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Pd-NHC Catalytic System for the Efficient Atom-Economic Synthesis of Vinyl Sulfides from Tertiary, Secondary, or Primary Thiols
Vinyl sulfides represent an important
class of compounds in organic
chemistry and materials science. Atom-economic addition of thiols
to the triple bond of alkynes provides an excellent opportunity for
environmentally friendly processes. We have found that well-known
and readily available Pd-NHC complex (IMes)ÂPdÂ(acac)Cl is an efficient
catalyst for alkyne hydrothiolation. The reported technique provides
a general one-pot approach for the selective preparation of Markovnikov-type
vinyl sulfides starting from tertiary, secondary, or primary aliphatic
thiols, as well as benzylic and aromatic thiols. In all the studied
cases, the products were formed in excellent selectivity and good
yields