Patient characteristics.

<p>Abbreviations: HR, hormone receptor; IQR, interquartile range; HOMA-IR, homeostasis model assessment for insulin resistance; BMI, body mass index; CTx, chemotherapy; HRT, hormone therapy.</p

Adjusted hazard ratios of PGRN quartile levels for breast cancer recurrence.

<p>Adjusted for age, BMI, tumor size (<2 cm or ≥2 cm), lymph node metastasis (*HR-positive group only), adjuvant chemotherapy (yes or no), adiponectin, HOMA-IR and estradiol.</p><p>Abbreviations: HR, hormone receptor; LN, lymph node; Q, quartile.</p

Kaplan-Meier curves of survival from brain metastasis according to HER2 status and receipt of trastuzumab

<p><b>Copyright information:</b></p><p>Taken from "Breast cancer subtypes and survival in patients with brain metastases"</p><p>http://breast-cancer-research.com/content/10/1/R20</p><p>Breast Cancer Research : BCR 2008;10(1):R20-R20.</p><p>Published online 28 Feb 2008</p><p>PMCID:PMC2374976.</p><p></p

Schematic diagrams of the location of the seven SNPs in IGF1R and strength of the pairwise-linkage disequilibrium (LD) between SNPs.

<p>Strengths of the LD between SNPs were indicated by the color scheme, measured using a combination of the statistic D’ and the LOD score.</p

Analysis of the association between IGF1R gene under additive model and the risk of breast cancer.

<p>OR (CI 95%)¹: Multivariate logistic regression model. Adjusted for age at diagnosis, BMI, age at menarche, and age at first parturition.</p><p>² Tests for trend were conducted by coding for the number of variant alleles and reporting the <i>p</i>-value from models based on logistic regression analyses.</p

Haplotype analysis of the association between IGF1R under three genetic models and the risk of breast cancer.

<p>Percentage of genotype among group.</p><p>OR (CI95%)¹: Univariate logistic regression model.</p><p>OR (CI95%)²: Multivariate logistic regression model. Adjusted for age at diagnosis, BMI, age at menarche, and age at first parturition.</p><p>^a Breast cancer risk for heterozygotes (AB) and homozygotes (BB), each compared with major allele homozygotes (AA) in model adjusted genotyping.</p><p>^b Breast cancer risk for minor allele carriers (AB/BB) compared with major allele homozygotes (AA) in model adjusted for genotyping.</p><p>^c Breast cancer risk for minor allele homozygotes (BB) compared with major allele carriers (AA/AB) in model adjusted for genotyping.</p><p>SNPs’ location on chromosome number.</p

IGF1R allele frequencies and genotype distribution in breast cancer controls and cases.

<p>Frequency of alleles among total genotyped subjects.</p

Multivariate analysis of time-to-progression and overall survival.

<p>HR: hormone receptor.</p

Kaplan-Meier curves of overall survival according to HER2 (A), p95HER2 (B), HER3 (C), and HER2/HER3 (D) level.

<p><i>P</i>-values by log-rank test.</p

Multivariate analysis of CPCC or MAI for correlation with RFS using Cox proportional hazard regression model at two institutions.

<p>The co-variables of age at diagnosis (groups 1–5), T stage (T1, T2 or T3), N stage (N0, N1, N2 or N3), HER2 status (negative or positive), ER status (negative or positive), PR status (negative or positive), institution (KCCH or IIPH), and year of surgical resection (2000, 2001, 2002, 2003, 2005, or 2006) were used in the multivariate analysis, treating each co-variable as a categorical variable.</p>†<p><i>P</i> for linear trend.</p><p>KCCH  =  Korean Cancer Center Hospital; IIPH  =  Ilsan Inje Paik Hospital; CI  =  confidence interval.</p