Arylsulfonyl Radical Triggered 1,6-Enyne Cyclization: Synthesis of γ‑Lactams Containing Alkenyl C–X Bonds

Cascade radical cyclization of 1,6-enynes for the synthesis of biologically important γ-lactams containing alkenyl C–X bonds is reported. In these radical cascade processes, three new chemical bonds, including C–S, C–C, and C–X bonds, are formed in one step. The method is attractive and valuable due to its mild reaction conditions, broad substrate scope, and the importance of the corresponding γ-lactam products

Construction of Polycyclic γ‑Lactams and Related Heterocycles via Electron Catalysis

Cascade radical cyclization of 1,6-enynes for the construction of biologically important polycyclic γ-lactams and related heterocycles is reported. In these radical cascade processes, three new C–C bonds are formed and transition metals are not required to run these sequences. The mild reaction conditions, broad substrate scope, and the importance of the heterocyclic products render the approach valuable

Construction of Polycyclic γ‑Lactams and Related Heterocycles via Electron Catalysis

Cascade radical cyclization of 1,6-enynes for the construction of biologically important polycyclic γ-lactams and related heterocycles is reported. In these radical cascade processes, three new C–C bonds are formed and transition metals are not required to run these sequences. The mild reaction conditions, broad substrate scope, and the importance of the heterocyclic products render the approach valuable

Silver(I)- and Base-Mediated [3 + 3]-Cycloaddition of <i>C</i>,<i>N</i>‑Cyclic Azomethine Imines with Aza-oxyallyl Cations

A silver­(I) and base-mediated [3 + 3]-cycloaddition reaction of in situ generated <i>C</i>,<i>N</i>-cyclic azomethine imines with in situ formed aza-oxyallyl cations is reported. This one-pot cycloaddition process shows broad substrate scope an excellent functional group tolerance and provides the corresponding biologically important isoquinoline-fused triazines in good to excellent yields

[3 + 2] Cycloaddition/Oxidative Aromatization Sequence via Photoredox Catalysis: One-Pot Synthesis of Oxazoles from 2<i>H</i>‑Azirines and Aldehydes

A novel [3 + 2] cycloaddition/oxidative aromatization sequence via visible light-induced photoredox catalysis is disclosed. It provides a general synthetic route to 2,4,5-trisubstituted oxazoles from easily accessible 2<i>H</i>-azirines and aldehydes under mild reaction conditions. The potential of this strategy was further demonstrated by the rapid synthesis of a cyclooxygenase-2 inhibitor as well as the success of employing electron-deficient alkenes and imines as the reaction partners

KO^<i>t</i>Bu-Promoted C4 Selective Coupling Reaction of Phenols and [60]Fullerene: One-Pot Synthesis of 4‑[60]Fullerephenols under Transition-Metal-Free Conditions

A KO^<i>t</i>Bu-promoted direct coupling reaction of phenols and [60]­fullerene was disclosed. The reaction occurs exclusively at the C4-position of phenols with high regioselectivity and provides an efficient and inexpensive manner to various 4-[60]­fullerephenols in good yields. The electrochemical properties of the products render the method attractive and valuable