Constraints and tests of the OPERA superluminal neutrinos

The superluminal neutrinos detected by OPERA indicates Lorentz invariance violation (LIV) of the neutrino sector at the order of $10^{-5}$. We study the implications of the result in this work. We find that such a large LIV implied by OPERA data will make the neutrino production process $\pi \to \mu + \nu_\mu$ kinematically forbidden for neutrino energy greater than about 5 GeV. The OPERA detection of neutrinos at 40 GeV can constrain the LIV parameter to be smaller than $3\times 10^{-7}$. Furthermore the neutrino decay in the LIV framework will modify the neutrino spectrum greatly. The atmospheric neutrino spectrum measured by IceCube can constrain the LIV parameter to the level of $10^{-12}$. The future detection of astrophysical neutrinos of Galactic sources is expected to be able to give even stronger constraint on the LIV parameter of neutrinos.Comment: 5 pages (2 column), 4 figures; published in Phys. Rev. Let

Electromagnetic-Circuital-Thermal-Mechanical Multiphysics Numerical Simulation Method For Microwave Circuits

An electromagnetic-circuital-thermal-mechanical Multiphysics numerical method is proposed for the simulation of microwave circuits. The discontinuous Galerkin time-domain (DGTD) method is adopted for electromagnetic simulation. The time-domain finite element method (FEM) is utilized for thermal simulation. The circuit equation is applied for circuit simulation. The mechanical simulation is also carried out by FEM method. A flexible and unified Multiphysics field coupling mechanism is constructed to cover various electromagnetic, circuital, thermal and mechanical Multiphysics coupling scenarios. Finally, three numerical examples emulating outer space environment, intense electromagnetic pulse (EMP) injection and high-power microwave (HPM) illumination are utilized to demonstrate the accuracy, efficiency, and capability of the proposed method. The proposed method provides a versatile and powerful tool for the design and analysis of microwave circuits characterized by intertwined electromagnetic, circuital, thermal and stress behaviors

Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance

Additional file 4: Table S3. Differential expressed lncRNAs identified in naked mole rat (Heterocephalus glaber) genome

Hypoxia-inducible factor-2a is associated with ABCG2 expression, histology-grade and Ki67 expression in breast invasive ductal carcinoma

<p>Abstract</p> <p>Background</p> <p>Breast cancer is the most common cancer and the leading cause of cancer mortality in women worldwide. Hypoxia is an important factor involved in the progression of solid tumors and has been associated with various indicators of tumor metabolism, angiogenesis and metastasis. But little is known about the contribution of Hypoxia-Inducible Factor-2a (HIF-2a) to the drug resistance and the clinicopathological characteristics in breast cancer.</p> <p>Methods</p> <p>Immunohistochemistry was employed on the tissue microarray paraffin sections of surgically removed samples from 196 invasive breast cancer patients with clinicopathological data. The correlations between the expression of HIF-2a and ABCG2 as well as other patients' clinicopathological data were investigated.</p> <p>Results</p> <p>The results showed that HIF-2a was expressed in different intensities and distributions in the tumor cells of the breast invasive ductal carcinoma. A positive staining for HIF-2a was defined as a brown staining observed mainly in the nucleus. A statistically significant correlation was demonstrated between HIF-2a expression and ABCG2 expression (p = 0.001), histology-grade (p = 0.029), and Ki67 (p = 0. 043) respectively.</p> <p>Conclusion</p> <p>HIF-2a was correlated with ABCG2 expression, histology-grade and Ki67 expression in breast invasive ductal carcinoma. HIF-2a could regulate ABCG2 in breast cancer cells, and could be a novel potential bio-marker to predict chemotherapy effectiveness. The hypoxia/HIF-2a/ABCG2 pathway could be a new mechanism of breast cancer multidrug-resistance.</p> <p>Virtual slides</p> <p>http://www.diagnosticpathology.diagnomx.eu/vs/2965948166714795</p