HuR expression in non-cancer and cancer cells.

<p>IRS of nuclear HuR differed between cancer and non-cancer cells and between invasive and non-invasive cancer cells (A). Cytoplasmic HuR expression and the IRS of cytoplasmic HuR was higher in cancer than in non-cancer cells, and higher in invasive as compared to non-invasive cases (B).</p

Anti-cancer mechanisms of GTP.

<p>Schematic illustration of the role of GTP intake in the modulation of malignant characteristics in bladder cancer. GTP intake suppresses the expression of COX-2 and HO-1 directly and that of HO-1 and VEGF-A indirectly via regulation of cytoplasmic HuR expression. Downregulation of COX-2 and HO-1 or HO-1 and VEGF-A leads to inhibition of cancer cell proliferation and angiogenesis, respectively, thereby suppressing tumor growth.</p

HuR expression and GTP intake.

<p>IRS of cytoplasmic HuR increased from 14 to 24 weeks in the BBN but not the BBN + GTP group (A). Similar trends were also observed for MVD (B), proliferation index (C), and COX-2 (D), VEGF-A (E), and HO-1 (F) expression. On the other hand, tumor volume increased in both groups during this period (G).</p

Correlation between pathological characteristics and cancer-related molecules.

<p>Correlation between pathological characteristics and cancer-related molecules.</p

Representative examples of HuR immunoreactivity.

<p>HuR expression was observed in nuclei of both non-cancer (A) and cancer cells (B). In contrast, cytoplasmic HuR-positive non-cancer cells (arrows) were relatively rare (A). Although cytoplasmic expression of HuR was detected in bladder cancer cells (B and C), the percentage of cytoplasmic HuR-positive cancer cells in cases with muscle invasion (C) was higher than that in cases without muscle invasion (B).</p

Effect of green tea polyphenol intake on cytoplasmic HuR expression.

<p>Effect of green tea polyphenol intake on cytoplasmic HuR expression.</p

Additional file 1: Table S1. of The St. George’s Respiratory Questionnaire as a prognostic factor in IPF

Spearman’s correlation coefficients between SGRQ and baseline physiological measures. Table S2. The relationship between SGRQ and comorbidities. Table S3. SGRQ domain as predictors for mortality. (DOCX 29 kb

Spiral Array construction.

<p>A representative block was selected from each case, and two continuous straight regions of interest (X and Y axes) were selected and marked by reviewing hematoxylin and eosin-stained slides. Two 120.0-μm-thick sections were sliced from each block and aligned with the X and Y axes. The two sections were rolled together into a cylindrical form and cut along the line reflecting the X and Y axes. Spiral Array cores were embedded vertically into a recipient block. Four-μm-thick sections were prepared from the Spiral Array blocks for further histopathological evaluation.</p

Patient characteristics.

<p>Patient characteristics.</p

Additional file 1: of Ciliated muconodular papillary tumors of the lung with KRAS/BRAF/AKT1 mutation

Antibodies used for immunohistochemistry. (XLSX 10 kb