3,3,5,5-Tetra­methyl-3,5-disila-4,10-dioxatetra­cyclo­[5.5.1.02,6.08,12]tridecane-9,11-dione

The title compound, C13H20O4Si2, is a siloxane-functionalized norbornane anhydride. Both five-membered heterocyclic rings of the mol­ecule have a planar structure, whereas the two five-membered aliphatic rings assume envelope conformations. Weak inter­molecular C—H⋯O hydrogen bonding is present in the crystal structure

Time-varying Reliability Analysis of Long-span Continuous Rigid Frame bridge under Cantilever Construction Stage based on the Monitored Strain Data

Abstract: In general, the material properties, loads, resistance of the prestressed concrete continuous rigid frame bridge in different construction stages are time-varying. So, it is essential to monitor the internal force state when the bridge is in construction. Among them, how to assess the safety is one of the challenges. As the continuous monitoring over a long-term period can increase the reliability of the assessment, so, based on a large number of monitored strain data collected from the structural health monitoring system (SHMS) during construction, a calculation method of the punctiform time-varying reliability is proposed in this paper to evaluate the stress state of this type bridge in cantilever construction stage by using the basic reliability theory. At the same time, the optimal stress distribution function in the bridge mid-span base plate is determined when the bridge is closed. This method can provide basis and direction for the internal force control of this type bridge in construction process. So, it can reduce the bridge safety and quality accidents in construction stages

SU(2)-in-SU(1,1) Nested Interferometer for Highly Sensitive, Loss-Tolerant Quantum Metrology

We present experimental and theoretical results on a new interferometer topology that nests a SU(2) interferometer, e.g., a Mach-Zehnder or Michelson interferometer, inside a SU(1,1) interferometer, i.e., a Mach-Zehnder interferometer with parametric amplifiers in place of beam splitters. This SU(2)-in-SU(1,1) nested interferometer (SISNI) simultaneously achieves high signal-to-noise ratio (SNR), sensitivity beyond the standard quantum limit (SQL) and tolerance to photon losses external to the interferometer, e.g., in detectors. We implement a SISNI using parametric amplification by four-wave mixing (FWM) in Rb vapor and a laser-fed Mach-Zehnder SU(2) interferometer. We observe path-length sensitivity with SNR 2.2 dB beyond the SQL at power levels (and thus SNR) 2 orders of magnitude beyond those of previous loss-tolerant interferometers. We find experimentally the optimal FWM gains and find agreement with a minimal quantum noise model for the FWM process. The results suggest ways to boost the in-practice sensitivity of high-power interferometers, e.g., gravitational wave interferometers, and may enable high-sensitivity, quantum-enhanced interferometry at wavelengths for which efficient detectors are not available.Comment: 6 pages + 4 of supplemental material, 5 figure

Bulleyaconitine A reduces fracture-induced pain and promotes fracture healing in mice

A fracture is a severe trauma that causes dramatic pain. Appropriate fracture pain management not only improves the patient’s subjective perception, but also increases compliance with rehabilitation training. However, current analgesics for fracture pain are unsatisfactory because of their negative effects on fracture healing or addiction problems. Bulleyaconitine A (BLA), a non-addictive analgesic medicine, is used for the treatment of chronic pain of musculoskeletal disorders in clinical practice, whereas the effects of BLA on fracture pain is undefined. To evaluate the analgesic effects of BLA on fracture, we generated tibial fracture mice here. It is found that oral administration of BLA to mice alleviates fracture-induced mechanical and thermal hyperalgesia. Interestingly, BLA significantly increases locomotor activity levels and reduces anxiety-like behaviors in fractured mice, as determined by open-field test. Notably, BLA treatment promotes bone mineralization and therefore fracture healing in mice, which may be attributed to the increase in mechanical stimulation caused by exercise. Our study suggests that BLA can be used as a promising analgesic agent for the treatment of fracture pain

Application on small incision extracapsular cataract extraction in large-scale vision recovery action in Shaanxi Province

AIM: To investigate the characteristics of scale cataract operations and the effects and experiences of small incision extracapsular cataract extraction with intraocular lens(IOL)implantation in large-scale vision recovery action. <p>METHODS: Four thousand eight hundred ninety-two cases(4 892 eyes)of cataract were treated by small incision non-phacoemulcification cataract extraction from March 2010 to November 2011 in our hospital(Fuming No.1 surgery car of Shaanxi Province)which were retrospectively analyzed. Visual acuity, intraoperative and postoperative complications, the recovery of postoperative inflammation were observed. <p>RESULTS: Visual acuity reached 0.3 or more in 4 521 eyes(92.42%)at 1d after the operation, at 3d after the operation in 4 571 eyes(93.44%), there were 4 887 eyes with IOL implantation, implantation rate was 99.90%. All the cases had lesser intraoperative and postoperative complications, and the postoperative inflammation recovered quickly. <p>CONCLUSION: Small incision extracapsular cataract extraction with IOL implantation is simple, effective, economical, safe and adapting for large-scale vision recovery action