Convolution layer with nonlinear kernel of square of subtraction for dark-direction-free recognition of images

A nonlinear kernel with a bias is proposed here in the convolutional neural network. Negative square of subtraction between input image pixel numbers and the kernel coefficients are convolved to conform new feature map through the convolution layer in convolutional neural network. The operation is nonlinear from the input pixel point of view, as well as from the kernel weight coefficient point of view. Maximum-pooling may follow the feature map, and the results are finally fully connected to the output nodes of the network. While using gradient descent method to train relevant coefficients and biases, the gradient of the square of subtraction term appears in the whole gradient over each kernel coefficient. The new subtraction kernel is applied to two sets of images, and shows better performance than the existing linear convolution kernel. Each coefficient of the nonlinear subtraction kernel has quite image-equivalent meaning on top of pure mathematical number. The subtraction kernel works equally for a given black and white image set and its reversed version or for a given gray image set and its reversed version. This attribute becomes important when patterns are mixed with light color and dark color, or mixed with background color, and still both sides are equally important

A Novel Incisionless Disposable Vaginal Device for Female Stress Urinary Incontinence: Efficacy and Quality of Life

Purpose This clinical study sought to evaluate the possible clinical effectiveness and practicality of URINO, an innovative, incisionless, and disposable intravaginal device, designed for patients suffering from stress urinary incontinence. Methods A prospective, multicenter, single-arm clinical trial was carried out, involving women diagnosed with stress urinary incontinence who used a self-inserted, disposable intravaginal pessary device. Comparisons were made between the results of the 20-minute pad-weight gain (PWG) test at baseline and visit 3, where the device was applied. After 1 week of device usage, compliance, satisfaction, the sensation of a foreign body, and adverse events were assessed. Results Out of 45 participants, 39 completed the trial and expressed satisfaction within the modified intention-to-treat group. The average 20-minute PWG of participants was 17.2±33.6 g at baseline and significantly dropped to 5.3±16.2 g at visit 3 with device application. A total of 87.2% of participants exhibited a reduction ratio of PWG by 50% or more, surpassing the clinical trial success benchmark of 76%. The mean compliance was recorded as 76.6%±26.6%, the average visual analogue scale score for patient satisfaction was 6.4±2.6, and the sensation of a foreign body, measured on a 5-point Likert scale, was 3.1±1.2 after 1 week of device use. No serious adverse events were reported; there was 1 instance of microscopic hematuria and 2 cases of pyuria, all of which recovered. Conclusions The investigated device demonstrated significant clinical effectiveness and safety for patients with stress urinary incontinence. It was easy to use, showing favorable patient compliance. We propose that these disposable intravaginal pessaries could potentially be an alternative treatment for patients with stress urinary incontinence who are seeking nonsurgical options or are unable to undergo surgery. Trial Registration The study was registered as a clinical trial (KCT0008369)

Original Article Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells

Abstract: STAT3 has been recognized as an efficacious drug target for prostate cancer because of its constitutive activation in this fatal disease. We recently identified the root bark of Morus alba Linn. as a potential STAT3 inhibitor among 33 phytomedicines traditionally used in Korea. Morusin, an active compound isolated from the root bark of Morus alba, has shown anti-oxidant and anti-inflammatory effects. In the present study, we examined whether morusin has a potential as an anti-cancer agent in prostate cancer. We found that morusin suppressed viability of prostate cancer cells, but little effect in normal human prostate epithelial cells. Morusin also reduced STAT3 activity by inhibiting its phosphorylation, nuclear accumulation, and DNA binding activity. In addition, morusin down-regulated expression of STAT3 target genes encoding Bcl-xL, Bcl-2, Survivin, c-Myc and Cyclin D1, which are involved in regulation of apoptosis and cell cycle. Furthermore, morusin induced apoptosis in human prostate cancer cells by reducing STAT3 activity. Taken together, these results suggest that morusin could be a potentially therapeutic agent for prostate cancer by reducing STAT3 activity and inducing apoptosis

Nanostring-based multigene assay to predict recurrence for gastric cancer patients after surgery

10.1371/journal.pone.0090133PLoS ONE93-POLN

Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations.

Methylation profiling based on bead-chip arrays is an effective method for screening aberrantly methylated genes in CRC. In addition, we identified novel methylated genes that are candidate diagnostic or prognostic markers for CRC

Simulation of Bay-Shaped Shorelines after the Construction of Large-Scale Structures by Using a Parabolic Bay Shape Equation

Among the various causes of coastal erosion, the installation of offshore breakwaters is considered the main cause that influences the most serious changes in shorelines. However, without a proper means for predicting such terrain changes, countries and regions continue to suffer from the aftermath of development projects on coastal land. It has been confirmed that the parabolic bay shape equation (PBSE) can accurately predict shoreline changes under the wave climate diffracted as a result of such development projects. This study developed a shoreline change model that has enhanced the previous shoreline change models by applying PBSE to shoreline changes into bay-shaped features. As an analytical comparison with the second term of the GENESIS model, which is an existing and well-known shoreline change model, a similar beach erosion width was obtained for a small beach slope. However, as the beach slope became larger, the result became smaller than that of the GENESIS model. The validity of the model was verified by applying it to satellite images that demonstrated the occurrence of shoreline changes caused by breakwaters for seaports on the eastern coast of Korea; Wonpyeong beach, Yeongrang beach, and Wolcheon beach. As a result, each studied site converged on the static equilibrium planform within several years. Simultaneously, the model enabled the coastal management of the arrangement of seaports to evaluate how the construction of structures causes serious shoreline changes by creating changes to wavefields