2 research outputs found
2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy
One
of the clinical challenges facing photothermal cancer therapy is health
risks imposed by the photothermal nanoagents in vivo. Herein, a photothermal
therapy (PTT) platform composed of a 2D material-based nanofibrous
membrane as the agent to deliver thermal energy to tumors under near-infrared
(NIR) light irradiation is described. The photothermal membrane, which
is fabricated by an electrospinning polyÂ(l-lactic acid) (PLLA)
nanofibrous membrane loaded with bismuth selenide (Bi<sub>2</sub>Se<sub>3</sub>) nanoplates, exhibits very high photothermal conversion efficiency
and long-term stability. Cell experiments and hematological analyses
demonstrate that the Bi<sub>2</sub>Se<sub>3</sub>/PLLA membranes have
excellent biocompatibility and low toxicity. PTT experiments performed
in vivo with the Bi<sub>2</sub>Se<sub>3</sub>/PLLA membrane covering
the tumor and NIR irradiation produce local hyperthermia to ablate
the tumor with high efficiency. Different from the traditional systematical
and local injection techniques, this membrane-based PTT platform is
promising in photothermal cancer therapy, especially suitable for
the treatment of multiple solid tumors or skin cancers, and long-term
prevention of cancer recurrence after surgery or PTT, while eliminating
the health hazards of nanoagents
PLLA Nanofibrous Paper-Based Plasmonic Substrate with Tailored Hydrophilicity for Focusing SERS Detection
We
report a new paper-based surface enhanced Raman scattering (SERS)
substrate platform contributed by a polyÂ(l-lactic acid) (PLLA)
nanofibrous paper adsorbed with plasmonic nanostructures, which can
circumvent many challenges of the existing SERS substrates. This PLLA
nanofibrous paper has three-dimensional porous structure, extremely
clean surface with good hydrophobicity (contact angle is as high as
133.4°), and negligible background interference under Raman laser
excitation. Due to the strong electrostatic interaction between PLLA
nanofiber and cetyltrimethylammonium bromide (CTAB) molecules, the
CTAB-coated gold nanorods (GNRs) are efficiently immobilized onto
the fibers. Such a hydrophobic paper substrate with locally hydrophilic
SERS-active area can confine analyte molecules and prevent the random
spreading of molecules. The confinement leads to focusing effect and
the GNRs-PLLA SERS substrate is found to be highly sensitive (0.1
nM Rhodamine 6G and malachite green) and exhibit excellent reproducibility
(∼8% relative standard deviation (RSD)) and long-term stability.
Furthermore, it is also cost-efficient, with simple fabrication methodology,
and demonstrates high sample collection efficiency. All of these benefits
ensure that this GNRs-PLLA substrate is a really perfect choice for
a variety of SERS applications