1,236 research outputs found

    Latest Therapeutic Approaches Based on Cancer Stem Cells

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    Electric field thermopower modulation analyses of the operation mechanism of transparent amorphous SnO2_2 thin-film transistor

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    Transparent amorphous oxide semiconductors (TAOSs) based transparent thin-film transistors (TTFTs) with high field effect mobility are essential for developing advanced flat panel displays. Among TAOSs, amorphous (a-) SnO2_2 has several advantages against current a-InGaZnO4 such as higher field effect mobility and being indium free. Although a-SnO2_2 TTFT has been demonstrated several times, the operation mechanism has not been clarified thus far due to the strong gas sensing characteristics of SnO2_2. Here we clarify the operation mechanism of a-SnO2_2 TTFT by electric field thermopower modulation analyses. We prepared a bottom-gate top-contact type TTFT using 4.2-nm-thick a-SnO2_2 as the channel without any surface passivation. The effective thickness of the conducting channel was ~1.7 + - 0.4 nm in air and in vacuum, but a large threshold gate voltage shift occurred in different atmospheres; this is attributed to carrier depletion near at the top surface (~2.5 nm) of the a-SnO2_2 due to its interaction with the gas molecules and the resulting shift in the Fermi energy. The present results would provide a fundamental design concept to develop a-SnO2_2 TTFT

    SpreadCluster: Recovering Versioned Spreadsheets through Similarity-Based Clustering

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    Version information plays an important role in spreadsheet understanding, maintaining and quality improving. However, end users rarely use version control tools to document spreadsheet version information. Thus, the spreadsheet version information is missing, and different versions of a spreadsheet coexist as individual and similar spreadsheets. Existing approaches try to recover spreadsheet version information through clustering these similar spreadsheets based on spreadsheet filenames or related email conversation. However, the applicability and accuracy of existing clustering approaches are limited due to the necessary information (e.g., filenames and email conversation) is usually missing. We inspected the versioned spreadsheets in VEnron, which is extracted from the Enron Corporation. In VEnron, the different versions of a spreadsheet are clustered into an evolution group. We observed that the versioned spreadsheets in each evolution group exhibit certain common features (e.g., similar table headers and worksheet names). Based on this observation, we proposed an automatic clustering algorithm, SpreadCluster. SpreadCluster learns the criteria of features from the versioned spreadsheets in VEnron, and then automatically clusters spreadsheets with the similar features into the same evolution group. We applied SpreadCluster on all spreadsheets in the Enron corpus. The evaluation result shows that SpreadCluster could cluster spreadsheets with higher precision and recall rate than the filename-based approach used by VEnron. Based on the clustering result by SpreadCluster, we further created a new versioned spreadsheet corpus VEnron2, which is much bigger than VEnron. We also applied SpreadCluster on the other two spreadsheet corpora FUSE and EUSES. The results show that SpreadCluster can cluster the versioned spreadsheets in these two corpora with high precision.Comment: 12 pages, MSR 201

    New methods to measure residues coevolution in proteins

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    <p>Abstract</p> <p>Background</p> <p>The covariation of two sites in a protein is often used as the degree of their coevolution. To quantify the covariation many methods have been developed and most of them are based on residues position-specific frequencies by using the mutual information (MI) model.</p> <p>Results</p> <p>In the paper, we proposed several new measures to incorporate new biological constraints in quantifying the covariation. The first measure is the mutual information with the amino acid background distribution (MIB), which incorporates the amino acid background distribution into the marginal distribution of the MI model. The modification is made to remove the effect of amino acid evolutionary pressure in measuring covariation. The second measure is the mutual information of residues physicochemical properties (MIP), which is used to measure the covariation of physicochemical properties of two sites. The third measure called MIBP is proposed by applying residues physicochemical properties into the MIB model. Moreover, scores of our new measures are applied to a robust indicator <it>conn(k) </it>in finding the covariation signal of each site.</p> <p>Conclusions</p> <p>We find that incorporating amino acid background distribution is effective in removing the effect of evolutionary pressure of amino acids. Thus the MIB measure describes more biological background information for the coevolution of residues. Besides, our analysis also reveals that the covariation of physicochemical properties is a new aspect of coevolution information.</p
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