Corporal punishment and youth externalizing behavior in Santiago, Chile

OBJECTIVES: Corporal punishment is still widely practiced around the globe, despite the large body of child development research that substantiates its short- and long-term consequences. Within this context, this paper examined the relationship between parental use of corporal punishment and youth externalizing behavior with a Chilean sample to add to the growing empirical evidence concerning the potential relationship between increased corporal punishment and undesirable youth outcomes across cultures. METHODS: Analysis was based on 919 adolescents in Santiago, Chile. Descriptive and multivariate analyses were conducted to examine the extent to which parents' use of corporal punishment and positive family measures were associated with youth externalizing behavior. Furthermore, the associations between self-reported externalizing behavior and infrequent, as well as frequent, use of corporal punishment were investigated to understand how varying levels of parental use of corporal punishment were differently related to youth outcomes. RESULTS: Both mothers' and fathers' use of corporal punishment were associated with greater youth externalizing behavior. Additionally, increases in positive parenting practices, such as parental warmth and family involvement, were met with decreases in youth externalizing behavior when controlling for youth demographics, family socioeconomic status, and parents' use of corporal punishment. Finally, both infrequent and frequent use of corporal punishment were positively associated with higher youth problem behaviors, though frequent corporal punishment had a stronger relationship with externalizing behavior than did infrequent corporal punishment. CONCLUSIONS: Parental use of corporal punishment, even on an occasional basis, is associated with greater externalizing behavior for youth while a warm and involving family environment may protect youth from serious problem behaviors. Therefore, findings of this study add to the growing evidence concerning the negative consequences of corporal punishment for youth outcomes.R01 HD033487 - NICHD NIH HHS; R01 DA021181 - NIDA NIH HH

Relationship between discordance in parental monitoring and behavioral problems among Chilean adolescents

This study investigated the role of discrepancies between parent and youth reports of perceived parental monitoring in adolescent problem behaviors with a Chilean sample (N= 850). Higher levels of discordance concerning parental monitoring predicted greater levels of maladaptive youth behaviors. A positive association between parent-youth discordance and externalizing problems indicated that large adult-youth disagreement in parental monitoring may impose a great risk, despite protective efforts of parental monitoring. Although the direct relationship between parental monitoring and youth internalizing behaviors was not significant, parent-youth incongruence in monitoring was associated with greater levels of internalizing behaviors. Therefore, differing assessments of parental behaviors, as an indicator of less optimal family functioning, may provide important information about youth maladjustment and may potentially provide a beginning point for family-focused intervention.R01 DA021181 - NIDA NIH HHS; R01 DA021181-05 - NIDA NIH HHS; R01 HD033487 - NICHD NIH HH

Comparison of Vaginal Misoprostol and Oral Misoprostol for promoting Cervical Ripening and Inducing labor

Background: Labor induction is the stimulation of the uterus to contract before labor begins to have a vaginal birth through the use of medications. Labor induction in the later stages of pregnancy is used to prevent complications when the mother or baby is at risk. Medications such as misoprostol (Cytotec) are used in inductions for cervical ripening to allow smoother dilation. Ripening the cervix is a method used to help soften and thin out the cervix to facilitate childbirth. The benefit of using misoprostol is that it can be administered several routes including oral, vaginal, sublingual and buccal. Induction of labor is a life-saving intervention that can reduce adverse outcomes. Purpose: This systematic literature review aims to determine the most effective route of administration of misoprostol to successfully induce labor in term pregnant women. Methods: The PRISMA flow diagram was followed to obtain results. A literature search was conducted using resources including PubMed and EBSCO Information Services as well as specific internet searches. Filters were applied to limit retrievals to only randomized control trials, controlled clinical trials, and experimental studies. Other inclusion criteria were the administration of oral misoprostol, vaginal misoprostol, buccal misoprostol, or sublingual misoprostol, a non-scarred uterus, gestational weeks ≥ 37, English language, and healthcare data from the year 2017 to present. The Johns Hopkins Evidence-Based Practice Model was used for an appraisal process to select twenty articles to be used in our review. Preliminary results suggest the vaginal route is more effective than oral misoprostol in performing successful labor inductions in the shortest amount of time. Results: Final results will be presented at the symposiu

A conserved circadian function for the Neurofibromatosis 1 gene

Summary: Loss of the Neurofibromatosis 1 (Nf1) protein, neurofibromin, in Drosophila disrupts circadian rhythms of locomotor activity without impairing central clock function, suggesting effects downstream of the clock. However, the relevant cellular mechanisms are not known. Leveraging the discovery of output circuits for locomotor rhythms, we dissected cellular actions of neurofibromin in recently identified substrates. Herein, we show that neurofibromin affects the levels and cycling of calcium in multiple circadian peptidergic neurons. A prominent site of action is the pars intercerebralis (PI), the fly equivalent of the hypothalamus, with cell-autonomous effects of Nf1 in PI cells that secrete DH44. Nf1 interacts genetically with peptide signaling to affect circadian behavior. We extended these studies to mammals to demonstrate that mouse astrocytes exhibit a 24-hr rhythm of calcium levels, which is also attenuated by lack of neurofibromin. These findings establish a conserved role for neurofibromin in intracellular signaling rhythms within the nervous system. : Bai et al. show that the gene mutated in the disease Neurofibromatosis 1 is required for maintaining levels or cycling of calcium in circadian neurons in Drosophila and in mammalian cells. These effects likely account for effects of Nf1 on circadian behavior in Drosophila and may be relevant in explaining sleep phenotypes in patients. Keywords: circadian rhythms, neurofibromatosis 1, Drosophila, peptide signaling, cycling of calcium, mouse astrocyte

Spectroscopic confirmation of an ultra-faint galaxy at the epoch of reionization

Within one billion years of the Big Bang, intergalactic hydrogen was ionized by sources emitting ultraviolet and higher energy photons. This was the final phenomenon to globally affect all the baryons (visible matter) in the Universe. It is referred to as cosmic reionization and is an integral component of cosmology. It is broadly expected that intrinsically faint galaxies were the primary ionizing sources due to their abundance in this epoch. However, at the highest redshifts ($z>7.5$; lookback time 13.1 Gyr), all galaxies with spectroscopic confirmations to date are intrinsically bright and, therefore, not necessarily representative of the general population. Here, we report the unequivocal spectroscopic detection of a low luminosity galaxy at $z>7.5$. We detected the Lyman-$\alpha$ emission line at $\sim 10504$ {\AA} in two separate observations with MOSFIRE on the Keck I Telescope and independently with the Hubble Space Telescope's slit-less grism spectrograph, implying a source redshift of $z = 7.640 \pm 0.001$. The galaxy is gravitationally magnified by the massive galaxy cluster MACS J1423.8+2404 ($z = 0.545$), with an estimated intrinsic luminosity of $M_{AB} = -19.6 \pm 0.2$ mag and a stellar mass of $M_{\star} = 3.0^{+1.5}_{-0.8} \times 10^8$ solar masses. Both are an order of magnitude lower than the four other Lyman-$\alpha$ emitters currently known at $z > 7.5$, making it probably the most distant representative source of reionization found to date

Improving K-means clustering with enhanced Firefly Algorithms

In this research, we propose two variants of the Firefly Algorithm (FA), namely inward intensified exploration FA (IIEFA) and compound intensified exploration FA (CIEFA), for undertaking the obstinate problems of initialization sensitivity and local optima traps of the K-means clustering model. To enhance the capability of both exploitation and exploration, matrix-based search parameters and dispersing mechanisms are incorporated into the two proposed FA models. We first replace the attractiveness coefficient with a randomized control matrix in the IIEFA model to release the FA from the constraints of biological law, as the exploitation capability in the neighbourhood is elevated from a one-dimensional to multi-dimensional search mechanism with enhanced diversity in search scopes, scales, and directions. Besides that, we employ a dispersing mechanism in the second CIEFA model to dispatch fireflies with high similarities to new positions out of the close neighbourhood to perform global exploration. This dispersing mechanism ensures sufficient variance between fireflies in comparison to increase search efficiency. The ALL-IDB2 database, a skin lesion data set, and a total of 15 UCI data sets are employed to evaluate efficiency of the proposed FA models on clustering tasks. The minimum Redundancy Maximum Relevance (mRMR)-based feature selection method is also adopted to reduce feature dimensionality. The empirical results indicate that the proposed FA models demonstrate statistically significant superiority in both distance and performance measures for clustering tasks in comparison with conventional K-means clustering, five classical search methods, and five advanced FA variants

Natural Oculomotor Performance in Looking and Tapping Tasks

A unique apparatus recorded eye and head movements of subjects as they tapped or only looked at sequences of 2, 4 or 6 nearby, 3-D targets. Each sequence was repeated 10 times to allow an opportunity for learning. A stereotypical pattern of movements was established after 2-3 repetitions. Subjects almost always looked at each target just before tapping it. Looking-only was more difficult than tapping in that it took more time and, unlike tapping, usually did not benefit from practice. The number of targets in a sequence affected timeA^get in both tasks. Sequence length and practice effects show that memory was involved. The persistent strategy of looking before tapping and the subjects' inability to tap a well-leamed patten with eyes closed, show that visual cues were also important We conclude that motor plarming occurred first at the level of the task and then at the level of specific motor programs. The relative difficulty of the less natural, looking-only task, in which the eyes worked without a meaningful cognitive or motor purpose, suggests that efficient eye movement programming requires a natural task of the kind eye movements evolved to serve