The Benue-Gongola-Chad Basin : zone of ethnic and linguistic compression

We wish to emphasize the fact that so far our investigations have concentrated on documenting large bodies of data covering a number of linguistic units in an area which - as we hope to have demonstrated - displays a highly complex linguistic and ethnic structure. Our aim in the above remarks is essentially to throw out a challenge. In order to be able to interpret this situation in terms of the historic development of this zone of compression, further investigations are required, particularly regarding linguistic interference between Chadic and Niger-Congo languages in the south, as well as between Chadic and Nilo-Saharan languages, particularly Kanuri in the north-east and Songhay in the north-west. Ultimately, questions like the following are at stake: To what extent did the numerous Chadic languages preserve their original Hamitosemitic heritage? What is the impact of the Niger-Congo and Nilo-Saharan languages on individual Chadic languages in the respective border areas? In this context, detailed comparative studies between Chadic and Adamawa on the one hand, Chadic and Jukunoid and Chadic and Jarawan Bantu on the other hand as well as Chadic internal research, are urgently required

Erosive Prozesse in der Tangale-Sprache

Die Faktoren, die das Gefüge und den Aufbau eines Satzes bestimmen, sind möglicherweise schwerer zu definieren als die die Landschaft bestimmenden Geofaktoren. Verkürzt gesagt, richten sich die verschiedenen Satztypen nach den mannigfaltigen Intentionen, die der Sprecher mit seiner Aussage verbindet. Die Mittel, die die einzelne Sprache zum Ausdruck dieser vielfältigen Intentionen beim Aufbau und bei der materiellen Ausstattung eines Satzes zur Anwendung bringt, müssen etwas mit dem je spezifischen "Geist" einer Sprache zu tun haben; sie bestimmen letztendlich den Charakter einer Sprache. Ob sie im Geiste einer großen Redundanz und Explizität auf den Plan treten und zur Wirkung kommen oder ob äußerste Sparsamkeit, Kargheit und Ökonomie das äußere Bild eines Satzes prägen, dürfte unter anderem von zwei Grundfaktoren abhängen) vom geschichtlichen Schicksal der betreffenden Sprachgemeinschaft, d.h. von ihrer kulturellen Entwicklung, den inneren Prozessen und äußeren Kontakten und Einflüssen, denen sie im Laufe der Jahrhunderte und -tausende unterworfen war, und von dem geistigen Charakter und Format der Sprechergemeinschaft. Zur praktischen Demonstration des hier Gemeinten bietet sich aus mehreren Gründen die Sprache der Tangale im Raume südlich von Gombe an

Novel Strategies for Endothelial Preservation in Lung Transplant Ischemia-Reperfusion Injury

Lung ischemia reperfusion (IR) injury inevitably occurs during lung transplantation. The pulmonary endothelium is the primary target of IR injury that potentially results in severe pulmonary dysfunction. Over the last decades, various molecules, receptors, and signaling pathways were identified in order to develop treatment strategies for the preservation of the pulmonary endothelium against IR injury. We here review the latest and most promising therapeutic strategies for the protection of the endothelium against IR injury. These include the stabilization of the endothelial glycocalyx, inhibition of endothelial autophagy, inhibition of adhesion molecules, targeting of angiotensin-converting enzyme, and traditional viral and novel non-viral gene transfer approaches. Though some of these strategies proved to be promising in experimental studies, very few of these treatment concepts made the transfer into clinical application. This dilemma underscores the need for more experimental evidence for the translation into clinical studies to invent therapeutic concepts against IR injury-mediated endothelial damage

Primary Sclerosing Epithelioid Fibrosarcoma of the Lung in a Patient with Lynch Syndrome

Sclerosing epithelioid fibrosarcoma (SEF) is a rare neoplasm arising mostly in limbs and limb girdles, with a high rate of recurrence and a strong tendency to metastasize. This case study is of a 54-year-old woman with an asymptomatic mass in the upper lobe of the left lung detected by PET-CT when staging for Lynch syndrome-associated colon carcinoma. Histology of the resected tumor showed epithelioid cells arranged in nests, partly restiform within a zone of sclerosing fibrosis. Immunohistochemistry was positive for vimentin, epithelial membrane antigen, and S100-protein. Eight months after lung resection, the patient was diagnosed for basal cell carcinoma on her back. At the end of a twoyear follow-up period, she developed metastases to the mediastinum, vertebrae, ribs, femurs, pelvic bones, kidneys, and one lung, histologically all related to SEF. Here we report the first case of a SEF primarily arising from the lung and discuss it in the context of the current literatur

Préliminaires à une étude du saba, langue tchadique orientale du Tchad (région de Melfi)

The article provides first information on Saba, an Eastern Chadic minority language spoken in the Melfi district of the Guéra region, northeast of Melfi by some 1,500 speakers. The main focus is on the grammatical structures of the verb, which are based on a binary aspect system, i.e. a perfective – imperfective distinction. A considerable percentage of verbs are “strong” in that they display internal ablaut, e.g. the verb meaning ‘to kill’: perfective: dèegè (past), imperfective: díggà (present) and dàagà (future). According to the different vocalic patterns, seven classes of strong verbs may be distinguished. Phonologically, Saba belongs to the rather small group of Chadic languages which display two centralized vowel phonemes, i.e. ə and ʌ.L'article fournit les premières informations sur le saba, une langue minoritaire tchadique de l’Est, parlée par environ 1500 locuteurs dans le district de Melfi, région du Guéra, au Nord-Est de Melfi. L'accent principal est mis sur les structures grammaticales du verbe, qui sont basées sur un système aspectuel binaire, c'est-à-dire avec une opposition perfectif-imperfectif. Un pourcentage considérable de verbes sont «forts» dans la mesure où ils affichent des alternances vocaliques internes, par exemple le verbe signifiant «tuer»: perfectif: dèegè (passé), imperfectif: díggà (présent) et dàagà (futur). Selon les différents systèmes vocaliques, sept classes de verbes forts peuvent être distinguées. Phonologiquement, le Saba appartient plutôt au petit groupe de langues tchadiques ayant deux phonèmes vocaliques centralisés, c'est-à-dire ə et ʌ

In memoriam Alexander Neil Skinner 13. November 1921 – 7. März 2015

Obituary for Alexander Neil Skinner

CD26/DPP-4 inhibition recruits regenerative stem cells via stromal cell-derived factor-1 and beneficially influences ischaemia-reperfusion injury in mouse lung transplantation†

OBJECTIVES The CD26 antigen is a transmembrane glycoprotein that is constitutively expressed on activated lymphocytes and in pulmonary parenchyma. This molecule is also identified as dipeptidyl peptidase-4 (DPP-4) that cleaves a host of biologically active peptides. Here, we aimed to identify an important substrate of CD26/DPP-4—stromal cell-derived factor-1 (SDF-1/CXCL12)—as a key modulator for stem-cell homing together with its receptor CXCR4 in response to ischaemic injury of the lung. METHODS Orthotopic single lung transplantation (Tx) was performed between syngeneic C57BL/6 mice. Inhibition of CD26/DPP-4 activity in recipients was achieved using vildagliptin (10mg/kg, every 12h) subcutaneously, and 6h ischaemia time was applied prior to implantation. Forty-eight hours after Tx, lung histology, SDF-1 levels (enzyme-linked immunosorbent assay) in lung, spleen and plasma, and expression of the SDF-1 receptor CXCR4 in blood and lung were assessed. Homing of regenerative progenitor cells to the transplanted lung was evaluated using fluorescent-activated cell sorting. RESULTS Compared with untreated lung transplanted mice, systemic DPP-4 inhibition of Tx recipients resulted in an increase in protein concentration of SDF-1 in plasma, spleen and lung. Concordantly, the frequency of cells bearing the SDF-1 receptor CXCR4 rose significantly in the circulation and also in the lungs of DPP-4-inhibited recipients. We found co-expression of CXCR4/CD34 in the grafts of animals treated with vildagliptin, and the stem-cell markers Flt-3 and c-kit were present on a significantly increased number of cells. The morphology of grafts from DPP-4 inhibitor-treated recipients revealed less alveolar oedema when compared with untreated recipients. CONCLUSIONS Targeting the SDF-1-CXCR4 axis through CD26/DPP-4 inhibition increased the intragraft number of progenitor cells contributing to the recovery from ischaemia-reperfusion lung injury. Stabilization of endogenous SDF-1 is achievable and may be a promising strategy to intensify sequestration of regenerative stem cells and thus emerges as a novel therapeutic concep

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and colonize target organs. Here, we examined the role of interleukin (IL)-22 in metastasis. Immune cell-derived IL-22 acts on epithelial tissues, promoting regeneration and healing upon tissue damage, but it is also associated with malignancy. Il22-deficient mice and mice treated with an IL-22 antibody were protected from colon-cancer-derived liver and lung metastasis formation, while overexpression of IL-22 promoted metastasis. Mechanistically, IL-22 acted on endothelial cells, promoting endothelial permeability and cancer cell transmigration via induction of endothelial aminopeptidase N. Multi-parameter flow cytometry and single-cell sequencing of immune cells isolated during cancer cell extravasation into the liver revealed iNKT17 cells as source of IL-22. iNKT-cell-deficient mice exhibited reduced metastases, which was reversed by injection of wild type, but not Il22-deficient, invariant natural killer T (iNKT) cells. IL-22-producing iNKT cells promoting metastasis were tissue resident, as demonstrated by parabiosis. Thus, IL-22 may present a therapeutic target for prevention of metastasis

The depletion of donor macrophages reduces ischaemia-reperfusion injury after mouse lung transplantation†

OBJECTIVES Macrophages (M) are one of the most important cells of the innate immune system for first line defense. Upon transplantation (Tx), M play a prominent role during lung ischaemia reperfusion (I/R) injury. Here, we hypothesize that the depletion of donor M ameliorates the post-transplant lung I/R injury. METHODS Orthotopic single-lung Tx was performed between syngeneic BALB/c mice after a cold ischaemic time of 8 h and a reperfusion time of 10 h. Prior to graft implantation, alveolar macrophages of donor lungs were selectively depleted applying the ‘suicide technique' by intratracheal application of clodronate liposomes (experimental, n = 6) vs the application of empty liposomes (control, n = 6). Cell count (number of F4/80+-macrophages) and graft injury were evaluated by histology and immunohistochemistry, and levels of lactat dehydrogenase (LDH) (apoptosis assay), enzyme linked immunosorbent assay for nuclear protein high-mobility-group-protein B1 (HMGB1), tumor necrosis factor alpha (TNF-α) and transforming growth factor beta1 (TGF-β1) in plasma were analysed. RESULTS Clodronate liposomes successfully reduced 70% of M from donor lungs when compared with grafts treated with empty liposome only. M-depleted transplants showed improved histology and revealed considerably less graft damage when compared with control recipients (LDH, P = 0.03; HMGB1, P = 0.3). Oxygenation capacity was ameliorated in M-depleted transplants, if not significant (P = 0.114); however, wet/dry ratio did not differ between groups (P = 0.629). The inflammatory response was significantly reduced in M-depleted mice when compared with control recipients (TNF-α, P = 0.042; TGF-β1, P = 0.039). CONCLUSIONS The selective depletion of M in donor lung transplants can be successfully performed and results in a sustained anti-inflammatory response upon I/R-injury. The beneficial effect of this preconditioning method should be further evaluated as a promising tool for the attenuation of I/R prior to graft implantation in clinical T

Independent risk factors for an increased incidence of thromboembolism after lung transplantation.

BACKGROUND Thromboembolism (TE) after lung transplantation (LTX) is associated with increased morbidity and mortality. The aim of this study is to analyze the incidence and outcome of venous and arterial thromboembolic complications and to identify independent risk factors. PATIENTS AND METHODS We retrospectively analyzed the medical records of 221 patients who underwent LTX at our institution between 2002 and 2021. Statistical analysis was performed using SPSS and GraphPad software. RESULTS 74 LTX recipients (33%) developed TE. The 30-days incidence and 12-months incidence were 12% and 23%, respectively. Nearly half of the patients (48%) developed pulmonary embolism, 10% ischemic stroke. Arterial hypertension (p = 0.006), a body mass index (BMI) > 30 (p = 0.006) and diabetes mellitus (p = 0.041) were independent predictors for TE. Moreover, a BMI of > 25 at the time of transplantation was associated with an increased risk for TE (43% vs. 32%, p = 0.035). At the time of LTX, 65% of the patients were older than 55 years. An age > 55 years also correlated with the incidence of TE (p = 0.037) and these patients had reduced overall post-transplant survival when the event occurred within the first postoperative year (59% vs. 72%, p = 0.028). CONCLUSIONS The incidence of TE after LTX is high, especially in lung transplant recipients with a BMI > 25 and an age > 55 years as well as cardiovascular risk factors closely associated with the metabolic syndrome. As these patients comprise a growing recipient fraction, intensified research should focus on the risks and benefits of regular screening or a prolonged TE prophylaxis in these patients. Trial registration number DKRS: 00021501