Multidimensional scaling based on the F_ST distances of eight indigenous populations from Mesoamerica and Aridoamerica (Stress = 0.097).

<p>Multidimensional scaling based on the F_ST distances of eight indigenous populations from Mesoamerica and Aridoamerica (Stress = 0.097).</p

Populations analyzed.

<p>Geographical distribution of populations analyzed (in bold) and those used for comparison purposes. Pie charts show haplogroup frequencies. Red lines indicate genetic barrier intensity and green lines the Monmonier geometric traces used to construct the barriers.</p

Theta estimators of eight indigenous populations from Mesoamerica and Aridoamerica.

<p>Theta estimators of eight indigenous populations from Mesoamerica and Aridoamerica.</p

AMOVAS based on different classification criteria.

*<p>Significance level 0.05.</p

Sequence diversity indices for mtDNA lineages in the control region (16024-576) in eight indigenous populations.

*<p>level of significance of 0.05.</p><p>N, sample size; K, number of different sequences; S, number of polymorphic sites; Ĥ, sequence diversity; π, nucleotide diversity; θ, mean number of pairwise differences between sequences; D, Tajima test of selective neutrality (sd represents the standard deviation).</p

Frequencies of <i>HLA-DRB1-DQB1</i> blocks in 234 Mexican admixed individuals (468 haplotypes).

<p>Blocks of each ancestry (Amerindian, Caucasian, Caucasian shared with other populations, African and Asian) were defined as those found in original populations with H.F. >1,0%, and not found in other native human groups in frequencies higher than 1,0%. We consider <i>t</i> value must be ≥2.0 to denote statistically significant association and thus validate Δ′ (shaded values).^† Similar to DQB1*05∶02 with a silent mutation at codon 133 cgg>cga.</p

Measures of genetic diversity at the allele level for HLA system in a Mexican admixed population.

<p>O.H.: Observed heterozygosity. E.H.: Expected Heterozygosity. <i>p</i> values <0.05 are considered statistically significative and thus reflect differences between O.H. and E.H. PIC: Polymorphism Information Contents. PD: Power of Discrimination.</p

Extension of HLA Conserved Extended Haplotypes to <i>HLA-A</i> in 234 Mexican Admixed individuals.

<p>Blocks of each ancestry (Amerindian, Caucasian, Caucasian shared with other populations, African and Asian) were defined as those found in original populations with H.F. >1,0%, and not found in other native human groups in frequencies higher than 1,0%. We consider <i>t</i> value must be ≥2.0 to denote statistically significant association and thus validate Δ′ (shaded values).</p

Frequencies of <i>HLA-C-B</i> blocks in 234 admixed Mexican individuals (468 haplotypes).

<p>Blocks of each ancestry (Amerindian, Caucasian, Caucasian shared with other populations, African, and Asian) were defined as those found in original populations with H.F. >1,0%, and not found in other native human groups in frequencies higher than 1,0%. We consider <i>t</i> value must be ≥2.0 to denote statistically significant association and thus validate Δ′ (shaded values).</p>*<p>Similar to B*35∶01 with a mutation at codon 207 ggc>tgc (Gly>Cys).</p>§<p>Similar to C*03∶04 with a mutation at codon 189 gtg>atg (Val>Met).</p

Allelic frequencies of <i>HLA-A, -B, -C, -DRB1</i>, and <i>-DQB1</i> in 234 Mexicans.

*<p>Similar to B*35∶01 with a mutation at codon 207 ggc>tgc (Gly>Cys).</p>§<p>Similar to C*03∶04 with a mutation at codon 189 gtg>atg (Val>Met).</p>†<p>Similar to DQB1*05∶02 with a silent mutation at codon 133 cgg>cga.</p