11 research outputs found
Sociodemographic and clinical characteristics.
a<p>Data are presented as mean Β± SD. Group differences were analyzed using chi-square tests (categorical data) and <i>t</i>-tests (continuous data). CAPS, Clinician Administered PTSD Scale; HAM-D, Hamilton Depression Rating Scale; SOMS-7, Screening for Somatoform Symptoms-7.</p
Glucocorticoid receptor isoform expression.
<p>Expression levels of glucocorticoid receptor (GR) Ξ± and Ξ² isoforms as well as GRΞ±/GRΞ² ratio in the peripheral blood of non-PTSD subjects (<i>n</i>β=β35) and PTSD patients (<i>n</i>β=β42) measured by real-time quantitative PCR. Means and SEM are shown. ** <i>p</i>β=β0.01.</p
Relationship between trauma load and GRΞ± isoform expression.
<p>(A) Number of different traumatic event types, (B) PTSD symptom severity, and (C) GRΞ± mRNA expression levels in non-PTSD subjects with no or few traumatic experiences (0β3 traumatic event types; <i>low trauma-exposed non-PTSD</i>; <i>n</i>β=β20), in non-PTSD subjects with substantial exposure to traumatic stressors (4β8 traumatic event types; <i>high trauma-exposed non-PTSD</i>; <i>n</i>β=β15), and in PTSD patients (<i>n</i>β=β42). Means and SEM are shown. * <i>p</i><0.05, ** <i>p</i><0.01, *** <i>p</i><0.001.</p
Blood cell parameters and plasma cortisol concentration.
<p>Data are presented as mean Β± SD.</p
Effect of comorbid depression or the use of antidepressants on plasma EC/NAE concentrations.
<p>Effect of comorbid depression or the use of antidepressants on plasma EC/NAE concentrations.</p
Correlation between CAPS scores and PEA plasma levels in individuals after trauma exposure (nβ=β19).
<p>Panel A: CAPS sum score (rβ=β0.54, pβ=β0.02); Panel B: CAPS β intrusion subscore (rβ=β0.65, p<0.01); Panel C: CAPS β avoidance subscore (rβ=β0.21, pβ=β0.40); Panel D: CAPS - hyperarousal subscore (rβ=β0.29, pβ=β0.23). Solid line indicates regression line and dotted lines 95% confidence intervals.*marks significant correlations.</p
Relationship between OLDA plasma concentrations and CAPS scores.
<p>Panel A: CAPS sum score (rβ=ββ0.68, p<0.01, nβ=β19); Panel B: CAPS β intrusion subscore (rβ=ββ0.65, p<0.01); Panel C: CAPS β avoidance subscore (rβ=ββ0.59, p<0.01); Panel D: CAPS β hyperarousal subscore (rβ=ββ0.66, p<0.01). Solid line indicates regression line and dotted lines 95% confidence intervals.</p
Comorbidities (except depression) or medication use (except antidepressants) and plasma EC/NAE concentrations in individuals after trauma exposure.
a<p>Comorbidities were rheumatic disease (nβ=β1), hepatitis B (nβ=β1) and chronic gastritis (nβ=β2).</p>b<p>Medications were contraceptives (nβ=β2), mood stabilizers (nβ=β1) and antacids (nβ=β2).</p
Correlation between the number of CAPS traumatic event types and OLDA plasma concentrations (rβ=ββ0.50, pβ=β0.03, nβ=β19).
<p>The solid line represents the regression line and dotted lines 95% confidence intervals.</p
Demographic and clinical data of the study groups.
a<p>Data are meanΒ±SD; (y)β=β years; (f)β=β female; (m)β=β male.</p>b<p>Trauma-exposed patients received amitriptylin (nβ=β2), PTSD patients mirtazapin (nβ=β2) and amitriptylin+mirtazapin (nβ=β1).</p>c<p>These scores were only available for ethnically matched controls recruited by the Trauma Center of University of Konstanz (nβ=β9).</p>d<p>Trauma-exposed individuals without PTSD were of Caucasian origin (nβ=β6) (two from Iran and two from Turkey, one from Bosnia and one from Afghanistan) and 3 were Black-Africans (one from Gambia, one from Eritrea and one from Senegal).</p>e<p>Trauma- exposed individuals with PTSD were Caucasians (nβ=β8) (two from Turkey, two from Iran, one from Afghanistan, one from Syria, one from Kosovo and one from Bosnia) and two were Black-Africans (one from Nigeria and one from Togo).</p>f<p>Controls were Caucasians (twenty were Germans, one each were from Turkey, Armenia, Israel, two from Romania and two were Russians) and 2 were from Africa (Eritrea and Sudan).</p>*<p>Significantly higher values compared to trauma-exposed individuals <i>without</i> PTSD and to healthy controls.</p>#<p>Significantly higher values compared to healthy controls.</p