Characteristics of the IDBs in relationship to the classification of the access diameter for the interdental space.

<p>Characteristics of the IDBs in relationship to the classification of the access diameter for the interdental space.</p

Distribution (mean ± sd) of the number of interproximal sites according to the diameter of the interproximal brush in 99 adults.

<p>Distribution (mean ± sd) of the number of interproximal sites according to the diameter of the interproximal brush in 99 adults.</p

Distribution of interproximal sites (n = 2408^a) from 99 adults according to adult’s variables.

<p>Distribution of interproximal sites (n = 2408<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0155467#t004fn001" target="_blank">^a</a>) from 99 adults according to adult’s variables.</p

IAP CURAPROX probe.

<p>IAP CURAPROX probe.</p

IDB and bleeding in sites with spaces (n = 2408) in 99 adults.

<p>IDB and bleeding in sites with spaces (n = 2408) in 99 adults.</p

Distribution of characteristics in interproximal sites (30/subject), denoted in bars, corresponding to 99 adults*.

<p>(A) Distribution of interproximal sites (99 x 30 = 2970 sites) from 99 adults according to the type of tooth. (B) Distribution of interproximal diameter access in 2408 sites with spaces. (C) Distribution of bleeding after interproximal brush in 2408 sites. * Note that the teeth are numbered.</p

Univariate and multivariate associations^a between studied variables and interproximal bleeding after IDB (n = 2408 sites).

<p>Univariate and multivariate associations<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0155467#t005fn001" target="_blank">^a</a> between studied variables and interproximal bleeding after IDB (n = 2408 sites).</p

Spatial learning and reference memory of the 5-HTR₄ knock-out mice (experiment 2).

<p>Effect of scopolamine injection (0.8 mg/kg, i.p., 20 min) on performance. Left-hand side (A): mean ± s.e. of path length (cm) over days (1–4) in wild type (WT) and 5-HTR₄ knock-out (KO) mice. Right-hand side (B): Probe trials (60 s) on days 4 and 5. Top: Mean ± s.e. path length in the whole pool (swim speed) of the WT and KO mice. Bottom: Mean ± s.e. path length in the target platform zone/sum of path lengths in the four equivalent zones (target PF/totPFs) in WT and KO mice. Horizontal lines represent chance level. A significant treatment effect is noted (* p = 0.05, ** p = 0.02).</p

Spatial learning and reference memory of the 5-HTR₄ knock-out mice (experiment 1).

<p>Left-hand side (A): Performance over days (2–14) for the acquisition (days 2–10) and the reversal (days 11–14) of spatial memory testing in the Morris water maze for wild-type (WT) and 5-HTR₄ knock-out (KO) mice. The score on each day represents the mean ± s.e. of path length (cm). Right-hand side (B): Probe trials (60 s) on days 5, 10, 14, 15, and 20. Mean ± s.e. path length in the target platform zone/sum of path lengths in the four equivalent zones (target PF/totPFs) in WT and KO mice. Horizontal lines represent chance level.</p

Reduced enzymatic activity of ChAT in the absence of 5-HTR₄.

<p>Values are means ± s.e.m. of ChAT activity expressed in <i>p</i>mol ACh/min/µg protein for 7–8 WT and 6–7 KO mice in baseline conditions and 3–4 WT and 3–4 KO mice following the session of behavioral tests. A significant difference between genotypes or conditions is marked (* p<0.05, ** p<0.01 and §§ p<0.01, §§§ p<0.001, respectively). The genotype x condition interaction is significant (# p<0.05).</p