Associations Between Conventional Healthy Behaviors and Social Distancing During the COVID-19 Pandemic: Evidence From the 2020 Community Health Survey in Korea

Objectives: Many studies have shown that social distancing, as a non-pharmaceutical intervention (NPI) that is one of the various measures against coronavirus disease 2019 (COVID-19), is an effective preventive measure to suppress the spread of infectious diseases. This study explored the relationships between traditional health-related behaviors in Korea and social distancing practices during the COVID-19 pandemic. Methods: Data were obtained from the 2020 Community Health Survey conducted by the Korea Disease Control and Prevention Agency (n=98 149). The dependent variable was the degree of social distancing practice to cope with the COVID-19 epidemic. Independent variables included health-risk behaviors and health-promoting behaviors. The moderators were vaccination and unmet medical needs. Predictors affecting the practice of social distancing were identified through hierarchical multiple logistic regression analysis. Results: Smokers (adjusted odds ratio [aOR], 0.924) and frequent drinkers (aOR, 0.933) were more likely not to practice social distancing. A greater degree of physical activity was associated with a higher likelihood of practicing social distancing (aOR, 1.029). People who were vaccinated against influenza were more likely to practice social distancing than those who were not (aOR, 1.150). However, people with unmet medical needs were less likely to practice social distancing than those who did not experience unmet medical needs (aOR, 0.757). Conclusions: Social distancing practices were related to traditional health behaviors such as smoking, drinking, and physical activity. Their patterns showed a clustering effect of health inequality. Therefore, when establishing a strategy to strengthen social distancing, a strategy to protect the vulnerable should be considered concomitantly

Alpha-tocopherol exerts protective function against the mucotoxicity of particulate matter in amphibian and human goblet cells

Exposure to particulate matter (PM) in ambient air is known to increase the risk of cardiovascular disorders and mortality. The cytotoxicity of PM is mainly due to the abnormal increase of reactive oxygen species (ROS), which damage cellular components such as DNA, RNA, and proteins. The correlation between PM exposure and human disorders, including mortality, is based on long-term exposure. In this study we have investigated acute responses of mucus-secreting goblet cells upon exposure to PM derived from a heavy diesel engine. To this end, we employed the mucociliary epithelium of amphibian embryos and human Calu-3 cells to examine PM mucotoxicity. Our data suggest that acute exposure to PM significantly impairs mucus secretion and results in the accumulation of mucus vesicles in the cytoplasm of goblet cells. RNA-seq analysis revealed that acute responses to PM exposure significantly altered gene expression patterns; however, known regulators of mucus production and the secretory pathway were not significantly altered. Interestingly, pretreatment with alpha-tocopherol nearly recovered the hyposecretion of mucus from both amphibian and human goblet cells. We believe this study demonstrates the mucotoxicity of PM and the protective function of alpha-tocopherol on mucotoxicity caused by acute PM exposure from heavy diesel engines

Model eye imaging by closed-loop accumulation of single scattering (CLASS) microscopy

‘Closed-loop accumulation of single scattering (CLASS)’ microscopy provides novel solutions to the problems of light scattering and aberration in optical imaging, providing increased imaging depth while maintaining diffraction limited resolution. This method has a great potential to increase imaging depth and resolution of current eye imaging. In this presentation, the strength and weakness of the CLASS microscopy over the current adaptive optical microscopy will be discussed. Important factors to apply CLASS microscopy to eye imaging and the possibility to imaging retina in turbid condition will be discussed by using model eye

Universal convex covering problems under translation and discrete rotations

We consider the smallest-area universal covering of planar objects of perimeter 2 (or equivalently closed curves of length 2) allowing translation and discrete rotations. In particular, we show that the solution is an equilateral triangle of height 1 when translation and discrete rotation of $\pi$ are allowed. Our proof is purely geometric and elementary. We also give convex coverings of closed curves of length 2 under translation and discrete rotations of multiples of $\pi/2$ and $2\pi/3$. We show a minimality of the covering for discrete rotation of multiples of $\pi/2$, which is an equilateral triangle of height smaller than 1, and conjecture that the covering is the smallest-area convex covering. Finally, we give the smallest-area convex coverings of all unit segments under translation and discrete rotations $2\pi/k$ for all integers $k\ge 3$

Mutagenic activity of river water from a river near textile industrial complex in Korea

The mutagenic activity of XAD-2 adsorbates and water extracts recovered from nine locations of the Kumho River was tested on S. typhimurium TA98 strain to identify the source of the mutagenicity. A sampling site, receiving effluents from the textile industrial complex located in Daegu City, showed extraordinarily high mutagenic activity, especially in the presence of S9 mixture, at all sampling time in both XAD-2 adsorbates and dichloromethane extracts. This indicated the existence of the frame-shift mutagens in the Kumho River, same type of mutagens detected in previous studies by other researchers in the Nakdong River into which the Kumho River discharges. The fractionation study showed that the mutagenic chemicals in the river water are mid-polar. Furthermore, mean tail length obtained by single cell gel electrophoresis assay (Comet assay) showed consistent dose-dependent DNA damage, indicating that the chemicals in the river water not only act as frame-shift mutagens but also break human lymphocytes DNA strain. Chemical identification of the mutagens should be require

SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC

The role of Sirtuin 6 (SIRT6) as a tumor suppressor or oncogene in liver cancer remains controversial. Thus, we identified the specific role of SIRT6 in the progression of hepatocellular carcinoma (HCC). SIRT6 expression was significantly higher in HCC cell lines and HCC tissues from 138 patients than in an immortalized hepatocyte cell line, THLE-2 and non-tumor tissues, respectively. SIRT6 knockdown by shRNA suppressed the growth of HCC cells and inhibited HCC tumor growth in vivo. In addition, SIRT6 silencing significantly prevented the growth of HCC cell lines by inducing cellular senescence in the p16/Rb- and p53/p21-pathway independent manners. Microarray analysis revealed that the expression of genes involved in nucleosome assembly was apparently altered in SIRT6-depleted Hep3B cells. SIRT6 knockdown promoted G2/M phase arrest and downregulation of genes encoding histone variants associated with nucleosome assembly, which could be attributed to DNA damage. Taken together, our findings suggest that SIRT6 acts as a tumor promoter by preventing DNA damage and cellular senescence, indicating that SIRT6 represents a potential therapeutic target for the treatment of HCC.11137Ysciescopu

High-resolution embedding extractor for speaker diarisation

Speaker embedding extractors significantly influence the performance of clustering-based speaker diarisation systems. Conventionally, only one embedding is extracted from each speech segment. However, because of the sliding window approach, a segment easily includes two or more speakers owing to speaker change points. This study proposes a novel embedding extractor architecture, referred to as a high-resolution embedding extractor (HEE), which extracts multiple high-resolution embeddings from each speech segment. Hee consists of a feature-map extractor and an enhancer, where the enhancer with the self-attention mechanism is the key to success. The enhancer of HEE replaces the aggregation process; instead of a global pooling layer, the enhancer combines relative information to each frame via attention leveraging the global context. Extracted dense frame-level embeddings can each represent a speaker. Thus, multiple speakers can be represented by different frame-level features in each segment. We also propose an artificially generating mixture data training framework to train the proposed HEE. Through experiments on five evaluation sets, including four public datasets, the proposed HEE demonstrates at least 10% improvement on each evaluation set, except for one dataset, which we analyse that rapid speaker changes less exist.Comment: 5pages, 2 figure, 3 tables, submitted to ICASS

Absolute decision corrupts absolutely: conservative online speaker diarisation

Our focus lies in developing an online speaker diarisation framework which demonstrates robust performance across diverse domains. In online speaker diarisation, outputs generated in real-time are irreversible, and a few misjudgements in the early phase of an input session can lead to catastrophic results. We hypothesise that cautiously increasing the number of estimated speakers is of paramount importance among many other factors. Thus, our proposed framework includes decreasing the number of speakers by one when the system judges that an increase in the past was faulty. We also adopt dual buffers, checkpoints and centroids, where checkpoints are combined with silhouette coefficients to estimate the number of speakers and centroids represent speakers. Again, we believe that more than one centroid can be generated from one speaker. Thus we design a clustering-based label matching technique to assign labels in real-time. The resulting system is lightweight yet surprisingly effective. The system demonstrates state-of-the-art performance on DIHARD 2 and 3 datasets, where it is also competitive in AMI and VoxConverse test sets.Comment: 5pages, 2 figure, 4 tables, submitted to ICASS