Flexible combination of multiple diagnostic biomarkers to improve diagnostic accuracy

In medical research, it is common to collect information of multiple continuous biomarkers to improve the accuracy of diagnostic tests. Combining the measurements of these biomarkers into one single score is a popular practice to integrate the collected information, where the accuracy of the resultant diagnostic test is usually improved. To measure the accuracy of a diagnostic test, the Youden index has been widely used in literature. Various parametric and nonparametric methods have been proposed to linearly combine biomarkers so that the corresponding Youden index can be optimized. Yet there seems to be little justification of enforcing such a linear combination. This paper proposes a flexible approach that allows both linear and nonlinear combinations of biomarkers. The proposed approach formulates the problem in a large margin classification framework, where the combination function is embedded in a flexible reproducing kernel Hilbert space. Advantages of the proposed approach are demonstrated in a variety of simulated experiments as well as a real application to a liver disorder study

Empirical analysis of the ship-transport network of China

Structural properties of the ship-transport network of China (STNC) are studied in the light of recent investigations of complex networks. STNC is composed of a set of routes and ports located along the sea or river. Network properties including the degree distribution, degree correlations, clustering, shortest path length, centrality and betweenness are studied in different definition of network topology. It is found that geographical constraint plays an important role in the network topology of STNC. We also study the traffic flow of STNC based on the weighted network representation, and demonstrate the weight distribution can be described by power law or exponential function depending on the assumed definition of network topology. Other features related to STNC are also investigated.Comment: 20 pages, 7 figures, 1 tabl

Stille Coupling of α-Acyloxybenzylstannanes with Acid Chlorides

Two widely-accepted models (open- and cyclic- transmetalation) are applied to explain the stereochemical outcome of the Stille coupling with organotin compounds containing an sp3 chiral center. However, it is still not possible to predict the stereochemical outcome of this type of Stille coupling before the reaction is conducted. To have a better understanding of the detailed mechanism involved, the Stille couplings of different α-acyloxybenzylstannanes with different acid chlorides were studied in this project

A review of high-speed electro-hydrostatic actuator pumps in aerospace applications: challenges and solutions

The continued development of electro-hydrostatic actuators (EHAs) in aerospace applications has put forward an increasing demand upon EHA pumps for their high power density. Besides raising the delivery pressure, increasing the rotational speed is another effective way to achieve high power density of the pump, especially when the delivery pressure is limited by the strength of materials. However, high-speed operating conditions can lead to several challenges to the pump design. This paper reviews the current challenges including the cavitation, flow and pressure ripples, tilting motion of rotating group and heat problem, associated with a high-speed rotation. In addition, potential solutions to the challenges are summarized, and their advantages and limitations are analyzed in detail. Finally, future research trends in EHA pumps are suggested. It is hoped that this review can provide a full understanding of the speed limitations for EHA pumps and offer possible solutions to overcome them

Research on wear prediction of piston/cylinder pair in axial piston pumps

The piston/cylinder pair is the critical lubricating interface of axial piston pumps. It suffers from excessive wear, especially under high output pressure. The performance degradation of the piston/cylinder pair is significant to be clarified. In this paper, a wear prediction method of the piston/cylinder pair is established by coupling the load-bearing and lubrication parameters calculation model and the wear calculation model. The models are validated through experiments. The experimental and simulated results show that the wear of two ends of the cylinder bore is severe in the specific ranges of circumferential angle. The time-varying wear process of the piston/cylinder pair can be obtained by using this method; therefore, the maintenance time can be predicted

Energy Efficiency Improvement of Heavy-Load Mobile Hydraulic Manipulator with Electronically Tunable Operating Modes

The conventional hydraulic drive system for a heavy-load mobile manipulator is usually operated under single mode, such that both inlet/outlet and potential energy losses are large to lower the energy efficiency. In this paper, a novel electro-hydraulic drive system is presented to improve energy efficiency. Extended control degrees of freedom are obtained utilizing the independent metering valve and electronic controlled pump. Then, multiple operating modes are carried out pertaining to the cylinder, valve, and pump. To achieve both optimal energy efficiency and precise motion tracking, both multi-mode switching and multi-variable controller are designed to accommodate with time-varying and uncertain load characteristics. As a consequence, the inlet, outlet, and potential energy losses can be decreased simultaneously. The experimental validation is conducted by using a three-joint manipulator in a 2 t excavator. A duty cycle of movement including all three actuators and covering full load quadrants is used to evaluate the efficiency improvement. Compared with the conventional load sensing system, the proposed multi-mode switching system using the pump pressure with valve meter-in control mode yields a 25.8% energy-saving ratio. Furthermore, the pump flow with valve mete-out control mode yields a 35.3% energy-saving ratio. Using this combined control mode, higher efficiency can be obtained due to the minimum inlet losses, but faster dynamic response together with higher overshoot will appear. It is proved that the energy efficiency is improved, while the motion tracking performance is not degraded by introducing the multi-mode switching