Nitrogen-Doped Partially Reduced Graphene Oxide Rewritable Nonvolatile Memory

As memory materials, two-dimensional (2D) carbon materials such as graphene oxide (GO)-based materials have attracted attention due to a variety of advantageous attributes, including their solution-processability and their potential for highly scalable device fabrication for transistor-based memory and cross-bar memory arrays. In spite of this, the use of GO-based materials has been limited, primarily due to uncontrollable oxygen functional groups. To induce the stable memory effect by ionic charges of a negatively charged carboxylic acid group of partially reduced graphene oxide (PrGO), a positively charged pyridinium N that served as a counterion to the negatively charged carboxylic acid was carefully introduced on the PrGO framework. Partially reduced N-doped graphene oxide (PrGO_DMF) in dimethylformamide (DMF) behaved as a semiconducting nonvolatile memory material. Its optical energy band gap was 1.7–2.1 eV and contained a sp² CC framework with 45–50% oxygen-functionalized carbon density and 3% doped nitrogen atoms. In particular, rewritable nonvolatile memory characteristics were dependent on the proportion of pyridinum N, and as the proportion of pyridinium N atom decreased, the PrGO_DMF film lost memory behavior. Polarization of charged PrGO_DMF containing pyridinium N and carboxylic acid under an electric field produced N-doped PrGO_DMF memory effects that followed voltage-driven rewrite-read-erase-read processes

DataSheet_1_Insights into saline adaptation strategies through a novel halophilic bacterium isolated from solar saltern of Yellow sea.docx

Solar salterns were placed along the coast and were frequently left unattended after use. While many studies have isolated and identified microorganisms from hypersaline environments, their role and adaptation mechanisms are still unclear. Herein, we elucidated the role of halophiles in salt-polluted areas through the recently reported Halomonas getboli YJPS3-2 from the abandoned saltern. We analyzed the expression levels of genes in the YJPS3-2 strain to identify its adaptation mechanisms to high salinity environments, by representing the process from tidal flats to abandoned salterns with varying salinity gradients. The YJPS3-2 strain primarily overexpresses genes associated with ABC transport to adapt to hypersaline environments. Interestingly, the cheA gene, which recognizes changes in the surrounding, was the most upregulated, and it was also associated with the overexpression of the MS ring and T3SS mechanisms relating to the flagellar activity. The YJPS3-2 recognized the high salt concentration in its surroundings and attempted to accumulate compatible solutes that could withstand high osmotic pressure inside the cell to adapt to the high salinity environment. Furthermore, during this process, the YJPS3-2 strain removed surrounding pollutants and secreted secondary metabolites that could be utilized by neighboring organisms. Our results suggested that this halophilic bacterium has the potential to serve as a pioneering species for thriving the surrounding while adapting to saline environments.</p

Structure–Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains

To better understand the contribution of methyl-lysine (Kme) binding proteins to various disease states, we recently developed and reported the discovery of <b>1</b> (UNC3866), a chemical probe that targets two families of Kme binding proteins, CBX and CDY chromodomains, with selectivity for CBX4 and -7. The discovery of <b>1</b> was enabled in part by the use of molecular dynamics simulations performed with CBX7 and its endogenous substrate. Herein, we describe the design, synthesis, and structure–activity relationship studies that led to the development of <b>1</b> and provide support for our model of CBX7–ligand recognition by examining the binding kinetics of our antagonists with CBX7 as determined by surface-plasmon resonance