12,003 and 16,349–16,658 kg ha−1 with the optimal N application rate 231–307, 222–337 and 463–571 kg ha−1, respectively, which provide N application guidance to farmer for spring wheat–summer maize crop systems to achieve annual mechanical harvesting in the thermal–resource–limited region of the North China Plain

Green Manure Return Strategies to Improve Soil Properties and Spring Maize Productivity under Nitrogen Reduction in the North China Plain

In order to study the effect of green manure return for stabilized spring maize (Zea mays L.) grain yield (GY) we reduced nitrogen fertilizer input by regulation and examined effects on soil nutrients, enzyme activity, and fungal communities. This two-year field experiment was conducted in the North China Plain. The field experiment was undertaken with a split-plot design; the primary plots were winter fallow (WF) and green manure (GM), and the split-plots were five N application rates of 0 (N0), 189 (N189), 216 (N216), 243 (N243), and 270 (N270) kg ha−1. The results showed that, spring maize GY under GM treatments (GYGM) were significantly increased by 5.38–11.68% more than WF treatment (GYWF), and GYWF and GYGM significantly increased by 35.9–91.5% and 80.1–135.5% across all N treatments. By linear-platform model analysis, spring maize under GM treatments obtained higher GY, reaching 1270.5–14,312.2 kg ha−1 with optimized N application rate at 238–265 kg ha−1, which resulted in a GY higher than WF (11,820.0 and 13,654.2 kg ha−1) and N reduced 11.2% (238 vs. 268 kg ha−1). GM treatment significantly increased soil organic carbon by 3.90–12.23% more than WF over all N application rates, and total nitrogen and available nitrogen were significantly increased by 3.79–15.76% and 4.87–17.29%, with total phosphorus and available phosphorus for GM higher than WF by 6.1–13.6% and 9.6–5.3%, respectively. However, there were lesser effects of GM on total potassium and available potassium. Compared to WF, soil catalase, sucrose, urease, and alkaline phosphatase activity were significantly increased by 6.2–16.4%, 5.8–48.1%, 3.3–21.5% and 11.5–82.3%, respectively, over all N application rates under GM over two years. GM increased Zygomycota and Basidiomycota relative abundances significantly, and reduced Thielavia, unclassified fungi, and Podospora relative abundances by 35.35%, 52.92% and 52.77% more than WF treatment, respectively. In summary, due to the GM return into fields, increased soil nutrients were available, which were positively affected by soil enzyme activity and fungal communities, and reduced nutrient requirements, and so the farmers could obtain a spring maize grain yield higher than 14,000 kg ha−1 with a reduced 11.2% N application rate from 268 kg ha−1 to 238 kg ha−1 by sowing winter green manure for a long time period in the North China Plain

Catalytic Asymmetric Construction of Chiral Hydropyridazines <i>via</i> Conjugate Addition of <i>N</i>‑Monosubstituted Hydrazones to Enones

The first example of a highly enantioselective and scalable formal diaza–ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines

Investigating protein interactions at solid surfaces : in situ, non-labeling techniques

The first example of a highly enantioselective and scalable formal diaza–ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines