A Comparative Study on Evaluation Methods of Fluid Forces on Cartesian Grids

We investigate the accuracy and the computational efficiency of the numerical schemes for evaluating fluid forces in Cartesian grid systems. A comparison is made between two different types of schemes, namely, polygon-based methods and mesh-based methods, which differ in the discretization of the surface of the object. The present assessment is intended to investigate the effects of the Reynolds number, the object motion, and the complexity of the object surface. The results show that the mesh-based methods work as well as the polygon-based methods, even if the object surface is discretized in a staircase manner. In addition, the results also show that the accuracy of the mesh-based methods is strongly dependent on the evaluation of shear stresses, and thus they must be evaluated by using a reliable method, such as the ghost-cell or ghost-fluid method

Water and Salt Balance in Agricultural Lands under Leaching with Shallow Subsurface Drainage Used in Combination with Cut-Drains

Secondary salinization of irrigated lands in drylands is often caused by rising groundwater levels. Open drainage is widely employed to control groundwater. However, salinity levels tend to remain high under malfunctioning drainage conditions. Shallow subsurface drainage may be a possible solution to prevent salt accumulation, although it is difficult for farmers to apply conventional tile drainage systems owing to construction costs. In this regard, we proposed a low-cost shallow subsurface drainage system used in combination with a new mole-drain drilling technology (cut-drain) developed in Japan, whose drainage capacity is similar to tile drain. The aim of this study is to evaluate the effect of the proposed system. The system was installed in a farmland, Uzbekistan. The experimental field was set with/without the system to observe the differences in the balance of water and salt. The results revealed that the remaining infiltrated water in the field decreased by approximately 26% and the removed net mass of salt was 14 Mg ha−1. The direction of salt movement changed from the deeper zone or surrounding field to the open drainage. Therefore, the proposed system can enhance salt removal from fields

Relative hypercoagulation induced by suppressed fibrinolysis after tisagenlecleucel infusion in malignant lymphoma

キメラ抗原受容体T細胞療法による血液凝固と線溶の変動を解析 --サイトカイン放出症候群に伴う凝固障害の病態解析にむけて--. 京都大学プレスリリース. 2022-06-20.Anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has facilitated progress in treatment of refractory/relapsed diffuse large B-cell lymphoma (DLBCL). A well-known adverse event after CAR-T therapy is cytokine release syndrome(CRS). However, the etiology and pathophysiology of CRS-related coagulopathy remain unknown. Therefore, we conducted a prospective cohort study to comprehensively analyze coagulation/ fibrinolysis parameters present in peripheral blood of adult DLBCL patients treated with tisagenlecleucel in a single institution. Samples were collected from 25 patients at 3 time points: before lymphocyte-depletion chemotherapy and on days 3 and 13 after CAR-T infusion. After infusion, all patients except 1 experienced CRS, and 13 required the administration of tocilizumab. A significant elevation in the plasma level of total plasminogen activator inhibitor 1 (PAI-1), which promotes the initial step of coagulopathy (mean, 22.5 ng/mL before lymphocyte-depletion and 41.0 on day 3, P = .02), was observed at the onset of CRS. Moreover, this suppressed fibrinolysis-induced relatively hypercoagulable state was gradually resolved after CRS remission with normalization of total PAI-1 to preinfusion levels without any organ damage (mean values of soluble fibrin: 3.16 µg/mL at baseline, 8.04 on day 3, and 9.16 on day 13, P < .01; and mean PAI-1: 25.1 ng/mL on day 13). In conclusion, a hypofibrinolytic and relatively hypercoagulable state concomitant with significant total PAI-1 elevation was observed at the onset of CRS even in DLBCL patients with mild CRS. Our results will facilitate understanding of CRS-related coagulopathy, and they emphasize the importance of monitoring sequential coagulation/fibrinolysis parameters during CAR-T therapy